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Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome

Departments of Medicine and Therapeutics (C.C.J.K., J.M.C.C.), Obstetrics and Gynecology (H.L.), Divisions of Biochemistry and Molecular Biology (G.W.G.), Pathological Biochemistry (N.S.), and Medicine (J.R.P.), University of Glasgow, Glasgow, Scotland, United Kingdom G4 0SF

Address all correspondence and requests for reprints to: Dr. Naveed Sattar, University Department of Pathological Biochemistry, Glasgow Royal Infirmary University, National Health Service Trust, Glasgow, Scotland, United Kingdom G4 0SF. E-mail: nsattar{at}clinmed.gla.ac.uk

Abstract

Low grade chronic inflammation as reflected by increased C-reactive protein (CRP) concentrations independently predicts those at risk for coronary heart disease (CHD) and type 2 diabetes. Women with polycystic ovarian syndrome (PCOS) are insulin resistant and have increased risk for CHD and type 2 diabetes, but currently there are no data on markers of inflammation in women with PCOS. Seventeen women with PCOS (defined on the basis of elevated testosterone and oligomenorrhea) and 15 healthy women matched as a group for body mass index were recruited. Measurement of CRP concentrations was made using a highly sensitive assay. Insulin resistance was assessed using the hyperinsulinemic euglycemic clamp technique. The women with PCOS had significantly elevated CRP concentrations relative to controls (geometric means, 2.12 and 0.67 mg/L, respectively; P = 0.016). Log CRP correlated with body mass index in both PCOS and controls (r = 0.58; P < 0.05 and r = 0.78; P < 0.01, respectively) and inversely with insulin sensitivity (r = -0.57; P < 0.05 and r = -0.69; P < 0.01). Total testosterone did not correlate with log CRP in either group. On adjustment for body mass index and age, there remained a significant difference in log CRP between PCOS and controls (t = 2.13; P < 0.05). On further adjustment for insulin sensitivity, log CRP was no longer significantly different between groups (t = 1.51; P = 0.14). We conclude that women with PCOS have significantly increased CRP concentrations relative to women with normal menstrual rhythm and normal androgen levels. We propose low grade chronic inflammation as a novel mechanism contributing to increased risk of CHD and type 2 diabetes in these women.

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