help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jaquet, D.
Right arrow Articles by Levy-Marchal, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jaquet, D.
Right arrow Articles by Levy-Marchal, C.
The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 4 1401-1406
Copyright © 2000 by The Endocrine Society

Original Studies

Insulin Resistance Early in Adulthood in Subjects Born with Intrauterine Growth Retardation1

D. Jaquet2, A. Gaboriau, P. Czernichow and C. Levy-Marchal

U-457, INSERM, Hôpital R. Debré, 75019 Paris, France

Address all correspondence and requests for reprints to: Dr. D. Jaquet, U-457, INSERM, Hôpital R. Debré, 48 boulevard Sérurier, 75019 Paris, France. E-mail: djacquet{at}infobiogen.fr

In a case-control study that investigated the effect of intrauterine growth retardation (IUGR) on glucose homeostasis, 20-yr-old adults born with IUGR were shown to be hyperinsulinemic in an oral glucose tolerance test, suggestive of insulin resistance. The aim of this study was to ascertain the decreased insulin sensitivity in young IUGR-born adults compared to that in controls. We studied 26 IUGR-born subjects and 25 controls, aged 25 yr. Insulin sensitivity was assessed by peripheral glucose uptake and monitoring free fatty acid (FFA) concentrations under euglycemic hyperinsulinemic clamp. The percent body fat was significantly higher in the IUGR group (27.2 ± 7.6% vs. 22.0 ± 7.3%; P = 0.02), contrasting with comparable body mass index in both groups. Insulin-stimulated glucose uptake was significantly lower in IUGR-born subjects than in controls (6.7 ± 2.9 vs. 8.0 ± 1.9 mg/kg fat-free mass·min; P = 0.05), and the difference remained significant after adjustment for body mass index, total body fat, or waist to hip ratio. In IUGR-born subjects, insulin-stimulated FFA suppression correlated significantly with peripheral glucose uptake (r2 = 0.23; P = 0.02). First phase insulin release in the iv glucose tolerance test, adjusted for insulin sensitivity, did not significantly differ between IUGR and control groups (442 ± 284 vs. 391 ± 209 pmol/L; P = 0.86). In conclusion, IUGR subjects have decreased insulin-stimulated glucose uptake as early as 25 yr of age without major impairment of insulin secretion. Low glucose uptake is associated with a lesser degree of FFA suppression in adipose tissue, which suggests a role of adipose tissue at an early stage of insulin resistance in these subjects.




This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
W. Chen, S. R. Srinivasan, and G. S. Berenson
Influence of Birth Weight on White Blood Cell Count in Biracial (Black-White) Children, Adolescents, and Young Adults: The Bogalusa Heart Study
Am. J. Epidemiol., December 8, 2008; (2008) kwn341v1.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Gatford, S. N. B. Mohammad, M. L. Harland, M. J. De Blasio, A. L. Fowden, J. S. Robinson, and J. A. Owens
Impaired {beta}-Cell Function and Inadequate Compensatory Increases in {beta}-Cell Mass after Intrauterine Growth Restriction in Sheep
Endocrinology, October 1, 2008; 149(10): 5118 - 5127.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. Rotteveel, M. M. van Weissenbruch, J. W. R. Twisk, and H. A. Delemarre-Van de Waal
Infant and Childhood Growth Patterns, Insulin Sensitivity, and Blood Pressure in Prematurely Born Young Adults
Pediatrics, August 1, 2008; 122(2): 313 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
J Rotteveel, M M van Weissenbruch, and H A Delemarre-Van de Waal
Decreased insulin sensitivity in small for gestational age males treated with GH and preterm untreated males: a study in young adults.
Eur. J. Endocrinol., June 1, 2008; 158(6): 899 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
N. Bouhours-Nouet, S. Dufresne, F. B. de Casson, E. Mathieu, O. Douay, F. Gatelais, S. Rouleau, and R. Coutant
High Birth Weight and Early Postnatal Weight Gain Protect Obese Children and Adolescents From Truncal Adiposity and Insulin Resistance: Metabolically healthy but obese subjects?
Diabetes Care, May 1, 2008; 31(5): 1031 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Duffield, T. Vuocolo, R. Tellam, B. S. Yuen, B. S. Muhlhausler, and I. C. McMillen
Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1413 - R1419.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. W. J. Leunissen, P. Oosterbeek, L. K. M. Hol, A. A. Hellingman, T. Stijnen, and A. C. S. Hokken-Koelega
Fat Mass Accumulation during Childhood Determines Insulin Sensitivity in Early Adulthood
J. Clin. Endocrinol. Metab., February 1, 2008; 93(2): 445 - 451.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. S. Gilbert, E. Brandon, and T. Vera
Fetal insulin secretion in late gestation: does size matter?
J. Physiol., December 15, 2007; 585(3): 651 - 652.
[Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
R Verkauskiene, J Beltrand, O Claris, D Chevenne, S Deghmoun, S Dorgeret, M Alison, P Gaucherand, O Sibony, and C Levy-Marchal
Impact of fetal growth restriction on body composition and hormonal status at birth in infants of small and appropriate weight for gestational age
Eur. J. Endocrinol., November 1, 2007; 157(5): 605 - 612.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A. Owens, K. L. Gatford, M. J. De Blasio, L. J. Edwards, I. C. McMillen, and A. L. Fowden
Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth
J. Physiol., November 1, 2007; 584(3): 935 - 949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. S. Buhl, S. Neschen, S. Yonemitsu, J. Rossbacher, D. Zhang, K. Morino, A. Flyvbjerg, P. Perret, V. Samuel, J. Kim, et al.
Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1451 - E1458.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
V. Nobili, M. Marcellini, G. Marchesini, E. Vanni, M. Manco, A. Villani, and E. Bugianesi
Intrauterine Growth Retardation, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Children
Diabetes Care, October 1, 2007; 30(10): 2638 - 2640.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. A. Owens, P. Thavaneswaran, M. J. De Blasio, I. C. McMillen, J. S. Robinson, and K. L. Gatford
Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1879 - E1889.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. Hovi, S. Andersson, J. G. Eriksson, A.-L. Jarvenpaa, S. Strang-Karlsson, O. Makitie, and E. Kajantie
Glucose Regulation in Young Adults with Very Low Birth Weight
N. Engl. J. Med., May 17, 2007; 356(20): 2053 - 2063.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
P. Saenger, P. Czernichow, I. Hughes, and E. O. Reiter
Small for Gestational Age: Short Stature and Beyond
Endocr. Rev., April 1, 2007; 28(2): 219 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. E. Clayton, S. Cianfarani, P. Czernichow, G. Johannsson, R. Rapaport, and A. Rogol
Management of the Child Born Small for Gestational Age through to Adulthood: A Consensus Statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 804 - 810.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. J. De Blasio, K. L. Gatford, I. C. McMillen, J. S. Robinson, and J. A. Owens
Placental Restriction of Fetal Growth Increases Insulin Action, Growth, and Adiposity in the Young Lamb
Endocrinology, March 1, 2007; 148(3): 1350 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R.-E. W. Kavey, V. Allada, S. R. Daniels, L. L. Hayman, B. W. McCrindle, J. W. Newburger, R. S. Parekh, and J. Steinberger
Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics
Circulation, December 12, 2006; 114(24): 2710 - 2738.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T.-A. Vu-Hong, E. Durand, S. Deghmoun, P. Boutin, D. Meyre, D. Chevenne, P. Czernichow, P. Froguel, and C. Levy-Marchal
The INS VNTR Locus Does Not Associate with Smallness for Gestational Age (SGA) but Interacts with SGA to Increase Insulin Resistance in Young Adults
J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2437 - 2440.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Poulsen and A. Vaag
The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner
Diabetes, June 1, 2006; 55(6): 1819 - 1825.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. S. Barry, M. L. Davidsen, S. W. Limesand, H. L. Galan, J. E. Friedman, T. R. H. Regnault, and W. W. Hay Jr.
Developmental Changes in Ovine Myocardial Glucose Transporters and Insulin Signaling Following Hyperthermia-Induced Intrauterine Fetal Growth Restriction.
Experimental Biology and Medicine, May 1, 2006; 231(5): 566 - 575.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Simmons, I. Suponitsky-Kroyter, and M. A. Selak
Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to {beta}-Cell Failure
J. Biol. Chem., August 5, 2005; 280(31): 28785 - 28791.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. H. Schou, K. Pilgaard, T. Vilsboll, C. B. Jensen, C. F. Deacon, J. J. Holst, A. Volund, S. Madsbad, and A. A. Vaag
Normal Secretion and Action of the Gut Incretin Hormones Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide in Young Men with Low Birth Weight
J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4912 - 4919.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Sir-Petermann, C. Hitchsfeld, M. Maliqueo, E. Codner, B. Echiburu, R. Gazitua, S. Recabarren, and F. Cassorla
Birth weight in offspring of mothers with polycystic ovarian syndrome
Hum. Reprod., August 1, 2005; 20(8): 2122 - 2126.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
S. Tenhola, P. Halonen, J. Jaaskelainen, and R. Voutilainen
Serum markers of GH and insulin action in 12-year-old children born small for gestational age
Eur. J. Endocrinol., March 1, 2005; 152(3): 335 - 340.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. C. Jimenez-Chillaron, M. Hernandez-Valencia, C. Reamer, S. Fisher, A. Joszi, M. Hirshman, A. Oge, S. Walrond, R. Przybyla, C. Boozer, et al.
{beta}-Cell Secretory Dysfunction in the Pathogenesis of Low Birth Weight-Associated Diabetes: A Murine Model
Diabetes, March 1, 2005; 54(3): 702 - 711.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers
Endocrine Control of Body Composition in Infancy, Childhood, and Puberty
Endocr. Rev., February 1, 2005; 26(1): 114 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
X. Wang, Y. Cui, X. Tong, H. Ye, and S. Li
Effects of the Trp64Arg Polymorphism in the {beta}3-Adrenergic Receptor Gene on Insulin Sensitivity in Small for Gestational Age Neonates
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4981 - 4985.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. L. Gatford, M. J. De Blasio, P. Thavaneswaran, J. S. Robinson, I. C. McMillen, and J. A. Owens
Postnatal ontogeny of glucose homeostasis and insulin action in sheep
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E1050 - E1059.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. S. Hermann, C. Rask-Madsen, N. Ihlemann, H. Dominguez, C. B. Jensen, H. Storgaard, A. A. Vaag, L. Kober, and C. Torp-Pedersen
Normal Insulin-Stimulated Endothelial Function and Impaired Insulin-Stimulated Muscle Glucose Uptake in Young Adults with Low Birth Weight
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1252 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. A. Stoffers, B. M. Desai, D. D. DeLeon, and R. A. Simmons
Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat
Diabetes, March 1, 2003; 52(3): 734 - 740.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. van Pareren, P. Mulder, M. Houdijk, M. Jansen, M. Reeser, and A. Hokken-Koelega
Effect of Discontinuation of Growth Hormone Treatment on Risk Factors for Cardiovascular Disease in Adolescents Born Small for Gestational Age
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 347 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. A. Murtaugh, D. R. Jacobs Jr., A. Moran, J. Steinberger, and A. R. Sinaiko
Relation of Birth Weight to Fasting Insulin, Insulin Resistance, and Body Size in Adolescence
Diabetes Care, January 1, 2003; 26(1): 187 - 192.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. L. Kind, P. M. Clifton, P. A. Grant, P. C. Owens, A. Sohlstrom, C. T. Roberts, J. S. Robinson, and J. A. Owens
Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R140 - R152.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
L Jackson, A Burchell, A McGeechan, and R Hume
An inadequate glycaemic response to glucagon is linked to insulin resistance in preterm infants?
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2003; 88(1): F62 - 66.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Jaquet, D. A. Tregouet, T. Godefroy, V. Nicaud, D. Chevenne, L. Tiret, P. Czernichow, and C. Levy-Marchal
Combined Effects of Genetic and Environmental Factors on Insulin Resistance Associated With Reduced Fetal Growth
Diabetes, December 1, 2002; 51(12): 3473 - 3478.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. A. Veening, M. M. van Weissenbruch, and H. A. Delemarre-van de Waal
Glucose Tolerance, Insulin Sensitivity, and Insulin Secretion in Children Born Small for Gestational Age
J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4657 - 4661.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. B. Jensen, H. Storgaard, F. Dela, J. J. Holst, S. Madsbad, and A. A. Vaag
Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight
Diabetes, April 1, 2002; 51(4): 1271 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. Beringue, B. Blondeau, M. C. Castellotti, B. Breant, P. Czernichow, and M. Polak
Endocrine Pancreas Development in Growth-Retarded Human Fetuses
Diabetes, February 1, 2002; 51(2): 385 - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Bajoria, S. R. Sooranna, S. Ward, and M. Hancock
Placenta as a Link between Amino Acids, Insulin-IGF Axis, and Low Birth Weight: Evidence from Twin Studies
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 308 - 315.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. Jaquet, H. Vidal, R. Hankard, P. Czernichow, and C. Levy-Marchal
Impaired Regulation of Glucose Transporter 4 Gene Expression in Insulin Resistance Associated with in UteroUndernutrition
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3266 - 3271.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. E. Oberfield
Metabolic Lessons from the Study of Young Adolescents with Polycystic Ovary Syndrome--Is Insulin, Indeed, the Culprit?
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3520 - 3525.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society