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Journal of Clinical Endocrinology & Metabolism, Vol 40, 509-511, Copyright © 1975 by Endocrine Society

ARTICLES

Fasting blunts the TSH response to synthetic thyrotropin-releasing hormone (TRH)

AI Vinik, WJ Kalk, H McLaren, S Hendricks and BL Pimstone

Thyrotropin (TSH) responses to intravenous thyrotropin-releasing hormone (TRH) were studied in 9 men after 12 and 36-h fasts separated by more than a week and performed in random order. The TSH, basally and in response to TRH, was significantly lower after the 36-h fast compared to that after 12 h. The mechanism for this effect is not clear, but may be related to the altered hormonal or fuel status associated with prolonged fasting.


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