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This version published online on November 6, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-0526
A more recent version of this article appeared on December 1, 2007
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Submitted on March 8, 2007
Accepted on October 29, 2007

The Somatomedin Hypothesis 2007: Fifty Years Later

Solomon A. Kaplan* and Pinchas Cohen

David Geffen School of Medicine at UCLA, Los Angeles, CA 90095

* To whom correspondence should be addressed. E-mail: skaplan{at}mednet.ucla.edu.

Context: The somatomedin/insulin-like growth factor (IGF) hypothesis was based on the observation that growth hormone (GH) was inactive when added to an in vitro incubation system but required a GH-dependent substance in the circulation to mediate its activity. Newer experimental evidence has led to several modifications of the hypothesis but none of the proposed modifications accounts for all of the integrated actions of GH and IGF-I. In this paper we propose an augmentative/counteractive modification of the existing hypothesis that takes into account all the actions of the GH-IGF system.

Evidence Acquisition: The modification is based on experimental evidence published since the hypothesis was originally developed.

Evidence Synthesis: The modification is based on an integration of the results of published experimental evidence regarding the actions of GH and the IGF complex.

Conclusion: We propose a new augmentative/counteractive modification of the hypothesis that the actions of the GH-IGF system provide a distinct evolutionary advantage to the organism by augmenting the anabolic actions of GH while countering its potentially deleterious effects of hyperglycemia and depletion of lipid stores.
Key words: somatotropin • IGF • somatomedin • growth




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