Journal of Clinical Endocrinology & Metabolism, Vol 40, 850-855, Copyright © 1975 by Endocrine Society

ARTICLES

24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate

RS Rosenfeld, BJ Rosenberg, DK Fukushima and L Hellman

Dehydroisoandrosterone (DHA) and cortisol were measured by radioimmunoassay and protein binding techniques respectively in plasma from blood taken at 20-min intervals over 24-h periods in 3 normal men, 2 women with Stein-Leventhal syndrome and a man with a benign adrenocortical adenoma. In all subjects but the latter, DHA and cortisol were episodic and synchronous throughout the entire day; in this patient, continuous secretion of cortisol by the tumor apparently abolished stimulation of the contralateral adrenal, and DHA production was negligible. Dehydroisoandrosterone sulfate analysis in plasma displayed a pattern which, probably because of its origin both by secretion and sulfation and its long half-life showed less synchronicity with DHA and cortisol and less fluctuation than did the free hormones.

This article has been cited by other articles:

				N. Friedrich, H. Volzke, D. Rosskopf, A. Steveling, A. Krebs, M. Nauck, and H. Wallaschofski Reference Ranges for Serum Dehydroepiandrosterone Sulfate and Testosterone in Adult Men J Androl, November 1, 2008; 29(6): 610 - 617. [Abstract] [Full Text] [PDF]

				L. Marinelli, E. Trevisi, L. Da Dalt, M. Merlo, G. Bertoni, and G. Gabai Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation J. Endocrinol., September 1, 2007; 194(3): 627 - 635. [Abstract] [Full Text] [PDF]

				R. Muniyappa, K. A. Wong, H. L. Baldwin, J. D. Sorkin, M. L. Johnson, S. Bhasin, S. M. Harman, and M. R. Blackman Dehydroepiandrosterone Secretion in Healthy Older Men and Women: Effects of Testosterone and Growth Hormone Administration in Older Men J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4445 - 4452. [Abstract] [Full Text] [PDF]

				H. Kobayashi, F. Kambe, T. Imai, Y. Hibi, T. Kikumori, S. Ohmori, A. Nakao, and H. Seo Differential expression of cyclin-dependent kinase inhibitors, p27Kip1 and p57Kip2, by corticotropin in rat adrenal cortex. J. Endocrinol., June 1, 2006; 189(3): 671 - 679. [Abstract] [Full Text] [PDF]

				H. S. Willenberg, M. Bahlo, W. A. Scherbaum, F. de Zegher, D. B. Dunger, L. Ibanez, and R. L. Rosenfield Hirsutism. N. Engl. J. Med., April 6, 2006; 354(14): 1533 - 1535. [Full Text] [PDF]

				M. J. Reed, A. Purohit, L. W. L. Woo, S. P. Newman, and B. V. L. Potter Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocr. Rev., April 1, 2005; 26(2): 171 - 202. [Abstract] [Full Text] [PDF]

				I. M. GOODYER, R. J. PARK, C. M. NETHERTON, and J. HERBERT Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology The British Journal of Psychiatry, September 1, 2001; 179(3): 243 - 249. [Abstract] [Full Text] [PDF]

				H. A. Feldman, C. B. Johannes, A. B. Araujo, B. A. Mohr, C. Longcope, and J. B. McKinlay Low Dehydroepiandrosterone and Ischemic Heart Disease in Middle-aged Men: Prospective Results from the Massachusetts Male Aging Study Am. J. Epidemiol., January 1, 2001; 153(1): 79 - 89. [Abstract] [Full Text] [PDF]

				A. J. Alberg, G. B. Gordon, S. C. Hoffman, G. W. Comstock, and K. J. Helzlsouer Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate and the Subsequent Risk of Developing Colon Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2000; 9(5): 517 - 521. [Abstract] [Full Text]

				S. B. Solerte, M. Fioravanti, G. Vignati, A. Giustina, L. Cravello, and E. Ferrari Dehydroepiandrosterone Sulfate Enhances Natural Killer Cell Cytotoxicity in Humans Via Locally Generated Immunoreactive Insulin-Like Growth Factor I J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3260 - 3267. [Abstract] [Full Text]

				G. Lac, P. Marquet, A. P. Chassain, and F. X. Galen Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones J Appl Physiol, July 1, 1999; 87(1): 183 - 188. [Abstract] [Full Text] [PDF]

				C. Ankarberg and E. Norjavaara Diurnal Rhythm of Testosterone Secretion before and throughout Puberty in Healthy Girls: Correlation with 17{beta}-Estradiol and Dehydroepiandrosterone Sulfate J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 975 - 984. [Abstract] [Full Text]

				E. S. Knochenhauer, T. J. Key, M. Kahsar-Miller, W. Waggoner, L. R. Boots, and R. Azziz Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3078 - 3082. [Abstract] [Full Text]