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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 5 1801-1804
Copyright © 2000 by The Endocrine Society

Original Studies

Significance of Pro12Ala Mutation in Peroxisome Proliferator-Activated Receptor-{gamma}2 in Korean Diabetic and Obese Subjects1

Eun Young Oh, Kyeong Min Min, Jae Hoon Chung, Yong-Ki Min, Myung-Shik Lee, Kwang-Won Kim and Moon-Kyu Lee

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, and Samsung Biomedical Research Institute (K.M.M.), Sungkyunkwan University School of Medicine, Seoul, Korea

Address all correspondence and requests for reprints to: Dr. Moon-Kyu Lee, Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

Peroxisome proliferator-activated receptors (PPARs) are a nuclear hormone receptor superfamily of ligand-activated transcription factors, and the PPAR{gamma} subtype regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. There have been several reports on the relationship between the PPAR{gamma}2 Pro12Ala genotype and obesity or diabetes in Caucasians. The objective of this study was to examine the relationship between this mutation and obesity or diabetes in Korean subjects. Two hundred and twenty-nine Korean subjects, including 111 obese subjects (body mass index, >25 kg/m2) were included in this study. One hundred and eleven subjects had normal glucose tolerance, 60 had impaired glucose tolerance, and 58 had diabetes mellitus. We evaluated these subjects for the Pro12Ala mutation in the PPAR{gamma} gene using PCR-restriction fragment length polymorphism. Allele frequencies of the Pro12Ala missense mutation of PPAR{gamma}2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05). Allele frequencies of PPAR{gamma}2 Ala in obese subjects (qAla = 0.036) were not significantly different from those in nonobese subjects (qAla = 0.047). These results suggest that the Pro12Ala mutation in PPAR{gamma} is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.




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