help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on May 31, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-0385
A more recent version of this article appeared on August 1, 2005
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
90/8/4452    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barrenäs, M.-L.
Right arrow Articles by Lundgren, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barrenäs, M.-L.
Right arrow Articles by Lundgren, M.

Submitted on February 22, 2005
Accepted on May 25, 2005

High risk of sensorineural hearing loss in men born small for gestational age with and without obesity or height catch-up growth -A prospective longitudinal register study on birth size in 245.000 Swedish conscripts

Marie-Louise Barrenäs associate professor of otorhinolaryngology*, Björn Jonsson PhD, Torsten Tuvemo professor of pediatrics, Per-Anders Hellström PhD, and Maria Lundgren MD, PhD

Göteborg Pediatric Growth Research Centre, Department of Pediatrics, Institute of the Health of Women and Children, Göteborg University, Göteborg, Sweden; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Swedish Armed Forces, Headquarters, Army Safety Inspectorate, Stockholm, Sweden

* To whom correspondence should be addressed. E-mail: marie-louise.barrenas{at}vgregion.se.

Background: Several components of the metabolic syndrome (MS) coincide with those risk factors linked to sensorineural hearing loss (SNHL). According to the "Thrifty Phenotype Hypothesis" (TPH) the MS can be caused by events during the fetal period. This study tests the TPH on hearing, using body size at birth and conscription as indirect markers for fetal programing and BMI as indicator for the MS.

Methods: Odds ratios were used to analyze birth data regarding body size from birth to conscription as risk factors for hearing loss in 245 092 conscripted Swedish men.

Findings: Compared with conscripts born short for gestational age (GA) with catch-up growth, those born short with absence of catch-up growth exhibited 134% higher risk of SNHL. Adult short stature was associated with a 50% increased risk. Compared with conscripts with average BMI, overweight was associated with 30%, obesity 99% and overweight if born light for GA 118% higher risk of SNHL. Conscripts born light for GA had a 41% increased risk, independent on later growth pattern.

Conclusion: The TPH seems valid also for SNHL, meaning that SNHL in adulthood may originate from events during fetal life. SNHL might be a new clinical feature of the metabolic syndrome.
Key words: hearing loss • deafness • short stature • obesity • metabolic syndrome




This article has been cited by other articles:


Home page
 PediatricsHome page
Joint Committee on Infant Hearing
Year 2007 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs
Pediatrics, October 1, 2007; 120(4): 898 - 921.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
Y. J. Cheng, E. W. Gregg, H. S. Kahn, D. E. Williams, N. De Rekeneire, and K. M. V. Narayan
Peripheral Insensate Neuropathy--A Tall Problem for US Adults?
Am. J. Epidemiol., November 1, 2006; 164(9): 873 - 880.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society