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Parathyroid Adenoma in a Subject with Familial Hypocalciuric Hypercalcemia: Coincidence or Causality?

Section of Endocrinology, Department of Medicine, National University Hospital (K.B., B.T., J.B.), N-0027 Oslo, Norway; Department of Medicine, Aust-Agder Central Hospital (A.Q.P.), N-4087 Arendal, Norway; and Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital (H.B.), N-5021 Bergen, Norway

Address all correspondence and requests for reprints to: Jens Bollerslev, M.D., Section of Endocrinology, National University Hospital, N-0027 Oslo, Norway. E-mail: . jens.bollerslev{at}rikshospitalet.no

Abstract

A middle-aged woman presented with a history of constipation, easy fatigue, depressive mood, lassitude, polydipsia, and polyuria. The patient posed a challenging diagnostic dilemma due to the presence of persistent severe hypercalcemia and relative lack of clinically manifested symptoms. Clinical, biochemical, and genetic examinations confirmed the diagnosis of familial hypocalciuric hypercalcemia as a result of C562Y calcium-sensing receptor mutation, and a coexisting parathyroid adenoma. After adenectomy, the patient’s clinical situation improved markedly, and a modest equilibrium hypercalcemia persisted. This case presents an unusual combination of two relatively common endocrine disorders.

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