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Journal of Clinical Endocrinology & Metabolism, Vol 47, 1164-1167, Copyright © 1978 by Endocrine Society

ARTICLES

Studies of the human testis. XI. Leydig cell clusters and levels of intratesticular testosterone and 20 alpha-dihydroprogesterone

M Hosaka, H Oshima, H Nankin and P Troen

Testosterone concentration in testes of 23 men, ages 51 to 90, was determined as 490 +/- 172 ng/g tissue (M +/- S.D.) and 20 alpha- dihydroprogesterone concentration as 10.0 +/- 2.3 ng/g tissue (M +/- S.D.) in 18 men of the same patient group. Leydig cells were estimated by the number of Leydig cell clusters per tubule. There was a high correlation (r = 0.88, p less than .001) of the Leydig cell index with intratesticular testosterone. It is proposed that the Leydig cell cluster index provides a direct index of steroid biosynthetic activity in the human testis as reflected in intratesticular testosterone levels. Although there was no significant correlation of 20 alpha- dihydroprogesterone levels in the testis with either the Leydig cell index or intratesticular testosterone, the high level of 20 alpha- dihydroprogesterone compared to peripheral levels suggests its production by the testis.




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Copyright © 1978 by The Endocrine Society