| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
Submitted on November 12, 2004
Accepted on January 21, 2005
Medical Chronobiology Program, Brigham & Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
* To whom correspondence should be addressed. E-mail: cmantzor{at}bidmc.harvard.edu.
Leptin and adiponectin play important physiological roles in regulating appetite, food intake and energy balance, and have pathophysiological roles in obesity and anorexia nervosa. To assess the relative contributions of day/night patterns in behaviors (sleep/wake cycle and food intake) and of the endogenous circadian pacemaker on observed day/night patterns of adipokines, in 6 healthy subjects we measured circulating leptin, soluble leptin receptor, adiponectin, glucose and insulin adipokine levels throughout a ‘constant routine' protocol (38 h of wakefulness with constant posture, temperature, and dim light, as well as identical snacks every 2 h), and throughout sleep and fasting periods before and after the constant routine. There were significant endogenous circadian rhythms in leptin, glucose and insulin, with peaks around the usual time of awakening. Sleep/fasting resulted in additional systematic decreases in leptin, glucose and insulin, whereas wakefulness/food intake resulted in a systematic increase in leptin. Thus, the day/night pattern in leptin is likely caused by combined effects from the endogenous circadian pacemaker and day/night patterns in behaviors. Our data imply that alterations in the sleep/wake schedule would lead to an increased daily range in circulating leptin, with lowest leptin upon awakening, which, by influencing food intake and energy balance, could be implicated in the increased prevalence of obesity in the shift work population.
This article has been cited by other articles:
 |
|
 |
|
  A. V Nedeltcheva, J. M Kilkus, J. Imperial, K. Kasza, D. A Schoeller, and P. D Penev Sleep curtailment is accompanied by increased intake of calories from snacks Am. J. Clinical Nutrition, January 1, 2009; 89(1): 126 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. E. Blumer, S. N. van der Crabben, M. E. Stegenga, M. W. Tanck, M. T. Ackermans, E. Endert, T. van der Poll, and H. P. Sauerwein Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E613 - E617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Lumeng, D. Somashekar, D. Appugliese, N. Kaciroti, R. F. Corwyn, and R. H. Bradley Shorter Sleep Duration Is Associated With Increased Risk for Being Overweight at Ages 9 to 12 Years Pediatrics, November 1, 2007; 120(5): 1020 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Laughlin, E. Barrett-Connor, S. May, and C. Langenberg Association of Adiponectin with Coronary Heart Disease and Mortality: The Rancho Bernardo Study Am. J. Epidemiol., January 15, 2007; 165(2): 164 - 174. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
