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Original Studies |
Department of Heart and Lung Diseases, Sahlgrenska University Hospital (R.R., P.B.), S-413 45 Göteborg, Sweden; and the Department of Physiology, University of California (M.F.D.), San Francisco, California 94143
Address all correspondence and requests for reprints to: Roland Rosmond, M.D., Department of Heart and Lung Diseases, Sahlgrenska University Hospital, S-413 45 Goteborg, Sweden.
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Abstract |
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 Top Abstract IntroductionSubjects and MethodsResultsDiscussionReferences |
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Cortisol concentrations were highest in the morning, and lunch was followed by a peak (P = 0.044). Two types of diurnal cortisol curves were identified, one characterized by a high variability with high morning values, and another with low variability and low morning values. Both correlated strongly with suppression of salivary cortisol by dexamethasone (P < 0.001).
Stress-related cortisol secretion was associated with D (P = 0.051), low IGF-I (P = 0.006), and diastolic blood pressure (P = 0.078). When the type of diurnal cortisol curve was taken into consideration by statistical weighting, stress-related cortisol secretion in subjects with high variability showed associations with testosterone (P < 0.001), D, total and LDL cholesterol, diastolic blood pressure (P < 0.001), fasting insulin (P = 0.039), and glucose (P = 0.030) as well as, negatively, triglycerides (P < 0.001).
When weighted for a low variability of diurnal cortisol secretion, stress-related cortisol secretion showed strong negative relationships with IGF-I, testosterone, and HDL. Furthermore, strong, consistent relationships (all P < 0.001) were found with obesity factors (body mass index, WHR, and D), and with metabolic (insulin, glucose, triglycerides, and total and LDL cholesterol) as well as hemodynamic variables (systolic and diastolic blood pressure and heart rate).
These results clearly show interactions between diurnal cortisol secretion related to perceived stress and anthropometric, endocrine, metabolic, and hemodynamic variables. This seems to occur with apparently normal regulation of the HPA axis (high morning peaks and variability as well as dexamethasone suppression of cortisol), where other endocrine variables are not affected. With a low diurnal cortisol variation and blunted dexamethasone suppression, indicating abnormal regulation of the HPA axis, perceived stress-dependent cortisol values were strongly related to perturbations of other endocrine axes as well as abdominal obesity with metabolic and hemodynamic abnormalities. Perturbations of the regulation of the HPA axis such as those described in combination with low dexamethasone suppressibility are known to follow long term overactivation of the axis by factors such as environmental stress.
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Introduction |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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The results of recent studies have suggested that the HPA axis is hypersensitive and sex steroid and GH secretion are inhibited in obesity with predominance of central, visceral adipose tissue depots (6, 7). The consequences of this will be a frequent overstimulation of the HPA axis, with elevated secretion of cortisol as well as low sex steroid and GH concentrations (5). This is the typical endocrine reaction following stress that is perceived as leading to an uncontrollable situation with defeat and helplessness as consequences (3). Consistent findings of psychosocial and socio-economic handicaps in subjects with centralization of body fat suggest an environment in which such stress reactions might be expected (8, 9, 10, 11, 12).
As the individual perception of certain environmental challenges varies, it is of importance to take this factor (coping) into consideration when examining the status of the HPA axis. Single measurements of total or free active cortisol in serum are not informative, because cortisol is secreted in a highly irregular manner, and invasive sampling by itself might be a source of bias. This might be overcome by measurements of urinary output of free cortisol. However, the perception of a stressful environment probably varies over different periods of the day and across days, making the consequences of psychological reactions, with activation of the HPA axis, difficult to follow. Furthermore, the difficulty of collecting complete urinary samples throughout the day are considerable. Therefore, new methods to examine these problems need to be developed.
The concentration of free active cortisol in serum is closely mirrored by its concentration in saliva (13). Collection of saliva is noninvasive and can be performed by the proband in his/her everyday life during exposure to perceived stressful events. In addition, such collection can be performed repeatedly in parallel with reports of perceived stress. Such a method was developed and used in the present study.
The time points selected for the collection of salivary cortisol were in the morning, when the HPA axis shows a lively activity, during a physiological stimulus (a standardized lunch), as well as in the evening, when the HPA axis is more quiescent. Perceived stress was reported in association with each cortisol measurement, and stress-related cortisol secretion was calculated. These measurements were then set in relation to body fat mass and distribution as well as the steady state hormonal, metabolic, and hemodynamic abnormalities associated with centralization of body fat stores (6).
Previous findings have suggested a hypersensitive HPA axis in central obesity, a condition with a high risk to develop cardiovascular disease and noninsulin-dependent diabetes mellitus and their risk factors (6, 7). We hypothesized that the HPA axis perturbations are associated with these diseases and their predictors. Therefore, this study was performed in which newly developed techniques for measurements of the status of the HPA axis were developed and used. The results show close connections between the cortisol levels of perceived stress and abdominal obesity and its endocrine, metabolic, and hemodynamic complications.
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Subjects and Methods |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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In 1992, a cohort of men (n = 1302) was recruited from the
National Population Register (Göteborg, Sweden). The target
population comprised all men born during the first 6 months of 1944 and
living in Göteborg. Between January and June 1992, they were
mailed a self-administered questionnaire (11, 12). A total of 1040 men
(79.9%) responded to the questionnaire. Based on the self-reported
anthropometric measurements, 3 subgroups (each n = 150) of men with the
lowest (
0.885), median (0.94–0.96), and highest (
1.01) waist/hip
circumference ratio (WHR) were selected. They were then invited to a
health examination during 1995; 284 (63.1%) volunteered to
participate. No man was excluded from the study due to somatic or
psychiatric disease. The study was approved by the ethical committee of
the medical faculty of the University of Göteborg and by the
Swedish Data Inspection Board.
Examinations
All examinations were performed in the morning after an overnight fast, and all examinations were accomplished by the same research nurses and technicians.
Anthropometry. Body weight was measured to the nearest 0.1 kg with participants in underwear, and height was measured to the nearest centimeter. The body mass index (BMI) was calculated as weight in kilograms divided by height in meters squared. The waist circumference was measured midway between the lowest rib and iliac crest, and the hip circumference was measured at the level of the great trochanters (14). The WHR was calculated as the ratio between the waist and the hip circumferences. The sagittal trunk diameter (D; centimeters) was determined as the distance between the examination table and the highest point of the abdomen in a recumbent position (15).
Diurnal cortisol measurements and self-reported stress. A sampling device called Salivette (Sarstedt, Rommelsdorf, Germany) was used to collect saliva. The Salivette consists of a small cotton swab inside a standard centrifugation tube (13). On a random working day the participants delivered repeated salivary cortisol samples. A sample was obtained in the morning (0800–0900 h), then at 1145 h, and 30, 45, and 60 min after a standardized lunch at 1200 h, 1700 h, and finally just before bedtime. Salivary cortisol was determined by RIA (Orion Diagnostica, Turku, Finland). The lunch was provided by the laboratory and contained 266–277 Cal (protein, 18.2–21.0 g; carbohydrate, 33.6–36.4 g; fat, 5.6–6.5 g). The participants were asked to answer a question about self-perceived stress each hour from 0600–2300 h. This question was formulated: Did you feel any stress during this hour? The perception of stress was registered on a yes-no nominal scale. Such reports during the hours preceding the salivary collections and at the time of collection were used for comparisons with the results of salivary cortisol measurements to obtain a measurement of stress-related cortisol secretion. Careful oral and written instructions were provided to avoid misunderstanding, and the feasibility of the procedures was tested before the study in about 40 men, who were not included in the results.
Dexamethasone suppression test. This test was performed on the next day after the diurnal cortisol measurements. The participants were given two Salivettes and one tablet of dexamethasone (Decadron, MSD, Sweden) of 0.5 mg. They were asked to chew the cotton swab in the morning (0800–0900 h) for 45–60 s. At 2200 h on the second day, the dexamethasone tablet was taken, and the following morning the salivary sampling was repeated. The decrease in salivary cortisol level after dexamethasone administration was calculated as the mean of the two noninhibited morning cortisol levels (before diurnal curve and before dexamethasone test) minus the cortisol level after dexamethasone intake. The dose of 0.5 mg was chosen because we have previously shown (16) that this dose reveals differences that cannot be discovered with the conventionally used dose of 1 mg (17).
Hormones, glucose, and serum lipids. Total serum testosterone was determined by a nonextraction method, where testosterone bound to BSA at C-19 (testosterone-19-carboxymethylether-BSA) was used as the antigen (Testosterone 125I RIA, ICN Biomedicals, Costa Measa, CA). Insulin-like growth factor I (IGF-I) was determined by hydrochloric acid-ethanol (12.5% 2 N HCl-87.5% ethanol) extraction RIA (Nichols Institute Diagnostics, San Juan Capistrano, CA). Insulin was measured by RIA (Pharmacia Insulin RIA 100, Kabi Pharmacia Diagnostics, Uppsala, Sweden). Glucose was determined by a commercially available enzymatic method (18), and serum lipids were determined as described by Wiklund et al. (19).
Blood pressure. Two blood pressure measurements were taken, on the right arm with the participants sitting, with a random-zero mercury sphygmomanometer (20). Blood pressure was measured after 5 min of rest and with a 5-min interval and before blood samples were taken. Heart rate was recorded simultaneously. The individual mean systolic and diastolic blood pressures were calculated as the mean of the two measurements.
Physical health status and current medication. The participants were asked to report history of the following diseases, if diagnosed by a physician: 1) angina pectoris, 2) cerebral infarction and/or hemorrhage (stroke), 3) endocrine disorders, 4) hyperlipidemias, 5) hypertension, 6) insulin-dependent diabetes mellitus, 7) myocardial infarction, and 8) noninsulin-dependent diabetes mellitus. In addition, information about their current use of medication (names and doses) was obtained.
Statistical analysis
Standard methods were used to calculate the descriptive
statistics. To estimate the covariability between self-reported stress
and salivary cortisol levels, we calculated a coefficient (
) for
each individual using the Pearson’s product-moment [Covar(x,
y)/SDx x
SDy]. This coefficient
(i) is thus an expression of the stress-related
cortisol secretion for each individual. Sixty-eight (23.9%)
participants indicated no self-perceived stress, and four (1.4%)
reported continuous stress during the registered hours. In such cases
the stress variable becomes a constant, and the coefficient () of
covariability is not possible to calculate.
Based on the repeated measurements of salivary cortisol (n = 7)
for each individual, the within-individual cortisol variance
(
i) was estimated. As the variance in cortisol secretion
is a measurement of the functional status of the HPA axis (21), the
greatest weight in the analysis was given to the within-individual
cortisol variance (i). In addition, we performed
analyses with greater weight given to the inverse within-individual
cortisol variance (
i = 1/i). The
inversion (reciprocal) of the variance was performed to give the
smallest variance a greater weight in the analyses.
Before entering the variables into the analyses, a distribution fitting
test was completed. The Kolmogorov-Smirnov goodness of fit test (22)
showed that the variables were not compatible with a Gaussian (normal)
distribution. Test of possible associations between stress-related
cortisol secretion (i) and anthropometric, endocrine,
metabolic, and blood pressure measurements were performed with the
Spearman’s 
(23). Spearman’s can be thought of as the regular
Pearson’s product-moment correlation coefficient in terms of
proportion of variability accounted for, except that Spearman’s is
computed from ranks (23). Hypothesis testing on the differences in mean
rank was performed using the Wilcoxon matched paired, signed rank test
(24).
Nonparticipation analyses were performed using tests appropriate to the
scale of measurement of each variable (11, 12). The statistical
significance was relaxed (
= 0.10) to increase the sensitivity to
detect potential selection (nonparticipant) bias.
Throughout this report, all confidence intervals and P
values are two sided. The level of statistical significance was
considered to be the conventional = 0.05. The data analyses were
accomplished with SPSS software (SPSS for Windows, release 7.5, SPSS,
Chicago, IL).
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Results |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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Fifty-five (19.4%) of the participants did not perform the stress-related salivary cortisol measurements for various reasons. However, these subjects did not differ statistically in regard to the anthropometric, endocrine, metabolic, and hemodynamic measurements presented here.
Table 1
presents the physical health
status and current use of medication in the total population. Six
(2.1%) subjects reported the use of lipid-lowering drugs, and 44
(15.5%) had hypertension. Antidepressant drugs were used by 6 (2.1%)
of the men.
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shows the average (arithmetic
mean) of the cortisol values during the day. The values were highest in
the morning, and lunch was associated with an elevation of about 1-h
duration. The average of the elevated cortisol concentrations at 30,
45, and 60 min after lunch (mean rank = 117.4) was significantly
increased (z = -2.0; P = 0.044) compared to the
cortisol concentration at 1145 h (mean rank = 106.4).
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.
The mean salivary cortisol level (n = 7) was 7.41, with a
SD of 3.64. Nevertheless, as indicated by the relatively
small confidence interval (95% confidence interval, 6.92–7.90), this
sample mean can be considered a sufficient estimator of the unknown
(true) population means (µi).
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in
terms of Spearman’s . Sagittal recumbent trunk diameter and
diastolic blood pressure were positively connected to stress-related
cortisol secretion (borderline significance). There was a negative
correlation between stress-related cortisol secretion and IGF-I ( =
-0.244; P = 0.006).
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shows the results of the
correlations, weighted by the within-individual cortisol variance
(i), between stress-related cortisol secretion and
anthropometric, endocrine, metabolic, and blood pressure measurements.
The within-individual cortisol variance (i) was strongly
positively correlated to the dexamethasone suppression test ( =
0.695; P < 0.001; not shown in Table 4). A positive,
significant relationship was found between stress-related cortisol
secretion and sagittal recumbent trunk diameter, testosterone, fasting
insulin and glucose, cholesterol, LDL cholesterol, as well as diastolic
blood pressure. Triglycerides were negatively related to stress-related
cortisol secretion ( = -0.197; P < 0.001).
Furthermore, the cortisol peak after lunch was negatively related to
BMI ( = -0.237; P < 0.001), WHR ( = -0.363;
P < 0.001), and D ( = -0.304; P <
0.001).
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i = 1/i). Table 5 illustrates such associations between
stress-related cortisol secretion and anthropometric, endocrine,
metabolic, and blood pressure measurements. The inverse
within-individual cortisol variance was strongly negatively correlated
to the dexamethasone suppression test ( = -0.695; P
< 0.001; not shown in Table 5). A positive, significant relationship
was found with BMI, WHR, and sagittal recumbent trunk diameter ( =
0.341, = 0.447, and = 0.472, respectively). Fasting insulin
and glucose, triglycerides, cholesterol, and LDL cholesterol were
also found to be strongly associated with stress-related cortisol
secretion. Furthermore, systolic and diastolic blood pressure as well
as heart rate showed positive relationships. Inverse significant
correlations were found between stress-related cortisol secretion and
testosterone, IGF-I, and HDL cholesterol ( = -0.179, = -0.331,
and = -0.244, respectively). All of these relationships were
highly statistically significant (P < 0.001).
Moreover, the cortisol peak after lunch was positively related to BMI
( = 0.254; P < 0.001), WHR ( = 0.185;
P < 0.001), and D ( = 0.277; P <
0.001).
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i = 1/i), is illustrated in Fig. 2A, and Fig. 2B and C shows similar
analyses for WHR and D. As indicated by the confidence bands around the
fitted (regression) line, the probability that the true fitted line (in
the population) falls between the bands is 0.95.
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Discussion |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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The variability of the cortisol values in individuals was dominated by
the difference between morning and evening values, as shown in Fig. 1
.
A high variability is thus a sign of the typical normal diurnal curve,
with peaks in the morning and low values in the evening. In contrast, a
low variability with a flattened curve indicates diminished differences
between morning and evening values due to lower morning and/or higher
evening concentrations.
The HPA axis is regulated by feedback inhibition from central glucocorticoid receptors, which, when occupied by glucocorticoids, diminish or totally inhibit the activity of the axis. This can be tested by administration of dexamethasone and subsequent measurements of inhibition of cortisol secretion. The variability of diurnal cortisol secretion and the degree of dexamethasone suppression after a dose of 0.5 mg showed strong correlations. This means that high morning and low evening values of cortisol, indicating an intact HPA axis, were followed by effective dexamethasone suppression. In contrast, a flattened diurnal curve was associated with higher levels of cortisol after dexamethasone administration. Thus, normal or diminished plasticity of HPA axis regulation was found, using two different, independent methods. A flattened diurnal cortisol curve as well as a diminished dexamethasone suppression are both considered to be consequences of frequently repeated or chronic challenges of the HPA axis by factors such as environmental stress (21, 25).
Cortisol concentrations in saliva were measured repeatedly in relation to perceived stress. The relationship between these two variables was calculated over the day as an average index of stress-related cortisol secretion. A high index indicates that a given degree of perceived stress is associated with an elevated cortisol response due to HPA axis activation and vice versa. Such stress-related cortisol secretion would be expected to be different depending on the status of the HPA axis. This initial characterization of the HPA axis summarized above, showing that normal or deficient diurnal regulation correlated with normal or deficient feedback control, provided such an opportunity. Therefore, when associations were sought between stress-related cortisol secretion and anthropometric, endocrine, metabolic, and hemodynamic variables, the basic status of the HPA axis was weighted into these analyses. Significant associations were then found with signs of both a normal and a blunted activity of the HPA axis. However, the relationships were consistently stronger in men with a flattened diurnal curve and a blunted suppression by dexamethasone and comprised negative relationships with testosterone, IGF-I, and HDL and strong positive relationships to all other measured anthropometric, metabolic, and hemodynamic variables (P < 0.001).
These results suggest that the perceived stress-related cortisol secretion measured under ordinary living conditions during a random working day is related to various disadvantageous anthropometric, endocrine, and hemodynamic factors. It seems particularly striking that when the HPA axis has been adapted to blunted activity with poor feedback control, these associations became uniformly stronger. Provided that the day of measurements was representative, this might be interpreted to mean that perceived stress with subsequent HPA axis activation is associated with problems in the homeostasis of several somatic systems. The observation that this is more pronounced with signs of a poorly regulated HPA axis might mean that the exposure to perceived stress had been more frequent or severe during the period preceding the examination, leading to the adaptations of the HPA axis observed, which are those observed after prolonged stress. This might presumably also result in a sensitization of the axis to the perceived stress, with the consequence of pronounced stress-related cortisol secretion (21, 25). In combination with abdominal obesity, this is apparently also the case after the physiological challenge of eating.
Previous work has indicated that morning cortisol levels are low in obesity, in general (26), including central obesity (16, 17), and the diurnal curve is consequently more flattened. This is occurring while cortisol turnover is higher than normal (26) and seems to result in an occasionally elevated net output of cortisol in abdominal obesity, as measured by urinary free cortisol (17). The strong relationships between the measurements of HPA axis activity and measurements of abdominal (WHR and D) obesity (BMI) shown here are thus in general agreement with previous studies of the net results of HPA axis activity in abdominal obesity. Other indicators of a dysregulation of the HPA axis in abdominal obesity are high secretion of cortisol after laboratory stress tests (17, 27), elevated cortisol secretion after lunch, as reported here, ACTH levels after administration of CRH (28, 29), and cortisol concentrations after challenges with ACTH (17, 28). This might mean sensitized and/or hyperresponsive hypothalamic centers, pituitary as well as adrenal regulatory mechanisms, that result in elevated net cortisol production in individuals with abdominal obesity.
The results reported here are thus consistent with previous work suggesting a dysregulation of the HPA axis in abdominal obesity. Such dysregulation is apparent in a disturbed diurnal regulation of HPA activity and a hyperresponsiveness or hypersensitivity to various challenges of psychological, physiological, or endocrine nature, occasionally resulting in elevated total net secretion and urinary output of cortisol. As neither perceived daily stress, laboratory stress tests, nor food intake produces maximal stimulation of the HPA axis, it seems highly likely that the axis is hypersensitive, rather than hyperresponsive, in abdominal obesity.
It should be noted that the associations between stress-related cortisol and other variables were less evident without statistical weighting of the status of the HPA axis. It should also be noted that some of the correlations shifted direction in comparisons between high and low cortisol variabilities, suggesting a change of relationships. Clearly, however, low cortisol variability shows stronger associations than high variability with anthropometric, endocrine, metabolic, and hemodynamic parameters.
The endocrine associations deserve attention. Without weighting for diurnal cortisol secretion pattern, IGF-I, indicating GH secretion (30), showed a significant negative relationship, whereas associations with testosterone were not significant. With signs of normal HPA axis regulation (high variability), this shifted to a nonsignificant relationship with IGF-I. Finally, with a low variability in diurnal cortisol secretion, strong negative relationships were found with both testosterone and IGF-I. These shifts in associations with the status of the HPA axis suggest the following interpretation. With normal HPA axis status, perceived stress might be followed by elevation of testosterone values, whereas with signs of a perturbed HPA axis, regulation of both GH and testosterone secretion is severely inhibited. This has been found to follow chronic HPA axis activation (25). Statistical path-analytic models as well as subgrouping of the material according to endocrine status suggest that poor regulation of the HPA axis is followed by decreased testosterone and IGF-I values (Rosmond R., and P. Björntorp, to be published), giving support to the interpretation that HPA axis perturbations are followed by decreased testosterone and GH secretion (25).
Other statistical findings in this report might be possible to interpret mechanistically. Increased HPA axis activity is followed by visceral fat accumulation, as seen dramatically in Cushing’s syndrome (31); events at the adipocyte level have been at least partly elucidated (7). This might also be a consequence of low testosterone and GH secretion, with or without HPA axis dysregulation (7). Furthermore, the endocrine perturbations might cause or amplify insulin resistance (6). There is evidence that insulin resistance might be followed by both dyslipidemia and elevated blood pressure (32). This chain of events suggests a central role of perturbations in the HPA axis in the development of a number of complications. An activation of the central sympathetic nervous system may also be involved, because the central regulation of this system and that of the HPA axis are tightly coupled (25). Such involvement is suggested by the positive relationships between HPA axis activity and blood pressure as well as heart rate.
Although we are aware that statistical associations do not give information about causality, the observations summarized above strongly suggest that cortisol secretion as a response to perceived stress is a powerful factor regulating disease-generating events in the periphery. This seems to be particularly the case when the HPA axis functions with low reactivity and poor feedback control. This indicates that it is necessary to follow the acute reactions of the HPA axis following perceived stress to detect the associations reported in this work.
The condition of abdominal obesity with disturbed HPA axis described here and previously (6, 7) shows similarities with Cushing’s syndrome. Both are characterized by a perturbed HPA axis status, centralization of body fat, and abnormal endocrine, metabolic, and hemodynamic features. Abdominal obesity might be considered as a functional Cushing’s syndrome. The prevalence of the classical Cushing’s syndrome in the population studied was extremely low, and subjects with Cushing’s syndrome would have been revealed by failure to suppress endogenous cortisol secretion normally when dexamethasone was administered. It is, therefore, highly unlikely that the presence of Cushing’s syndrome among the men studied (n = 284) would occur and thereby distort the results.
Socio-economic handicaps, repeatedly described in subjects with abdominal obesity (8, 9, 10, 11, 12), provide an environment in which stress reactions would be expected to be frequent. Via adaptations of the regulatory systems of the HPA axis, this seems then to be followed by risk factors for prevalent disease. The results presented here might elucidate the long sought mechanism by which psychological and socio-economic factors influence somatic disease, particularly since these factors are also involved in the population studied here (11, 12).
It is hoped that the new methodology developed and reported here will provide better possibilities to examine putative pathogenetic factors causing the perturbations of HPA axis regulation associated with such risk factors.
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Acknowledgments |
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Footnotes |
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Received January 7, 1998.
Revised February 12, 1998.
Accepted February 19, 1998.
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References |
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M. Berthiaume, M. Laplante, W. T. Festuccia, K. Cianflone, L. P. Turcotte, D. R. Joanisse, G. Olivecrona, R. Thieringer, and Y. Deshaies 11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1045 - E1052. [Abstract] [Full Text] [PDF]
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C. M. Jewell and J. A. Cidlowski Molecular Evidence for a Link between the N363S Glucocorticoid Receptor Polymorphism and Altered Gene Expression J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3268 - 3277. [Abstract] [Full Text] [PDF]
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F. Dadoun, P. Darmon, V. Achard, S. Boullu-Ciocca, F. Philip-Joet, M. C. Alessi, M. Rey, M. Grino, and A. Dutour Effect of sleep apnea syndrome on the circadian profile of cortisol in obese men Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E466 - E474. [Abstract] [Full Text] [PDF]
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 M. Manco, J. M. Fernandez-Real, M. E. Valera-Mora, H. Dechaud, G. Nanni, V. Tondolo, M. Calvani, M. Castagneto, M. Pugeat, and G. Mingrone Massive Weight Loss Decreases Corticosteroid-Binding Globulin Levels and Increases Free Cortisol in Healthy Obese Patients: An adaptive phenomenon? Diabetes Care, June 1, 2007; 30(6): 1494 - 1500. [Abstract] [Full Text] [PDF]
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J. Buren, S.-A. Bergstrom, E. Loh, I. Soderstrom, T. Olsson, and C. Mattsson Hippocampal 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Messenger Ribonucleic Acid Expression Has a Diurnal Variability that Is Lost in the Obese Zucker Rat Endocrinology, June 1, 2007; 148(6): 2716 - 2722. [Abstract] [Full Text] [PDF]
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J. Holt-Lunstad and P. R. Steffen Diurnal Cortisol Variation is Associated With Nocturnal Blood Pressure Dipping Psychosom Med, May 1, 2007; 69(4): 339 - 343. [Abstract] [Full Text] [PDF]
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M. Klose, M. Lange, A. K. Rasmussen, N. E. Skakkebaek, L. Hilsted, E. Haug, M. Andersen, and U. Feldt-Rasmussen Factors Influencing the Adrenocorticotropin Test: Role of Contemporary Cortisol Assays, Body Composition, and Oral Contraceptive Agents J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1326 - 1333. [Abstract] [Full Text] [PDF]
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D. Qi and B. Rodrigues Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E654 - E667. [Abstract] [Full Text] [PDF]
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P. Darmon, F. Dadoun, S. Boullu-Ciocca, M. Grino, M.-C. Alessi, and A. Dutour Insulin resistance induced by hydrocortisone is increased in patients with abdominal obesity Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E995 - E1002. [Abstract] [Full Text] [PDF]
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D. Qi, D. An, G. Kewalramani, Y. Qi, T. Pulinilkunnil, A. Abrahani, U. Al-Atar, S. Ghosh, R. B. Wambolt, M. F. Allard, et al. Altered cardiac fatty acid composition and utilization following dexamethasone-induced insulin resistance Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E420 - E427. [Abstract] [Full Text] [PDF]
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B. Laferrere, C. Abraham, M. Awad, S. Jean-Baptiste, A. B. Hart, P. Garcia-Lorda, P. Kokkoris, and C. D. Russell Inhibiting Endogenous Cortisol Blunts the Meal-Entrained Rise in Serum Leptin J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2232 - 2238. [Abstract] [Full Text] [PDF]
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M. T. Foster, M. B. Solomon, K. L. Huhman, and T. J. Bartness Social defeat increases food intake, body mass, and adiposity in Syrian hamsters Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1284 - R1293. [Abstract] [Full Text] [PDF]
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S. K. Paulsen, S. B. Pedersen, J. O. L. Jorgensen, S. Fisker, J. S. Christiansen, A. Flyvbjerg, and B. Richelsen Growth Hormone (GH) Substitution in GH-Deficient Patients Inhibits 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Messenger Ribonucleic Acid Expression in Adipose Tissue J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1093 - 1098. [Abstract] [Full Text] [PDF]
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K. M Oltmanns, B. Dodt, B. Schultes, H. H Raspe, U. Schweiger, J. Born, H. L Fehm, and A. Peters Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients Eur. J. Endocrinol., February 1, 2006; 154(2): 325 - 331. [Abstract] [Full Text] [PDF]
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M. Grino Prenatal nutritional programming of central obesity and the metabolic syndrome: role of adipose tissue glucocorticoid metabolism Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1233 - R1235. [Full Text] [PDF]
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 R. C. Thurston, L. D. Kubzansky, I. Kawachi, and L. F. Berkman Is the Association between Socioeconomic Position and Coronary Heart Disease Stronger in Women than in Men? Am. J. Epidemiol., July 1, 2005; 162(1): 57 - 65. [Abstract] [Full Text] [PDF]
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D. J. Brotman, J. P. Girod, M. J. Garcia, J. V. Patel, M. Gupta, A. Posch, S. Saunders, G. Y. H. Lip, S. Worley, and S. Reddy Effects of Short-Term Glucocorticoids on Cardiovascular Biomarkers J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3202 - 3208. [Abstract] [Full Text] [PDF]
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 Academy of Psychosomatic Medicine: Proceedings From the 51st Annual Meeting: November 18-21, 2004, Marco Island, Florida Psychosomatics, April 1, 2005; 46(2): 153 - 186. [Full Text] [PDF]
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R. M Reynolds, B. R Walker, H. E Syddall, R. Andrew, P. J Wood, and D. I W Phillips Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity? Eur. J. Endocrinol., February 1, 2005; 152(2): 249 - 253. [Abstract] [Full Text] [PDF]
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A. J. Drake, D. E. W. Livingstone, R. Andrew, J. R. Seckl, N. M. Morton, and B. R. Walker Reduced Adipose Glucocorticoid Reactivation and Increased Hepatic Glucocorticoid Clearance as an Early Adaptation to High-Fat Feeding in Wistar Rats Endocrinology, February 1, 2005; 146(2): 913 - 919. [Abstract] [Full Text] [PDF]
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S. Boullu-Ciocca, A. Dutour, V. Guillaume, V. Achard, C. Oliver, and M. Grino Postnatal Diet-Induced Obesity in Rats Upregulates Systemic and Adipose Tissue Glucocorticoid Metabolism During Development and in Adulthood: Its Relationship With the Metabolic Syndrome Diabetes, January 1, 2005; 54(1): 197 - 203. [Abstract] [Full Text] [PDF]
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P. Kok, S. W. Kok, M. M. Buijs, J. J. M. Westenberg, F. Roelfsema, M. Frolich, M. P. M. Stokkel, A. E. Meinders, and H. Pijl Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment Am J Physiol Endocrinol Metab, November 1, 2004; 287(5): E848 - E856. [Abstract] [Full Text] [PDF]
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 P C Souverein, A Berard, T P Van Staa, C Cooper, A C G Egberts, H G M Leufkens, and B R Walker Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study Heart, August 1, 2004; 90(8): 859 - 865. [Abstract] [Full Text] [PDF]
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 O. Ousova, V. Guyonnet-Duperat, N. Iannuccelli, J.-P. Bidanel, D. Milan, C. Genet, B. Llamas, M. Yerle, J. Gellin, P. Chardon, et al. Corticosteroid Binding Globulin: A New Target for Cortisol-Driven Obesity Mol. Endocrinol., July 1, 2004; 18(7): 1687 - 1696. [Abstract] [Full Text] [PDF]
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D. Qi, T. Pulinilkunnil, D. An, S. Ghosh, A. Abrahani, J. A. Pospisilik, R. Brownsey, R. Wambolt, M. Allard, and B. Rodrigues Single-Dose Dexamethasone Induces Whole-Body Insulin Resistance and Alters Both Cardiac Fatty Acid and Carbohydrate Metabolism Diabetes, July 1, 2004; 53(7): 1790 - 1797. [Abstract] [Full Text] [PDF]
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N. M. Morton, L. Ramage, and J. R. Seckl Down-Regulation of Adipose 11{beta}-Hydroxysteroid Dehydrogenase Type 1 by High-Fat Feeding in Mice: A Potential Adaptive Mechanism Counteracting Metabolic Disease Endocrinology, June 1, 2004; 145(6): 2707 - 2712. [Abstract] [Full Text] [PDF]
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 K. M. Oltmanns, H. Gehring, S. Rudolf, B. Schultes, S. Rook, U. Schweiger, J. Born, H. L. Fehm, and A. Peters Hypoxia Causes Glucose Intolerance in Humans Am. J. Respir. Crit. Care Med., June 1, 2004; 169(11): 1231 - 1237. [Abstract] [Full Text] [PDF]
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N. M. Morton, J. M. Paterson, H. Masuzaki, M. C. Holmes, B. Staels, C. Fievet, B. R. Walker, J. S. Flier, J. J. Mullins, and J. R. Seckl Novel Adipose Tissue-Mediated Resistance to Diet-Induced Visceral Obesity in 11{beta}-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice Diabetes, April 1, 2004; 53(4): 931 - 938. [Abstract] [Full Text] [PDF]
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 E. F.C. van Rossum and S. W.J. Lamberts Polymorphisms in the Glucocorticoid Receptor Gene and Their Associations with Metabolic Parameters and Body Composition Recent Prog. Horm. Res., January 1, 2004; 59(1): 333 - 357. [Abstract] [Full Text]
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J. R. Seckl, N. M. Morton, K. E. Chapman, and B. R. Walker Glucocorticoids and 11beta-Hydroxysteroid Dehydrogenase in Adipose Tissue Recent Prog. Horm. Res., January 1, 2004; 59(1): 359 - 393. [Abstract] [Full Text]
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 M. Ehrhart-Bornstein, V. Lamounier-Zepter, A. Schraven, J. Langenbach, H. S. Willenberg, A. Barthel, H. Hauner, S. M. McCann, W. A. Scherbaum, and S. R. Bornstein Human adipocytes secrete mineralocorticoid-releasing factors PNAS, November 25, 2003; 100(24): 14211 - 14216. [Abstract] [Full Text] [PDF]
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J. Axelsson, T. Akerstedt, G. Kecklund, A. Lindqvist, and R. Attefors Hormonal changes in satisfied and dissatisfied shift workers across a shift cycle J Appl Physiol, November 1, 2003; 95(5): 2099 - 2105. [Abstract] [Full Text] [PDF]
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C. Mattsson, M. Lai, J. Noble, E. McKinney, J. L. Yau, J. R. Seckl, and B. R. Walker Obese Zucker Rats Have Reduced Mineralocorticoid Receptor and 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Expression in Hippocampus--Implications for Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in Obesity Endocrinology, July 1, 2003; 144(7): 2997 - 3003. [Abstract] [Full Text] [PDF]
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R. S. Lindsay, D. J. Wake, S. Nair, J. Bunt, D. E. W. Livingstone, P. A. Permana, P. A. Tataranni, and B. R. Walker Subcutaneous Adipose 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Activity and Messenger Ribonucleic Acid Levels Are Associated with Adiposity and Insulinemia in Pima Indians and Caucasians J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2738 - 2744. [Abstract] [Full Text] [PDF]
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Y. Liu, Y. Nakagawa, Y. Wang, R. Li, X. Li, T. Ohzeki, and T. C. Friedman Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice Diabetes, June 1, 2003; 52(6): 1409 - 1416. [Abstract] [Full Text] [PDF]
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 J.G. Dolfing, K.E. Tucker, C.M. Lem, J. Uittenbogaart, J.C. Verzijl, and D.H. Schweitzer Low 11-deoxycortisol to cortisol conversion reflects extra-adrenal factors in the majority of women with normo-gonadotrophic normo-estrogenic infertility Hum. Reprod., February 1, 2003; 18(2): 333 - 337. [Abstract] [Full Text] [PDF]
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R. C. Andrews, O. Herlihy, D. E. W. Livingstone, R. Andrew, and B. R. Walker Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5587 - 5593. [Abstract] [Full Text] [PDF]
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J.-M. Fernandez-Real, M. Pugeat, M. Grasa, M. Broch, J. Vendrell, J. Brun, and W. Ricart Serum Corticosteroid-Binding Globulin Concentration and Insulin Resistance Syndrome: A Population Study J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4686 - 4690. [Abstract] [Full Text] [PDF]
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V. Vicennati, L. Ceroni, L. Gagliardi, A. Gambineri, and R. Pasquali Response of the Hypothalamic-Pituitary-Adrenocortical Axis to High-Protein/Fat and High-Carbohydrate Meals in Women with Different Obesity Phenotypes J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3984 - 3988. [Abstract] [Full Text] [PDF]
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E. Rask, B. R. Walker, S. Soderberg, D. E. W. Livingstone, M. Eliasson, O. Johnson, R. Andrew, and T. Olsson Tissue-Specific Changes in Peripheral Cortisol Metabolism in Obese Women: Increased Adipose 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Activity J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3330 - 3336. [Abstract] [Full Text] [PDF]
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M. S. M. IP, B. LAM, M. M. T. NG, W. K. LAM, K. W. T. TSANG, and K. S. L. LAM Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 670 - 676. [Abstract] [Full Text] [PDF]
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R. Pasquali, B. Ambrosi, D. Armanini, F. Cavagnini, E. D. Uberti, G. Del Rio, G. de Pergola, M. Maccario, F. Mantero, M. Marugo, et al. Cortisol and ACTH Response to Oral Dexamethasone in Obesity and Effects of Sex, Body Fat Distribution, and Dexamethasone Concentrations: A Dose-Response Study J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 166 - 175. [Abstract] [Full Text] [PDF]
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K. M. Oltmanns, B. Fruehwald-Schultes, W. Kern, J. Born, H. L. Fehm, and A. Peters Hypoglycemia, But Not Insulin, Acutely Decreases LH and T Secretion in Men J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4913 - 4919. [Abstract] [Full Text] [PDF]
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D. S. Jessop, M. F. Dallman, D. Fleming, and S. L. Lightman Resistance to Glucocorticoid Feedback in Obesity J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4109 - 4114. [Abstract] [Full Text] [PDF]
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A. N. Vgontzas, E. O. Bixler, H.-M. Lin, P. Prolo, G. Mastorakos, A. Vela-Bueno, A. Kales, and G. P. Chrousos Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3787 - 3794. [Abstract] [Full Text] [PDF]
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C. Nilsson, B.-M. Larsson, E. Jennische, E. Eriksson, P. Bjorntorp, D. A. York, and A. Holmang Maternal Endotoxemia Results in Obesity and Insulin Resistance in Adult Male Offspring Endocrinology, June 1, 2001; 142(6): 2622 - 2630. [Abstract] [Full Text] [PDF]
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R. Rosmond, M. Chagnon, C. Bouchard, and P. Björntorp G-308A Polymorphism of the Tumor Necrosis Factor {{alpha}} Gene Promoter and Salivary Cortisol Secretion J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 2178 - 2180. [Abstract] [Full Text]
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M. G. Dobson, C. P. F. Redfern, N. Unwin, and J. U. Weaver The N363S Polymorphism of the Glucocorticoid Receptor: Potential Contribution to Central Obesity in Men and Lack of Association with Other Risk Factors for Coronary Heart Disease and Diabetes Mellitus J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 2270 - 2274. [Abstract] [Full Text]
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R. M. Reynolds, B. R. Walker, H. E. Syddall, C. B. Whorwood, P. J. Wood, and D. I. W. Phillips Elevated Plasma Cortisol in Glucose-Intolerant Men: Differences in Responses to Glucose and Habituation to Venepuncture J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1149 - 1153. [Abstract] [Full Text]
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R. M. Reynolds, B. R. Walker, H. E. Syddall, R. Andrew, P. J. Wood, C. B. Whorwood, and D. I. W. Phillips Altered Control of Cortisol Secretion in Adult Men with Low Birth Weight and Cardiovascular Risk Factors J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 245 - 250. [Abstract] [Full Text]
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 A. W. Hsing, J. Deng, I. A. Sesterhenn, F. K. Mostofi, F. Z. Stanczyk, J. Benichou, T. Xie, and Y.-T. Gao Body Size and Prostate Cancer: A Population-based Case-Control Study in China Cancer Epidemiol. Biomarkers Prev., December 1, 2000; 9(12): 1335 - 1341. [Abstract] [Full Text]
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V. Vicennati and R. Pasquali Abnormalities of the Hypothalamic-Pituitary-Adrenal Axis in Nondepressed Women with Abdominal Obesity and Relations with Insulin Resistance: Evidence for a Central and a Peripheral Alteration J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4093 - 4098. [Abstract] [Full Text]
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B. E. Levin, D. Richard, C. Michel, and R. Servatius Differential stress responsivity in diet-induced obese and resistant rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1357 - R1364. [Abstract] [Full Text] [PDF]
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A. M. Magarinos and B. S. McEwen Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress PNAS, September 26, 2000; 97(20): 11056 - 11061. [Abstract] [Full Text] [PDF]
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R. Rosmond, Y. C. Chagnon, G. Holm, M. Chagnon, L. Pérusse, K. Lindell, B. Carlsson, C. Bouchard, and P. Björntorp Hypertension in Obesity and the Leptin Receptor Gene Locus J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3126 - 3131. [Abstract] [Full Text]
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A. Johansson, K. Carlström, B. Ahrén, K. Cederquist, E. Krylborg, H. Forsberg, and T. Olsson Abnormal Cytokine and Adrenocortical Hormone Regulation in Myotonic Dystrophy J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3169 - 3176. [Abstract] [Full Text]
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 S. E. Sephton, R. M. Sapolsky, H. C. Kraemer, and D. Spiegel Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival J Natl Cancer Inst, June 21, 2000; 92(12): 994 - 1000. [Abstract] [Full Text] [PDF]
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 D. I. W. Phillips, B. R. Walker, R. M. Reynolds, D. E. H. Flanagan, P. J. Wood, C. Osmond, D. J. P. Barker, and C. B. Whorwood Low Birth Weight Predicts Elevated Plasma Cortisol Concentrations in Adults From 3 Populations Hypertension, June 1, 2000; 35(6): 1301 - 1306. [Abstract] [Full Text] [PDF]
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J. M. Turner-Cobb, S. E. Sephton, C. Koopman, J. Blake-Mortimer, and D. Spiegel Social Support and Salivary Cortisol in Women With Metastatic Breast Cancer Psychosom Med, May 1, 2000; 62(3): 337 - 345. [Abstract] [Full Text] [PDF]
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A. N. Vgontzas, D. A. Papanicolaou, E. O. Bixler, K. Hopper, A. Lotsikas, H.-M. Lin, A. Kales, and G. P. Chrousos Sleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1151 - 1158. [Abstract] [Full Text]
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A. Steptoe, M. Cropley, J. Griffith, and C. Kirschbaum Job Strain and Anger Expression Predict Early Morning Elevations in Salivary Cortisol Psychosom Med, March 1, 2000; 62(2): 286 - 292. [Abstract] [Full Text] [PDF]
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D. E. W. Livingstone, G. C. Jones, K. Smith, P. M. Jamieson, R. Andrew, C. J. Kenyon, and B. R. Walker Understanding the Role of Glucocorticoids in Obesity: Tissue-Specific Alterations of Corticosterone Metabolism in Obese Zucker Rats Endocrinology, February 1, 2000; 141(2): 560 - 563. [Abstract] [Full Text] [PDF]
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A. Emptoz-Bonneton, P. Cousin, K. Seguchi, G. V. Avvakumov, C. Bully, G. L. Hammond, and M. Pugeat Novel Human Corticosteroid-Binding Globulin Variant with Low Cortisol-Binding Affinity J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 361 - 367. [Abstract] [Full Text]
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G. C. Inglis, M. C. Ingram, C. D. Holloway, L. Swan, D. Birnie, W. S. Hillis, E. Davies, R. Fraser, and J. M. C. Connell Familial Pattern of Corticosteroids and Their Metabolism in Adult Human Subjects - the Scottish Adult Twin Study J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4132 - 4137. [Abstract] [Full Text]
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J. M. Solano and L. Jacobson Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA Am J Physiol Endocrinol Metab, October 1, 1999; 277(4): E708 - E716. [Abstract] [Full Text] [PDF]
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L. Plat, R. Leproult, M. L’Hermite-Baleriaux, F. Fery, J. Mockel, K. S. Polonsky, and E. Van Cauter Metabolic Effects of Short-Term Elevations of Plasma Cortisol Are More Pronounced in the Evening Than in the Morning J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3082 - 3092. [Abstract] [Full Text]
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J. A. Yanovski, K. D. Miller, T. Kino, T. C. Friedman, G. P. Chrousos, C. Tsigos, and J. Falloon Endocrine and Metabolic Evaluation of Human Immunodeficiency Virus-Infected Patients with Evidence of Protease Inhibitor-Associated Lipodystrophy J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1925 - 1931. [Abstract] [Full Text]
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i), between stress-related cortisol secretion
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