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Submitted on February 22, 2005
Accepted on July 29, 2005
Endocrinology, Diabetes and Hypertension Division, (O.G., S.H., U.C.N., G.H.W.), and the Division of Cardiology (T.S.P.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; and Cardiovascular Genetics, Cardiology Division, University of Utah(P.N.H.), and Department of Genetics and Clinical Investigation Centre (X.J.), APHP 9201, Hopital Europeen Georges Pompidou, Paris, France
* To whom correspondence should be addressed. E-mail: gwilliams{at}partners.org.
Background: Studies suggest that there are genetic variants that influence both blood pressure regulation and serum TSH levels. We investigated if high-normal TSH values aggregate in hypertensive families. The influence of hypertension family history on serum TSH levels in healthy normotensive individuals was also examined.
Methods: All subjects were euthyroid (TSH 0.5-5.0 mIU/L). 333 hypertensives, including 229 members of multiple sibling families had blood samples for serum TSH determination drawn in the morning after overnight bedrest. High-normal TSH was defined as values > 2.0 mIU/L and 
5.0 mIU/L. 31 healthy normotensives provided information about their family history of hypertension by telephone.
Results: The concordance for high-normal TSH values among hypertensive multiple sibling families was greater than expected by chance (P = 0.009). There were nearly twice as many families concordant for high-normal TSH status as expected (13.2% vs. 7.0%), while the observed proportion concordant for normal-TSH status was similar to that expected (58.3% vs. 54.1%). Family membership explained a significant proportion of variance in TSH status (P = 0.038). Healthy normotensives with family history of hypertension had significantly higher TSH values (2.2 ± 1.2 mIU/L) compared with those with negative family history of hypertension (TSH 1.3 ± 0.7 mIU/L) independent of other characteristics (P = 0.025).
Conclusions: There is familial aggregation of high-normal TSH values in hypertensive families and hypertension family history influences serum TSH levels in healthy individuals. These findings are consistent with the existence of genetic variants affecting both blood pressure regulation and serum TSH levels.
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