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This version published online on August 9, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-0261
A more recent version of this article appeared on November 1, 2005
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Submitted on February 7, 2005
Accepted on August 2, 2005

Leptin and Adiponectin Responses in Overweight Inactive Elderly Following Resistance Training and Detraining are Intensity-Related

I. G. Fatouros*, S. Tournis, D. Leontsini, A. Z Jamurtas, M. Sxina, P. Thomakos, M. Manousaki, I. Douroudos, K. Taxildaris, and A. Mitrakou

Department of Physical Education and Sports Science, Democritus University of Thrace, Komotini 69100 Greece; Diabetes and Metabolism Unit, Henry Dunant Hospital, Athens, Greece; Department of Physical Education & Sports Sciences, University of Thessaly, Trikala 42100, Greece; Department of Pediatrics, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, 68100, Greece; Department of Biochemistry, Henry Dunant Hospital, Athens, Greece

* To whom correspondence should be addressed. E-mail: fatouros{at}otenet.gr.

Context. Adiponectin and leptin are closely related to weight control and energy balance whereas exercise affects elderly metabolic regulation and functional capacity. Objective. To investigate leptin and adiponectin responses in elderly males following exercise training and detraining. Design. One-year randomized controlled trial. Setting. Laboratory of Physical Education & Sport Science Department. Participants. Fifty inactive men (65-78 yr, BMI 28.7-30.2 kg/m2) recruited from a volunteer database, by word of mouth and fliers sent to medical practitioners, physiotherapists and nursing homes in the local community. Intervention(s). Participants were randomly assigned to a control (C, n = 10), low-intensity (LI/n = 14), moderate-intensity (MI/n = 12), and high-intensity training (HI/n = 14) group. Resistance training (6-months, 3-day/week, 10 exercises/3 sets) was followed by 6-month detraining. Main Outcome Measure(s). Strength, exercise energy cost (EEC), skinfold sum, body weight, VO2max, resting metabolic rate (RMR), plasma leptin and adiponectin were determined at baseline, and following training and detraining. Results. Strength, VO2max, RMR, EEC increased (P < 0.05) post-training in an intensity-dependent manner. Skinfold-sum and BMI were reduced by resistance training (P < 0.05) with HI being more effective (P < 0.05) than MI/LI. Leptin was diminished (P < 0.05) by all treatments while adiponectin increased (P < 0.05) only in HI. Detraining maintained training-induced changes only in HI. Leptin % decrease was associated (P < 0.05) with BMI % decrease and RMR % increase while adiponectin % increase was associated (P < 0.05) with BMI % decrease. Conclusions. Resistance training and detraining may alter leptin and adiponectin responses in an intensity-dependent manner. Leptin and adiponectin changes were strongly associated with RMR and anthropometric changes.
Key words: Adipocytokines • Resistance Exercise • Elderly • Metabolic Rate




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