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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CALCITONIN, SALMON
*PENTAGASTRIN
Medline Plus Health Information
*Thyroid Cancer
The Journal of Clinical Endocrinology & Metabolism Vol. 82, No. 2 338-341
Copyright © 1997 by The Endocrine Society

Clinical Studies

Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients

Patricia Niccoli, Nelly Wion-Barbot, Philippe Caron, Jean-Francois Henry, Catherine de Micco, Jean-Pierre Saint Andre, Jean-Claude Bigorgne, Elisabeth Modigliani, Bernard Conte-Devolx and and the French Medullary Study Group

Service d’Endocrinologie (P.N., B.C.-D.) and Service de Chirurgie Endocrinienne (J-F.H.) and Laboratoire d’Anatomopathologie (C.dM.), CHU la Timone, and U-38, Faculté de Médecine (P.N.), Marseille; Service d’Endocrinologie (N.W-B., J-C.B.) et Laboratoire d’Anatomopathologie, CHU Angers (J-P.S.A.), Angers; Service d’Endocrinologie, CHU Rangueil (P.C.), Toulouse; and Service d’Endocrinologie, Hopital Avicenne (E.M.), Bobigny, France

Address all correspondence and requests for reprints to: Dr. Patricia Niccoli, Unité 38, Faculté de Médecine, boulevard Jean Moulin, 13385 Marseille Cedex 05, France.

The aim of our study was to assess the ability of routine calcitonin (CT) measurement to improve the preoperative diagnosis of medullary thyroid carcinoma (MTC) in nodular thyroid diseases. We systematically determined basal CT in 1167 patients before thyroid surgery and performed a pentagastrin (Pg) CT stimulation test in 121 of these patients whose basal CT level was normal.

Sixteen MTC (1.37%) were found on histopathological examination of surgical specimens: 14 in the 34 patients (41.1%) with abnormal basal CT levels and 2 in the 1133 patients with normal basal CT levels (0.17%).

An abnormal increase in Pg-stimulated CT was observed in 7 of the 121 patients tested and was related to microscopic MTC in 2 cases.

Among 1167 thyroidectomized patients with nodular thyroid diseases, the prevalence of MTC was 1.37% and reached 41.1% when the basal CT level was abnormal (3% of the patients). CT evaluation detected MTC, whereas other procedures, such as fine needle aspiration cytology, failed, thus allowing early radical surgery.

CT measurement should thus become a routine part of the diagnostic evaluation of nodular thyroid diseases.




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