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Submitted on April 2, 2004
Accepted on October 5, 2004
Department of Molecular & Clinical Endocrinology and Oncology (F.O.Jr, T.C., L.T., S.S., A.C., G.L.) University "Federico II" Naples, Italy; Department of Obstetrics and Gynecology (S.P., T.R., F.Z.), University "Magna Graecia" of Catanzaro, Italy; "MeriGen" Laboratory of Molecular Biology (S.D.B., D.L.), Naples, Italy; Department of Clinical and Experimental Medicine, Gastroenterology Unit, "Federico II" University (F.M.), Naples, Italy; Department of Obstetrics and Gynaecology (L.G.N.), Kingston Hospital, Surrey, United Kingdom
* To whom correspondence should be addressed.
FRANCESCO ORIO Jr, E-mail: francescoorio{at}virgilio.it
White blood cell (WBC) count is a known risk factor for atherosclerotic vascular disease in adult women. Polycystic ovary syndrome (PCOS) is potentially a risk factor for atherosclerosis and cardiovascular disease. The aim of the present study was to investigate leukocyte count in PCOS. One hundred and fifty PCOS women matched for age and body mass index (BMI) with one hundred and fifty healthy women were enrolled. WBC count, C-reactive protein (CRP) and a complete anthropometrical, metabolic and hormonal evaluation was performed in both groups. Serum insulin, glucose levels and lipid profile were also measured in each subject. WBC count was significantly higher (P < 0.0001) in PCOS: 7260 (393), cell/mm3 (IQR) compared with controls: 5220 (210), cell/mm3 (IQR). CRP levels were significantly increased (P < 0.0001) in PCOS: 2 (1) mg/L (IQR) compared with healthy women: 0.7 (0.8), mg/L (IQR). In both groups, there was a significant (P < 0.0001) linear correlation between WBC count and HOMA score (PCOS: r=0.94, Controls: r=0.91). Multiple linear regression analysis showed that other hormone levels are not predictors of leukocyte count both in PCOS and control women. In conclusion, our data demonstrate that PCOS women have an increased WBC count which correlate with HOMA values.
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