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The Journal of Clinical Endocrinology & Metabolism Vol. 86, No. 5 1865-1867
Copyright © 2001 by The Endocrine Society

Special Articles

Thyroid Storm in a Child following Radioactive Iodine (RAI) Therapy: A Consequence of RAI Versus Withdrawal of Antithyroid Medication

Penny M. Kadmon, Richard B. Noto, Charlotte M. Boney, Gregory Goodwin and Philip A. Gruppuso

Departments of Pediatrics (P.M.K., C.M.B., G.G., P.A.G.) and Diagnostic Imaging (R.B.N.), Rhode Island Hospital and Brown University, Providence, Rhode Island 02903

Address correspondence and requests for reprints to: Philip A. Gruppuso, M.D., Department of Pediatrics, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island 02903.

A 7.5-yr-old boy with Graves’ disease, difficult to control with antithyroid medication and radioactive iodine (RAI) therapy, developed thyroid storm encephalopathy on day 13 after withdrawal of methimazole therapy, 4 days after iodione-131 treatment. We attributed his thyroid storm to withdrawal of antithyroid medication as opposed to RAI therapy. We interpret this case as indicating that there may be a need to reevaluate the duration of antithyroid medication withdrawal before RAI therapy for hyperthyroid children at increased risk for thyroid storm.




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Copyright © 2001 by The Endocrine Society