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Journal of Clinical Endocrinology & Metabolism, Vol 47, 1387-1389, Copyright © 1978 by Endocrine Society

ARTICLES

Insulin receptors during the menstrual cycle in normal women

R De Pirro, A Fusco, A Bertoli, AV Greco and R Lauro

Specific binding of 125I-insulin to circulating monocytes from eight normal menstruating women, four postmenopausal women and four men were studied four times during a 28-day period (one sample at 7-day intervals). Data indicate the presence of a higher specific cell binding fraction in the follicular phase compared to the luteal phase due to changes in insulin receptor concentration. No changes were observed in men or postmenopausal women during the same period of time suggesting that sex hormones should be included among the factors influencing insulin receptors.


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