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Journal of Clinical Endocrinology & Metabolism, Vol 40, 742-745, Copyright © 1975 by Endocrine Society

ARTICLES

A radioimmunoassay for the measurement of pyroglutamyl-histidyl- proline, a proposed thyrotropin releasing hormone metabolite

TJ Visser, W Klootwijk, R Docter and G Hennemann

A highly specific radioimmunoassay for the measurement of pGlu-His-Pro- OH (TRH-OH), a compound proposed to be a metabolite of pGlu-His-Pro-NH2 (TRH) has been developed. Using this assay experiments have been performed to study the inactivation of TRH and TRH-OH by serum. The results show that TRH-OH is inactivated in a fashion resembling the inactivation of TRH as has been described by others. Support for the deamidation mechanism as the main pathway for TRH degradation could not be achieved.




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Copyright © 1975 by The Endocrine Society