help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nachtigall, L. B.
Right arrow Articles by Crowley, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nachtigall, L. B.
Right arrow Articles by Crowley, W. F., Jr

Journal of Clinical Endocrinology & Metabolism, Vol 81, 3520-3525, Copyright © 1996 by Endocrine Society

ARTICLES

Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment--a clinical research center study

LB Nachtigall, PA Boepple, SB Seminara, RH Khoury, PM Sluss, AE Lecain and WF Crowley Jr
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA.

To evaluate the physiology of inhibin B in the human male, we measured serum concentrations in normal adult men and men with isolated GnRH deficiency before and during long-term replacement with pulsatile GnRH. At baseline, inhibin B levels in the GnRH-deficient men (n = 31) were significantly lower than normal controls (85 +/- 10 pg/mL vs. 239 +/- 14 pg/mL; P < .01) and correlated positively with pretreatment testicular volume (r = .80, P = .001) and a history of spontaneous puberty, suggesting additional maturational influences on the both testicular volume and inhibin B secretion. Pulsatile GnRH administration was associated with significant increases in inhibin B, with levels averaging 108 +/- 7 pg/mL when serum LH, FSH, and T concentrations had reached the normal adult male range (n = 22; P = .02 vs. baseline). Continued GnRH administration for at least an additional year was not associated with further increases in inhibin B concentrations. Throughout the course of long-term pulsatile GnRH replacement, serum FSH levels were negatively correlated with inhibin B concentrations (e.g. r = -.71, P < 0.01; n = 14 treated 12 months after normalization of T). Although inhibin B concentrations did not correlated with sperm density during therapy, rates of fertility were higher in patients with higher baseline levels (inhibin B > or = 60 pg/mL). Increases in serum concentrations of inhibin B occurring during GnRH replacement demonstrate the gonadotropin regulation of gonadal inhibin B secretion. However, the variation in baseline inhibin B levels before GnRH administration suggests an additional gonadotropin- independent level of modulation. The negative correlation between FSH and inhibin B secretion in GnRH-deficient men receiving long-term GnRH replacement is consistent with a putative role of inhibin B in the negative feedback regulation of FSH, although direct confirmation of this role requires further investigation.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
P. A. Boepple, F. J. Hayes, A. A. Dwyer, T. Raivio, H. Lee, W. F. Crowley Jr, and N. Pitteloud
Relative Roles of Inhibin B and Sex Steroids in the Negative Feedback Regulation of Follicle-Stimulating Hormone in Men across the Full Spectrum of Seminiferous Epithelium Function
J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1809 - 1814.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Lofrano-Porto, G. B. Barra, L. A. Giacomini, P. P. Nascimento, A. C. Latronico, L. A. Casulari, and F. d. A. da Rocha Neves
Luteinizing Hormone Beta Mutation and Hypogonadism in Men and Women
N. Engl. J. Med., August 30, 2007; 357(9): 897 - 904.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. M. Grumbach
A Window of Opportunity: The Diagnosis of Gonadotropin Deficiency in the Male Infant
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 3122 - 3127.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Young, P. Chanson, S. Salenave, M. Noel, S. Brailly, M. O'Flaherty, G. Schaison, and R. Rey
Testicular Anti-Mullerian Hormone Secretion Is Stimulated by Recombinant Human FSH in Patients with Congenital Hypogonadotropic Hypogonadism
J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 724 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. L. Matthiesson, D. M. Robertson, H. G. Burger, and R. I. McLachlan
Response of serum inhibin B and pro-{alpha}C levels to gonadotrophic stimulation in normal men before and after steroidal contraceptive treatment
Hum. Reprod., April 1, 2003; 18(4): 734 - 743.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
W. Jin, C. B. Herath, M. Yoshida, K. Y. Arai, E. Saita, S. Zhanquan, L. Ren, G. Watanabe, N. P. Groome, and K. Taya
Inhibin B Regulating Follicle-Stimulating Hormone Secretion During Testicular Recrudescence in the Male Golden Hamster
J Androl, November 1, 2002; 23(6): 845 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. Welt, Y. Sidis, H. Keutmann, and A. Schneyer
Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium
Experimental Biology and Medicine, October 1, 2002; 227(9): 724 - 752.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Pitteloud, F. J. Hayes, A. Dwyer, P. A. Boepple, H. Lee, and W. F. Crowley Jr.
Predictors of Outcome of Long-Term GnRH Therapy in Men with Idiopathic Hypogonadotropic Hypogonadism
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4128 - 4136.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. M. Kuhn, H. Lefebvre, C. Duparc, A. Pellerin, J. P. Luton, and G. Strauch
Cosecretion of Estrogen and Inhibin B by a Feminizing Adrenocortical Adenoma: Impact on Gonadotropin Secretion
J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2367 - 2375.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. A. Quigley
The Postnatal Gonadotropin and Sex Steroid Surge--Insights from the Androgen Insensitivity Syndrome
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 24 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Pitteloud, F. J. Hayes, P. A. Boepple, S. DeCruz, S. B. Seminara, D. T. MacLaughlin, and W. F. Crowley Jr.
The Role of Prior Pubertal Development, Biochemical Markers of Testicular Maturation, and Genetics in Elucidating the Phenotypic Heterogeneity of Idiopathic Hypogonadotropic Hypogonadism
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 152 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. M. Plant and G. R. Marshall
The Functional Significance of FSH in Spermatogenesis and the Control of Its Secretion in Male Primates
Endocr. Rev., December 1, 2001; 22(6): 764 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. J. Hayes, N. Pitteloud, S. DeCruz, W. F. Crowley Jr., and P. A. Boepple
Importance of Inhibin B in the Regulation of FSH Secretion in the Human Male
J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5541 - 5546.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. A. Lee, M. T. Coughlin, and M. F. Bellinger
Inhibin B: Comparison with Indexes of Fertility among Formerly Cryptorchid and Control Men
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2576 - 2584.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A.J. Tilbrook and I.J. Clarke
Negative Feedback Regulation of the Secretion and Actions of Gonadotropin-Releasing Hormone in Males
Biol Reprod, March 1, 2001; 64(3): 735 - 742.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. J. Hayes, S. DeCruz, S. B. Seminara, P. A. Boepple, and W. F. Crowley Jr.
Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Absence of a Negative Feedback Effect of Testosterone on Follicle-Stimulating Hormone Secretion
J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 53 - 58.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
R. Anniballo, F. Ubaldi, L. Cobellis, M. Sorrentino, L. Rienzi, E. Greco, and J. Tesarik
Criteria predicting the absence of spermatozoa in the Sertoli cell-only syndrome can be used to improve success rates of sperm retrieval
Hum. Reprod., November 1, 2000; 15(11): 2269 - 2277.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. J. Hayes, S. B. Seminara, S. DeCruz, P. A. Boepple, and W. F. Crowley Jr.
Aromatase Inhibition in the Human Male Reveals a Hypothalamic Site of Estrogen Feedback
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3027 - 3035.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Young, B. Couzinet, P. Chanson, S. Brailly, E. Loumaye, and G. Schaison
Effects of Human Recombinant Luteinizing Hormone and Follicle-Stimulating Hormone in Patients with Acquired Hypogonadotropic Hypogonadism: Study of Sertoli and Leydig Cell Secretions and Interactions
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3239 - 3244.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
R.M. Sharpe, M. Walker, M.R. Millar, N. Atanassova, K. Morris, C. McKinnell, P.T.K. Saunders, and H.M. Fraser
Effect of Neonatal Gonadotropin-Releasing Hormone Antagonist Administration on Sertoli Cell Number and Testicular Development in the Marmoset: Comparison with the Rat
Biol Reprod, June 1, 2000; 62(6): 1685 - 1693.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. J. Winters and T. M. Plant
Partial Characterization of Circulating Inhibin-B and Pro-{alpha}C During Development in the Male Rhesus Monkey
Endocrinology, December 1, 1999; 140(12): 5497 - 5504.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
N. Atanassova, C. McKinnell, M. Walker, K. J. Turner, J. S. Fisher, M. Morley, M. R. Millar, N. P. Groome, and R. M. Sharpe
Permanent Effects of Neonatal Estrogen Exposure in Rats on Reproductive Hormone Levels, Sertoli Cell Number, and the Efficiency of Spermatogenesis in Adulthood
Endocrinology, November 1, 1999; 140(11): 5364 - 5373.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
C. Foresta, A. Bettella, M. Rossato, G. La Sala, M. De Paoli, and M. Plebani
Inhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone
Hum. Reprod., April 1, 1999; 14(4): 906 - 912.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. Byrd, M. J. Bennett, B. R. Carr, Y. Dong, F. Wians, and W. Rainey
Regulation of Biologically Active Dimeric Inhibin A and B From Infancy to Adulthood in the Male
J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2849 - 2854.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. J. Hayes, J. E. Hall, P. A. Boepple, and W. F. Crowley Jr.
Differential Control of Gonadotropin Secretion in the Human: Endocrine Role of Inhibin
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 1835 - 1841.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A.-M. Andersson, J. Toppari, A.-M. Haavisto, J. H. Petersen, T. Simell, O. Simell, and N. E. Skakkebæk
Longitudinal Reproductive Hormone Profiles in Infants: Peak of Inhibin B Levels in Infant Boys Exceeds Levels in Adult Men
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 675 - 681.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. M. Wallace, N. P. Groome, S. C. Riley, A. C. Parker, and F. C. W. Wu
Effects of Chemotherapy-Induced Testicular Damage on Inhibin, Gonadotropin, and Testosterone Secretion: A Prospective Longitudinal Study
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3111 - 3115.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. M. Plant, V. Padmanabhan, S. Ramaswamy, D. S. McConnell, S. J. Winters, N. Groome, A. R. Midgley Jr., and A. S. McNeilly
Circulating Concentrations of Dimeric Inhibin A and B in the Male Rhesus Monkey (Macaca mulatta)
J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2617 - 2621.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. R. Mann, M. A. Akinbami, K. Wallen, K. G. Gould, N. P. Groome, I. Swanston, A. S. McNeilly, and H. M. Fraser
Inhibin-B in the Male Rhesus Monkey: Impact of Neonatal Gonadotropin-Releasing Hormone Antagonist Treatment and Sexual Development
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1928 - 1933.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
L. B. Nachtigall, P. A. Boepple, F. P. Pralong, and W. F. Crowley
Adult-Onset Idiopathic Hypogonadotropic Hypogonadism -- A Treatable Form of Male Infertility
N. Engl. J. Med., February 6, 1997; 336(6): 410 - 415.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society