Context: Excess GH and IGF-I in acromegaly are associated with reduced life expectancy due to cardiovascular complications.

Objective: To investigate the prevalence, incidence and severity of cardiac valve regurgitation before and after somatostatin-analog treatment in acromegaly.

Design: Prospective, observer-blinded, multicenter, 12-month study.

Setting: 33 specialist centers.

Patients: 225 adult patients with acromegaly without significant cardiac valve abnormalities or prior valve-replacement surgery, matched for age, sex and center/country/study.

Interventions: Initiation/continuation of lanreotide (n = 107) or octreotide treatment (n = 118), tailored for optimal disease control.

Main outcome measures: Relative risk of new/worsening regurgitation in any valve at 12 months compared with baseline.

Results: At baseline, almost 80% of patients had some degree of cardiac valve regurgitation, although none was severe. The risk of developing new/worsening regurgitation in any valve at 12 months was non-significant and similar for the cohorts (adjusted odds ratio, 0.86; 95% CI: 0.41–1.82; P = 0.694; relative risk, 1.04; 95% CI: 0.67–1.60; risk difference, 0.01; 95% CI: –0.13–0.16). For 54% of patients, the severity of regurgitation stayed the same during the study. At baseline, ‘significant’ valve regurgitation occurred in 18% of patients (lanreotide cohort) and 13% (octreotide cohort), and at 12 months in 18% of each cohort.

Conclusions: The incidence of valve regurgitation did not change over 12 months' treatment with somatostatin analogs and most cases were physiologic or mild in severity. There was no significant difference between somatostatin analogs in the risk of developing new/worsening valve regurgitation or significant regurgitation after 1 yr.