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Submitted on July 14, 2004
Accepted on November 10, 2004
Division of Endocrinology, Tufts-New England Medical Center, Boston, MA, USA; Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA USA; Biostatistics Department, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
* To whom correspondence should be addressed.
Bess Dawson-Hughes, E-mail: Bess.Dawson-Hughes{at}Tufts.edu
This study was conducted to examine the effect of calcium intake on the rise in serum 25-hydroxyvitamin D [25(OH)D] levels in response to supplemental vitamin D3. Fifty-two healthy older men and women were randomly assigned to take calcium (500 mg twice daily with meals) or placebo tablets for 90 days between October first and the end of March. All participants were placed on 800 IU/day (20 µg/day) of vitamin D3. Serum 25(OH)D measurements were made at baseline and on days 30, 60 and 90. The mean baseline 25(OH)D values were 19.2 ± 6.4 ng/ml (47.9 ± 15.9 nmol/L) in the calcium group and 19.6 ± 6.7 ng/ml (49.1 ± 16.7 nmol/L) in the control group (P = 0.808). The difference in pattern of change in 25(OH)D was not statistically significant (group by time interaction P = 0.651); the calcium group increased 6.5 ± 5.9 ng/ml (16.2 ± 14.8 nmol/L)(P < 0.001) and the control group 6.6 ± 7.0 ng/ml (16.6 ± 17.4 nmol/L) (P < 0.001). The 95% CI for difference in mean increase, calcium-control, was -3.8 ± 3.5 ng/ml (-9.6, 8.7) nmol/L. In older men and women, the level of calcium intake, within the range of 500 - 1500 mg/day, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 µg)/day of vitamin D3.
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