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Journal of Clinical Endocrinology & Metabolism, Vol 40, 256-259, Copyright © 1975 by Endocrine Society

ARTICLES

Inhibition of L-dopa-induced growth hormone stimulation by pyridoxine and chlorpromazine

RB Mims, CL Scott, O Modebe and JE Bethune

One gram of L-dopa was administered orally to 12 male control subjects and induced an increase of growth hormone (GH) secretion. The L-dopa- induced GH response was inhibited by an intravenous infusion of pyridoxine, but pyridoxine did not inhibit the GH response to hypoglycemia. Chlorpromazine also inhibited L-dopa-induced GH stimulation. Glucose concentrations were unaffected by L-dopa, chlorpromazine, and pyridoxine administration in these subjects. The mechanism of the suppressed L-dopa-induced GH response by pyridoxine appears to be mediated by peripheral accleration of the conversion of L- dopa to dopamine, while that of chlorpromazine appears to be mediated through hypothalamic centers. Pyridoxine and chlorpromazine should be added to the list of other factors affecting the response to L-dopa- induced GH stimulation


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S.-G. Ren and S. Melmed
Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion
Endocrinology, August 1, 2006; 147(8): 3936 - 3942.
[Abstract] [Full Text] [PDF]


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