This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Deng, H.-W. Articles by Recker, R. R. Search for Related Content PubMed PubMed Citation Articles by Deng, H.-W. Articles by Recker, R. R.

Association of Estrogen Receptor- Genotypes with Body Mass Index in Normal Healthy Postmenopausal Caucasian Women¹

Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University (H.-W.D., J.L., R.D., K.M.D., M.J., G.G., H.D., R.R.R.), Omaha, Nebraska 68131; and Laboratory of Molecular and Statistical Genetics, HuNan Normal University College of Life Sciences (H.-W.D.), ChangSha 41800, People’s Republic of China

Address all correspondence and requests for reprints to: Hong-Wen Deng, Ph.D., Osteoporosis Research Center, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131. E-mail: deng{at}creighton.edu

Several lines of evidence suggest the importance of the estrogen receptor (ER) in determining body mass index (BMI). Our purpose was to investigate whether genetic polymorphisms at the restriction enzyme PvuII site of the ER- gene locus are associated with BMI variation. Data on BMI, age, and ER- genotypes were obtained from 108 healthy midwestern U.S. postmenopausal Caucasian women. The study subjects were unrelated and aged 65 yr and over (mean age ± SD, 73.4 ± 5.1 yr), with an average BMI of 25.25 (SD, 4.04). The ER- genotypes were obtained by PCR followed by restriction enzyme PvuII digestion. We found that in our study subjects the ER- genotypes are significantly associated with BMI (by ANOVA, P = 0.04), explaining about 6.2% of the BMI variation in our study sample. The allelic effects of this locus on BMI are approximately additive. In our sample, individuals of the PP and Pp genotypes have, respectively, 11.4% and 4.8% higher BMI than individuals of the pp genotype. There is a significant ER- genotype by age interaction, so that in our sample PP individuals tend to gain weight with age, whereas Pp and pp individuals tend to lose weight with age. Therefore, the ER- polymorphisms are associated with BMI variation in healthy postmenopausal Caucasian women aged 65 yr and over. Our result is consistent with some recent findings suggesting the potential effects of the ER on BMI. The importance of the ER- genotypes in other populations and other age groups needs to be demonstrated. Although the results of the ER- genotype by age interaction are obtained here from cross-sectional data, direct confirmation may come from longitudinal studies in which individuals are measured multiple times over several years. The importance of the ER- genotypes on BMI should be confirmed by further studies using methods robust to the potential problem of population substructuring that may confound the conclusions of population association studies.

This article has been cited by other articles:

				K. L. E. Klos, E. Boerwinkle, R. E. Ferrell, S. T. Turner, and A. C. Morrison ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart Study J. Lipid Res., August 1, 2008; 49(8): 1701 - 1706. [Abstract] [Full Text] [PDF]

				C. J. Gallagher, C. D. Langefeld, C. J. Gordon, J. K. Campbell, J. C. Mychalecky, M. Bryer-Ash, S. S. Rich, D. W. Bowden, and M. M. Sale Association of the Estrogen Receptor-{alpha} Gene With the Metabolic Syndrome and Its Component Traits in African-American Families: The Insulin Resistance Atherosclerosis Family Study Diabetes, August 1, 2007; 56(8): 2135 - 2141. [Abstract] [Full Text] [PDF]

				M Alevizaki, K Saltiki, A Cimponeriu, I Kanakakis, N Xita, C C Alevizaki, I Georgiou, and H-L Sarika Severity of cardiovascular disease in postmenopausal women: associations with common estrogen receptor {alpha} polymorphic variants Eur. J. Endocrinol., April 1, 2007; 156(4): 489 - 496. [Abstract] [Full Text] [PDF]

				C. J. Gallagher, K. L. Keene, J. C. Mychaleckyj, C. D. Langefeld, J. N. Hirschhorn, B. E. Henderson, C. J. Gordon, B. I. Freedman, S. S. Rich, D. W. Bowden, et al. Investigation of the Estrogen Receptor-{alpha} Gene With Type 2 Diabetes and/or Nephropathy in African-American and European-American Populations Diabetes, March 1, 2007; 56(3): 675 - 684. [Abstract] [Full Text] [PDF]

				D. A. Lawlor, N. Timpson, S. Ebrahim, I. N.M. Day, and G. D. Smith The association of oestrogen receptor {alpha}-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study Eur. Heart J., July 1, 2006; 27(13): 1597 - 1604. [Abstract] [Full Text] [PDF]

				J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, and C. Y. Bowers Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition Endocr. Rev., April 1, 2006; 27(2): 101 - 140. [Abstract] [Full Text] [PDF]

				A. Rokach, A. Pollak, L. Rosen, Y. Friedlander, A. Blumenfeld, L. Reznik, and R. Dresner-Pollak Estrogen Receptor {alpha} Gene Polymorphisms Are Associated with the Angiographic Extent of Coronary Artery Disease J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6556 - 6560. [Abstract] [Full Text] [PDF]

				C. S. Fox, Q. Yang, L. A. Cupples, C.-Y. Guo, L. D. Atwood, J. M. Murabito, D. Levy, M. E. Mendelsohn, D. E. Housman, and A. M. Shearman Sex-Specific Association between Estrogen Receptor-{alpha} Gene Variation and Measures of Adiposity: The Framingham Heart Study J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6257 - 6262. [Abstract] [Full Text] [PDF]

				S. C E Schuit, F. H de Jong, L. Stolk, W N. H Koek, J. B J van Meurs, M. W C J Schoofs, M C. Zillikens, A. Hofman, J. P T M van Leeuwen, H. A P Pols, et al. Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women Eur. J. Endocrinol., August 1, 2005; 153(2): 327 - 334. [Abstract] [Full Text] [PDF]

				J. D. Veldhuis, A. Bae, R. S. Swerdloff, A. Iranmanesh, and C. Wang Experimentally Induced Androgen Depletion Accentuates Ethnicity-Related Contrasts in Luteinizing Hormone Secretion in Asian and Caucasian Men J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1632 - 1638. [Abstract] [Full Text] [PDF]

				L. Gennari, D. Merlotti, V. De Paola, A. Calabro, L. Becherini, G. Martini, and R. Nuti Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis: A HuGE Review Am. J. Epidemiol., February 15, 2005; 161(4): 307 - 320. [Abstract] [Full Text] [PDF]

				S. C. E. Schuit, H.-H. S. Oei, J. C. M. Witteman, C. H. Geurts van Kessel, J. B. J. van Meurs, R. L. Nijhuis, J. P. T. M. van Leeuwen, F. H. de Jong, M. C. Zillikens, A. Hofman, et al. Estrogen Receptor {alpha} Gene Polymorphisms and Risk of Myocardial Infarction JAMA, June 23, 2004; 291(24): 2969 - 2977. [Abstract] [Full Text] [PDF]

				Y.-J. Liu, F.-H. Xu, H. Shen, Y.-Z. Liu, H.-Y. Deng, L.-J. Zhao, Q.-Y. Huang, V. Dvornyk, T. Conway, K. M. Davies, et al. A Follow-Up Linkage Study for Quantitative Trait Loci Contributing to Obesity-Related Phenotypes J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 875 - 882. [Abstract] [Full Text] [PDF]

				Y-Z Liu, F-H Xu, H Shen, H Deng, Y-J Liu, L-J Zhao, V Dvornyk, T Conway, J-L Li, Q-Y Huang, et al. Confirmation linkage study in support of the X chromosome harbouring a QTL underlying human height variation J. Med. Genet., November 1, 2003; 40(11): 825 - 831. [Full Text] [PDF]

				D. M. Herrington, T. D. Howard, G. A. Hawkins, D. M. Reboussin, J. Xu, S. L. Zheng, K. B. Brosnihan, D. A. Meyers, and E. R. Bleecker Estrogen-Receptor Polymorphisms and Effects of Estrogen Replacement on High-Density Lipoprotein Cholesterol in Women with Coronary Disease N. Engl. J. Med., March 28, 2002; 346(13): 967 - 974. [Abstract] [Full Text] [PDF]

				D. M. Herrington and K. P. Klein Genome and Hormones: Gender Differences in Physiology: Invited Review: Pharmacogenetics of estrogen replacement therapy J Appl Physiol, December 1, 2001; 91(6): 2776 - 2784. [Abstract] [Full Text] [PDF]

				A. J. O'Sullivan, A. Martin, and M. A. Brown Efficient Fat Storage in Premenopausal Women and in Early Pregnancy: A Role for Estrogen J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4951 - 4956. [Abstract] [Full Text] [PDF]