help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wisgerhof, M.
Right arrow Articles by Brown, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wisgerhof, M.
Right arrow Articles by Brown, R. D.

Journal of Clinical Endocrinology & Metabolism, Vol 47, 938-943, Copyright © 1978 by Endocrine Society

ARTICLES

Increased adrenal sensitivity to angiotensin II in idiopathic hyperaldosteronism

M Wisgerhof, PC Carpenter and RD Brown

Plasma aldosterone increases briskly during upright posture in patients with idiopathic hyperaldosteronism, despite only small increases in PRA and presumably small increases in angiotensin II. To examine the postulate that small increments in angiotensin II mediate these brisk increases in aldosterone, we infused graded doses of angiotensin II into normal subjects and patients with idiopathic hyperaldosteronism and compared the changes in levels of plasma aldosterone in the two groups. Supplemental sodium and dexamethasone were given before the infusion to minimize the influence of endogenous angiotensin II and ACTH. In response to the infusion of angiotensin II, increases in the levels of plasma aldosterone of patients with idiopathic hyperaldosteronism were significantly greater than those of normal subjects. In addition, levels of plasma aldosterone increased at a lower rate of infusion of angiotensin II in patients than in normal subjects. It is concluded that patients with idiopathic hyperaldosteronism have increased adrenal sensitivity to angiotensin II. This increased sensitivity may explain the brisk increases in aldosterone that occur during upright posture in these patients.


This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
A. Karagiannis, K. Tziomalos, A. I Kakafika, V. G Athyros, F. Harsoulis, and D. P Mikhailidis
Medical treatment as an alternative to adrenalectomy in patients with aldosterone-producing adenomas
Endocr. Relat. Cancer, September 1, 2008; 15(3): 693 - 700.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Davies, C. Hu, N. A. Guagliardo, N. Sen, X. Chen, E. M. Talley, R. M. Carey, D. A. Bayliss, and P. Q. Barrett
TASK channel deletion in mice causes primary hyperaldosteronism
PNAS, February 12, 2008; 105(6): 2203 - 2208.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. Mulatero, F. Rabbia, A. Milan, C. Paglieri, F. Morello, L. Chiandussi, and F. Veglio
Drug Effects on Aldosterone/Plasma Renin Activity Ratio in Primary Aldosteronism
Hypertension, December 1, 2002; 40(6): 897 - 902.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. Carroll and T. Goodfriend
Androgen modulation of adrenal angiotensin receptors
Science, June 1, 1984; 224(4652): 1009 - 1011.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1978 by The Endocrine Society