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Journal of Clinical Endocrinology & Metabolism, Vol 40, 783-789, Copyright © 1975 by Endocrine Society

ARTICLES

Integration of pulsatile gonadotropin secretion by timed urinary measurements: an accurate and sensitive 3-hour test

HE Kulin, PM Bell, RJ Santen and AJ Ferber

The integration of pulsatile gonadotropin secretion by the radioimmunoassay of an acetone precipitation from a short-term urine sample was evaluated. FSH and LH excretion over a 3-h period was compared to the mean level of 10 blood samples obtained every 20 min for a similar time period from 71 patients. A highly significant correlation existed between blood and urine results. In addition, the gonadotropin levels obtained from a 3-h sample correlated well with the 24 h excretion of FSH and LH from the same individual. A 3-h urine collection can provide a simple, sensititve, and accurate means of assessing circulating FSH and LH levels.


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