| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on December 22, 2006
Accepted on March 5, 2007
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, Harris Center, Massachusetts General Hospital, Boston, MA, Division of Adolescent Medicine, MassGeneral Hospital for Children and Harvard Medical School, Boston, MA, Division of Adolescent Medicine, Department of Paediatrics, Hospital for Sick Kids, Toronto, Canada
* To whom correspondence should be addressed. E-mail: mmisra{at}partners.org.
Background: Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Adipokines and insulin play an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown.
Objective: To determine whether adipokines and insulin are independently associated with measures of BMD in adolescents with AN and controls.
Design/Methods: Levels of adiponectin and insulin, fasting and after oral glucose, were evaluated in 17 AN and 19 controls 12-18 yo, in whom hormonal parameters (growth hormone, IGF-I, cortisol, estradiol, leptin, ghrelin and peptide YY) had been previously determined. Body composition, bone mineral content (BMC) and BMD at the lumbar spine (LS), hip, femoral neck (FN) and total body (TB) were assessed by DXA. Two bone formation and bone resorption markers were examined.
Setting: General Clinical Research Center.
Results: Adiponectin differed between AN and controls after controlling for fat mass, and decreased in both following oral glucose (P = 0.02 and 0.07). On regression modeling, independent associations were observed of (i) BMI and adiponectin with LS bone mineral apparent density (BMAD) Z- scores (r2 = 0.45), (ii) lean mass, peptide YY and ghrelin with hip Z-scores (r2 = 0.55), (iii) adiponectin and lean mass with FN-BMAD Z-scores (r2 = 0.34), and (iv) lean mass, PYY, GH and ghrelin with TB-BMC/height Z-scores (r2 = 0.64), for the combined group. Adiponectin was also independently associated with BMD, and insulin with bone turnover markers in the groups considered separately.
Conclusions: Adiponectin contributes significantly to the variability of bone density, and insulin to bone turnover markers in adolescent girls.
This article has been cited by other articles:
 |
|
 |
|
  M. A. Bredella, M. Misra, K. K. Miller, I. Madisch, A. Sarwar, A. Cheung, A. Klibanski, and R. Gupta Distal Radius in Adolescent Girls with Anorexia Nervosa: Trabecular Structure Analysis with High-Resolution Flat-Panel Volume CT Radiology, December 1, 2008; 249(3): 938 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Michaelsson, L. Lind, J. Frystyk, A. Flyvbjerg, R. Gedeborg, C. Berne, B. Zethelius, H. Mallmin, S. Soderberg, and H. Melhus Serum Adiponectin in Elderly Men Does Not Correlate with Fracture Risk J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 4041 - 4047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Misra, D. K. Katzman, J. Cord, S. J. Manning, N. Mendes, D. B. Herzog, K. K. Miller, and A. Klibanski Bone Metabolism in Adolescent Boys with Anorexia Nervosa J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3029 - 3036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Misra, R. Prabhakaran, K. K. Miller, M. A. Goldstein, D. Mickley, L. Clauss, P. Lockhart, J. Cord, D. B. Herzog, D. K. Katzman, et al. Prognostic Indicators of Changes in Bone Density Measures in Adolescent Girls with Anorexia Nervosa-II J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1292 - 1297. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
