help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on March 11, 2008
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-2383
A more recent version of this article appeared on June 1, 2008
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
93/6/2307    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Riedl, M.
Right arrow Articles by Luger, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Riedl, M.
Right arrow Articles by Luger, A.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Weight Loss Surgery
Related Collections
Right arrow Calcium and Bone Metabolism
Right arrow Diabetes and Insulin
Right arrow Metabolism
Right arrow Obesity

Submitted on October 25, 2007
Accepted on March 5, 2008

Plasma osteopontin increases after bariatric surgery and correlates with markers of bone turnover but not with insulin resistance

Michaela Riedl*, Greisa Vila, Christina Maier, Ammon Handisurya, Soheila Shakeri-Manesch, Gerhard Prager, Oswald Wagner, Alexandra Kautzky-Willer, Bernhard Ludvik, Martin Clodi, and Anton Luger

Division of Endocrinology and Metabolism, Department of Medicine III (M.R., G.V., C.M., A.H., A.K-W., B.L., M.C., A.L.), Division of General Surgery, Department of Surgery (S.S-M., G.P.) and Clinical Institute of Medical and Chemical Laboratory Diagnostics (O.W.), Medical University of Vienna, Vienna, Austria

* To whom correspondence should be addressed. E-mail: michaela.riedl{at}meduniwien.ac.at.

Context: Osteopontin (OPN) is a multifunctional protein involved in bone metabolism, cardiovascular disease, diabetes and obesity. OPN levels are elevated in the plasma and adipose tissue of obese subjects and are decreased with diet-induced weight loss.

Objective: We investigated the effect of bariatric surgery on plasma OPN concentrations in morbidly obese patients.

Setting: The study was performed at a University Hospital.

Subjects: We investigated 40 obese patients aged 43.1 ± 1.8 years, scheduled to undergo bariatric surgery. Roux-en-Y gastric bypass (RYGB) was performed in 30 subjects (27 females, 3 males), and laparoscopic adjustable gastric banding (LAGB) in 10 subjects (8 females, 2 males).

Study design: All patients were studied before and one year after (10.3 to 14.8 months) the intervention.

Main outcome measures: OPN, leptin, C-reactive protein (CRP), insulin, HOMA insulin resistance index, calcium, 25-hydroxyvitamin D, C-telopeptide, and osteocalcin (OC) were determined.

Results: Both bariatric procedures significantly reduced body weight, body mass index, insulin, leptin and CRP one year after surgery. Plasma OPN increased from 31.4 ± 3.8 to 52.8 ± 3.7 ng/ml after RYGB (P<0.001) and from 29.8 ± 6.9 to 46.4 ± 10.6 ng/ml after LAGB (P=0.042). Preoperative OPN correlated with age, insulin, HOMA insulin resistance index and postoperative OPN. Postoperative OPN correlated with C-telopeptide and OC.

Conclusions: One year after RYGB and LAGB, plasma OPN levels significantly increased and correlated with biomarkers of bone turnover. Unlike other proinflammatory cytokines, OPN does not normalize, but increases further after bariatric surgery.
Key words: osteopontin • obesity • bariatric surgery • insulin resistance • bone turnover






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2008 by The Endocrine Society