This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bouvattier, C. Articles by Bougnères, P. F. Search for Related Content PubMed PubMed Citation Articles by Bouvattier, C. Articles by Bougnères, P. F.

Lack of Effect of GnRH Agonists on Final Height in Girls with Advanced Puberty: A Randomized Long-Term Pilot Study

Pediatric Endocrinology (C.B., D.R.R., C.T., J.C.C., J.L.C., P.F.B.) and Biostatistics (J.C.), Hôpital Cochin-Saint Vincent de Paul, Paris, France 75014

Address correspondence and requests for reprints to: Pierre Bougnères, Endocrinologie, Hôpital St Vincent de Paul, 82 avenue Denfert Rochereau, Paris, France 75014; E-mail: bougneres{at}cochin.inserm.fr

GnRH agonists improve final height in girls with "true" precocious puberty. To test if a comparable effect can be obtained in older girls, we performed a long-term controlled study in 30 caucasian girls whose puberty started between 8.4 and 10 yr (9.4 ± 0.1 yr), a variant of normal called "advanced" puberty. At entry into trial, these girls had clinical, biological, and sonographic manifestations of puberty and a bone age greater than 10.9 yr. They were randomized 2:1 to receive 3.75 mg triptorelin im every 4 weeks for 2 yr (n = 20, group I) or no treatment (n = 10, group II). Mean height at inclusion was 135.2 ± 4.3 cm (+0.6 SDS) in group I, 136.1 ± 4.2 cm (+0.8 SDS ) in group II, with target height 157.6 ± 4.3 cm (group I) and 157.8 ± 4.7 cm (group II), and predicted height (Bayley-Pinneau) 154.1 ± 3.9 cm and 155.2 ± 3.7 cm. Although GnRH agonists transiently delayed sexual maturation as well as bone age and growth rate, they had no clear-cut long-standing effect, and final height was comparable in treated (157.6 ± 4.0 cm) and untreated girls (156.1 ± 5.3 cm) (NS).

This article has been cited by other articles:

				L. Lazar, A. Padoa, and M. Phillip Growth Pattern and Final Height after Cessation of Gonadotropin-Suppressive Therapy in Girls with Central Sexual Precocity J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3483 - 3489. [Abstract] [Full Text] [PDF]

				L. Ibanez, C. Valls, K. Ong, D. B. Dunger, and F. de Zegher Metformin Therapy during Puberty Delays Menarche, Prolongs Pubertal Growth, and Augments Adult Height: A Randomized Study in Low-Birth-Weight Girls with Early-Normal Onset of Puberty J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2068 - 2073. [Abstract] [Full Text] [PDF]

				J.-C. Carel, N. Lahlou, M. Roger, and J. L. Chaussain Precocious puberty and statural growth Hum. Reprod. Update, March 1, 2004; 10(2): 135 - 147. [Abstract] [Full Text] [PDF]

				J. A. Yanovski, S. R. Rose, G. Municchi, O. H. Pescovitz, S. C. Hill, F. G. Cassorla, and G. B. Cutler Jr. Treatment with a Luteinizing Hormone-Releasing Hormone Agonist in Adolescents with Short Stature N. Engl. J. Med., March 6, 2003; 348(10): 908 - 917. [Abstract] [Full Text] [PDF]

				L. Lazar, R. Kauli, A. Pertzelan, and M. Phillip Gonadotropin-Suppressive Therapy in Girls with Early and Fast Puberty Affects the Pace of Puberty but Not Total Pubertal Growth or Final Height J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2090 - 2094. [Abstract] [Full Text] [PDF]

				K. O. Klein, K. M. Barnes, J. V. Jones, P. P. Feuillan, and G. B. Cutler Jr. Increased Final Height in Precocious Puberty after Long-Term Treatment with LHRH Agonists: The National Institutes of Health Experience J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4711 - 4716. [Abstract] [Full Text] [PDF]

				L. Lazar, A. Pertzelan, N. Weintrob, M. Phillip, and R. Kauli Sexual Precocity in Boys: Accelerated Versus Slowly Progressive Puberty Gonadotropin-Suppressive Therapy and Final Height J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4127 - 4132. [Abstract] [Full Text] [PDF]

				L. Ibáñez, A. Ferrer, M. V. Marcos, F. R. Hierro, and F. de Zegher Early Puberty: Rapid Progression and Reduced Final Height in Girls With Low Birth Weight Pediatrics, November 1, 2000; 106(5): 72e - 72. [Abstract] [Full Text]