Articles listed in blue may be of special interest to clinicians.

Special Articles:

Wassim Y. Almawi, Hala Tamim, and Sami T. Azar

CLINICAL REVIEW 103:T Helper Type 1 and 2 Cytokines Mediate the Onset and Progression of Type I (Insulin-Dependent) Diabetes
J Clin Endocrinol Metab 1999 84: 1497-1502 doi:10.1210/jc.84.5.1497 [Abstract] [Full Text] [PDF]  

Allen W. Root

EDITORIAL:Neonatal Screening for 21-Hydroxylase Deficient Congenital Adrenal Hyperplasia—The Role of CYP21 Analysis
J Clin Endocrinol Metab 1999 84: 1503-1504 doi:10.1210/jc.84.5.1503 [Full Text] [PDF]  

Nicholas J. Sarlis, Stacie J. Weil, and Lawrence M. Nelson

CLINICAL CASE SEMINAR:Administration of Metformin to a Diabetic Woman with Extreme Hyperandrogenemia of Nontumoral Origin: Management of Infertility and Prevention of Inadvertent Masculinization of a Female Fetus
J Clin Endocrinol Metab 1999 84: 1510-1512 doi:10.1210/jc.84.5.1510 [Full Text] [PDF]  

S. R. Bornstein and G. P. Chrousos

CLINICAL REVIEW 104:Adrenocorticotropin (ACTH)- and Non-ACTH-Mediated Regulation of the Adrenal Cortex: Neural and Immune Inputs
J Clin Endocrinol Metab 1999 84: 1729-1736 doi:10.1210/jc.84.5.1729 [Full Text] [PDF]  

Original Studies:

Anna Nordenström, Astrid Thilén, Lars Hagenfeldt, Agne Larsson, and Anna Wedell

Genotyping Is a Valuable Diagnostic Complement to Neonatal Screening for Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency
J Clin Endocrinol Metab 1999 84: 1505-1509 doi:10.1210/jc.84.5.1505 [Abstract] [Full Text] [PDF]  

P. Marceau, S. Biron, F.-S. Hould, S. Marceau, S. Simard, S. N. Thung, and J. G. Kral

Liver Pathology and the Metabolic Syndrome X in Severe Obesity
J Clin Endocrinol Metab 1999 84: 1513-1517 doi:10.1210/jc.84.5.1513 [Abstract] [Full Text] [PDF]  

Annamaria Colao, Alberto Cuocolo, Paolo Marzullo, Emanuele Nicolai, Diego Ferone, Anna Maria Della Morte, Mario Petretta, Marco Salvatore, and Gaetano Lombardi

Impact of Patient’s Age and Disease Duration on Cardiac Performance in Acromegaly: A Radionuclide Angiography Study
J Clin Endocrinol Metab 1999 84: 1518-1523 doi:10.1210/jc.84.5.1518 [Abstract] [Full Text] [PDF]  

M. A. Flynn, D. Weaver-Osterholtz, K. L. Sharpe-Timms, S. Allen, and G. Krause

Dehydroepiandrosterone Replacement in Aging Humans
J Clin Endocrinol Metab 1999 84: 1527-1533 doi:10.1210/jc.84.5.1527 [Abstract] [Full Text] [PDF]  

Emad Sabbah, Kaisa Savola, Petri Kulmala, Riitta Veijola, Paula Vähäsalo, Jukka Karjalainen, Hans K. Åkerblom, and Mikael Knip

Diabetes-Associated Autoantibodies in Relation to Clinical Characteristics and Natural Course in Children with Newly Diagnosed Type 1 Diabetes
J Clin Endocrinol Metab 1999 84: 1534-1539 doi:10.1210/jc.84.5.1534 [Abstract] [Full Text] [PDF]  

Joel E. Michalek, Fatema Z. Akhtar, and Johnathan L. Kiel

Serum Dioxin, Insulin, Fasting Glucose, and Sex Hormone-Binding Globulin in Veterans of Operation Ranch Hand
J Clin Endocrinol Metab 1999 84: 1540-1543 doi:10.1210/jc.84.5.1540 [Abstract] [Full Text] [PDF]  

Enzo Bonora, Giovanni Targher, Maria Alberiche, Riccardo C. Bonadonna, Francesca Saggiani, Marina B. Zenere, Stefano Uleri, and Michele Muggeo

Effect of Chronic Treatment with Lacidipine or Lisinopril on Intracellular Partitioning of Glucose Metabolism in Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 1999 84: 1544-1550 doi:10.1210/jc.84.5.1544 [Abstract] [Full Text] [PDF]  

Bernd Fruehwald-Schultes, Werner Kern, Eva Deininger, Peter Wellhoener, Wolfgang Kerner, Jan Born, Horst L. Fehm, and Achim Peters

Protective Effect of Insulin against Hypoglycemia-Associated Counterregulatory Failure
J Clin Endocrinol Metab 1999 84: 1551-1557 doi:10.1210/jc.84.5.1551 [Abstract] [Full Text] [PDF]  

Francis de Zegher, Marc V. L. Du Caju, Claudine Heinrichs, Marc Maes, Jean De Schepper, Margareta Craen, Karin Vanweser, Paul Malvaux, and Ron G. Rosenfeld

Early, Discontinuous, High Dose Growth Hormone Treatment to Normalize Height and Weight of Short Children Born Small for Gestational Age: Results Over 6 Years
J Clin Endocrinol Metab 1999 84: 1558-1561 doi:10.1210/jc.84.5.1558 [Abstract] [Full Text] [PDF]  

D. W. Dempster, M. Parisien, S. J. Silverberg, X.-G. Liang, M. Schnitzer, V. Shen, E. Shane, D. B. Kimmel, R. Recker, R. Lindsay, and J. P. Bilezikian

On the Mechanism of Cancellous Bone Preservation in Postmenopausal Women with Mild Primary Hyperparathyroidism
J Clin Endocrinol Metab 1999 84: 1562-1566 doi:10.1210/jc.84.5.1562 [Abstract] [Full Text] [PDF]  

C. Dacou-Voutetakis and M. Dracopoulou

High Incidence of Molecular Defects of the CYP21 Gene in Patients with Premature Adrenarche
J Clin Endocrinol Metab 1999 84: 1570-1574 doi:10.1210/jc.84.5.1570 [Abstract] [Full Text] [PDF]  

Wen-Lieng Lee, Jaw-Wen Chen, Chih-Tai Ting, Shing-Jong Lin, and Ping H. Wang

Changes of the Insulin-Like Growth Factor I System during Acute Myocardial Infarction: Implications on Left Ventricular Remodeling
J Clin Endocrinol Metab 1999 84: 1575-1581 doi:10.1210/jc.84.5.1575 [Abstract] [Full Text] [PDF]  

J. Hangaard, M. Andersen, E. Grodum, O. Koldkjær, and C. Hagen

The Effects of Endogenous Opioids and Cortisol on Thyrotropin and Prolactin Secretion in Patients with Addison’s Disease
J Clin Endocrinol Metab 1999 84: 1595-1601 doi:10.1210/jc.84.5.1595 [Abstract] [Full Text] [PDF]  

Cecilia Camacho-Hübner, Katie A. Woods, Farideh Miraki-Moud, Peter C. Hindmarsh, Adrian J. Clark, Yngve Hansson, Atholl Johnston, Robert C. Baxter, and Martin O. Savage

Effects of Recombinant Human Insulin-Like Growth Factor I (IGF-I) Therapy on the Growth Hormone-IGF System of a Patient with a Partial IGF-I Gene Deletion
J Clin Endocrinol Metab 1999 84: 1611-1616 doi:10.1210/jc.84.5.1611 [Abstract] [Full Text] [PDF]  

Babek Imani, Marinus J. C. Eijkemans, Egbert R. te Velde, J. Dik F. Habbema, and Bart C. J. M. Fauser

Predictors of Chances to Conceive in Ovulatory Patients during Clomiphene Citrate Induction of Ovulation in Normogonadotropic Oligoamenorrheic Infertility
J Clin Endocrinol Metab 1999 84: 1617-1622 doi:10.1210/jc.84.5.1617 [Abstract] [Full Text] [PDF]  

Nobuyuki Shihara, Koichiro Yasuda, Toshio Moritani, Hidetoshi Ue, Tetsuya Adachi, Hisako Tanaka, Kinsuke Tsuda, and Yutaka Seino

The Association between Trp⁶⁴Arg Polymorphism of the ß₃-Adrenergic Receptor and Autonomic Nervous System Activity
J Clin Endocrinol Metab 1999 84: 1623-1627 doi:10.1210/jc.84.5.1623 [Abstract] [Full Text] [PDF]  

Eckhard Korsch, Michael Peter, Olaf Hiort, Wolfgang G. Sippell, Benno M. Ure, Berthold P. Hauffa, and Martin Bergmann

Gonadal Histology with Testicular Carcinoma in Situ in a 15-Year-Old 46,XY Female Patient with a Premature Termination in the Steroidogenic Acute Regulatory Protein Causing Congenital Lipoid Adrenal Hyperplasia
J Clin Endocrinol Metab 1999 84: 1628-1632 doi:10.1210/jc.84.5.1628 [Abstract] [Full Text] [PDF]  

Yoshiyu Takeda, Kenji Furukawa, Satoru Inaba, Isamu Miyamori, and Hiroshi Mabuchi

Genetic Analysis of Aldosterone Synthase in Patients with Idiopathic Hyperaldosteronism
J Clin Endocrinol Metab 1999 84: 1633-1637 doi:10.1210/jc.84.5.1633 [Abstract] [Full Text] [PDF]  

Stephanie R. Edmondson, Vincenzo C. Russo, Andrew C. McFarlane, Christopher J. Wraight, and George A. Werther

Interactions between Growth Hormone, Insulin-Like Growth Factor I, and Basic Fibroblast Growth Factor in Melanocyte Growth
J Clin Endocrinol Metab 1999 84: 1638-1644 doi:10.1210/jc.84.5.1638 [Abstract] [Full Text] [PDF]  

Johnny Deladoëy, Christa Flück, Atilla Büyükgebiz, Beatrice V. Kuhlmann, Andrée Eblé, Peter C. Hindmarsh, Wei Wu, and Primus E. Mullis

"Hot Spot" in the PROP1 Gene Responsible for Combined Pituitary Hormone Deficiency
J Clin Endocrinol Metab 1999 84: 1645-1650 doi:10.1210/jc.84.5.1645 [Abstract] [Full Text] [PDF]  

Juan Carlos Jaume, Jin Guo, Yan Wang, Basil Rapoport, and Sandra M. McLachlan

Cellular Thyroid Peroxidase (TPO), Unlike Purified TPO and Adjuvant, Induces Antibodies in Mice That Resemble Autoantibodies in Human Autoimmune Thyroid Disease
J Clin Endocrinol Metab 1999 84: 1651-1657 doi:10.1210/jc.84.5.1651 [Abstract] [Full Text] [PDF]  

P. M. Piatti, L. D. Monti, A. Caumo, M. Conti, F. Magni, M. Galli-Kienle, E. Fochesato, A. Pizzini, L. Baldi, G. Valsecchi, and A. E. Pontiroli

Mediation of the Hepatic Effects of Growth Hormone by Its Lipolytic Activity
J Clin Endocrinol Metab 1999 84: 1658-1663 doi:10.1210/jc.84.5.1658 [Abstract] [Full Text] [PDF]  

Elisabeth Carlsen, Claus Olsson, Jørgen Holm Petersen, Anna-Maria Andersson, and Niels E Skakkebæk

Diurnal Rhythm in Serum Levels of Inhibin B in Normal Men: Relation to Testicular Steroids and Gonadotropins
J Clin Endocrinol Metab 1999 84: 1664-1669 doi:10.1210/jc.84.5.1664 [Abstract] [Full Text] [PDF]  

Michaela Luconi, Monica Muratori, Gianni Forti, and Elisabetta Baldi

Identification and Characterization of a Novel Functional Estrogen Receptor on Human Sperm Membrane That Interferes with Progesterone Effects
J Clin Endocrinol Metab 1999 84: 1670-1678 doi:10.1210/jc.84.5.1670 [Abstract] [Full Text] [PDF]  

Matthias M. Weber, Gerald Spöttl, Christoph Gössl, and Dieter Engelhardt

Characterization of Human Insulin-Like Growth Factor-Binding Proteins by Two-Dimensional Polyacrylamide Gel Electrophoresis and Western Ligand Blot Analysis
J Clin Endocrinol Metab 1999 84: 1679-1684 doi:10.1210/jc.84.5.1679 [Abstract] [Full Text] [PDF]  

Pamela Correa, Jonas Rastad, Peter Schwarz, Gunnar Westin, Andreas Kindmark, Ewa Lundgren, Göran Åkerström, and Tobias Carling

The Vitamin D Receptor (VDR) Start Codon Polymorphism in Primary Hyperparathyroidism and Parathyroid VDR Messenger Ribonucleic Acid Levels
J Clin Endocrinol Metab 1999 84: 1690-1694 doi:10.1210/jc.84.5.1690 [Abstract] [Full Text] [PDF]  

Andreas Festa, Walter Krugluger, Nadja Shnawa, Pierre Hopmeier, Steven M. Haffner, and Guntram Schernthaner

Trp⁶⁴Arg Polymorphism of the ß₃-Adrenergic Receptor Gene in Pregnancy: Association with Mild Gestational Diabetes Mellitus
J Clin Endocrinol Metab 1999 84: 1695-1699 doi:10.1210/jc.84.5.1695 [Abstract] [Full Text] [PDF]  

Pascal Pigny, Catherine Bauters, Jean-Louis Wemeau, Martine Lecomte Houcke, Michel Crepin, Philippe Caron, Sophie Giraud, Alain Calender, Marie-Pierre Buisine, Jean-Pierre Kerckaert, and Nicole Porchet

A Novel 9-Base Pair Duplication in RET Exon 8 in Familial Medullary Thyroid Carcinoma
J Clin Endocrinol Metab 1999 84: 1700-1704 doi:10.1210/jc.84.5.1700 [Abstract] [Full Text] [PDF]  

Colette Sparey, Stephen C. Robson, Jarrod Bailey, Fiona Lyall, and G. Nicholas Europe-Finner

The Differential Expression of Myometrial Connexin-43, Cyclooxygenase-1 and -2, and G_s Proteins in the Upper and Lower Segments of the Human Uterus during Pregnancy and Labor
J Clin Endocrinol Metab 1999 84: 1705-1710 doi:10.1210/jc.84.5.1705 [Abstract] [Full Text] [PDF]  

Juha S. Tapanainen, Riitta Koivunen, Bart C. J. M. Fauser, Ann E. Taylor, Richard N. Clayton, Madhurima Rajkowa, Davinia White, Stephen Franks, Leena Anttila, Kim S. I. Pettersson, and Ilpo T. Huhtaniemi

A New Contributing Factor to Polycystic Ovary Syndrome: The Genetic Variant of Luteinizing Hormone
J Clin Endocrinol Metab 1999 84: 1711-1715 doi:10.1210/jc.84.5.1711 [Abstract] [Full Text] [PDF]  

F. Homero D’Abronzo, Brooke Swearingen, Anne Klibanski, and Joseph M. Alexander

Mutational Analysis of Activin/Transforming Growth Factor-ß Type I and Type II Receptor Kinases in Human Pituitary Tumors
J Clin Endocrinol Metab 1999 84: 1716-1721 doi:10.1210/jc.84.5.1716 [Abstract] [Full Text] [PDF]  

Alberto Pugliese, Eiji Kawasaki, Markus Zeller, Liping Yu, Sunanda Babu, Michele Solimena, Carlos T. Moraes, Massimo Pietropaolo, Robert P. Friday, Massimo Trucco, Camillo Ricordi, Marie Allen, Janelle A. Noble, Henry A. Erlich, and George S. Eisenbarth

Sequence Analysis of the Diabetes-Protective Human Leukocyte Antigen-DQB10602 Allele in Unaffected, Islet Cell Antibody-Positive First Degree Relatives and in Rare Patients with Type 1 Diabetes
J Clin Endocrinol Metab 1999 84: 1722-1728 doi:10.1210/jc.84.5.1722 [Abstract] [Full Text] [PDF]  

M. Dahmoun, K. Boman, S. Cajander, P. Westin, and T. Bäckström

Apoptosis, Proliferation, and Sex Hormone Receptors in Superficial Parts of Human Endometrium at the End of the Secretory Phase
J Clin Endocrinol Metab 1999 84: 1737-1743 doi:10.1210/jc.84.5.1737 [Abstract] [Full Text] [PDF]  

S. Fritz, K. J. Föhr, S. Boddien, U. Berg, C. Brucker, and A. Mayerhofer

Functional and Molecular Characterization of a Muscarinic Receptor Type and Evidence for Expression of Choline-Acetyltransferase and Vesicular Acetylcholine Transporter in Human Granulosa-Luteal Cells
J Clin Endocrinol Metab 1999 84: 1744-1750 doi:10.1210/jc.84.5.1744 [Abstract] [Full Text] [PDF]  

Brigitta Thiele, Wolfgang Weidemann, Doris Schnabel, Gabriela Romalo, Hans-Udo Schweikert, and Klaus-Dieter Spindler

COMMENTS:Complete Androgen Insensitivity Caused by a New Frameshift Deletion of Two Base Pairs in Exon 1 of the Human Androgen Receptor Gene
J Clin Endocrinol Metab 1999 84: 1751-1753 doi:10.1210/jc.84.5.1751 [Abstract] [Full Text] [PDF]  

From the Clinical Research Centers:

Keiichi Hanaki, Dorothy J. Becker, and Silva A. Arslanian

Leptin Before and After Insulin Therapy in Children with New-Onset Type 1 Diabetes
J Clin Endocrinol Metab 1999 84: 1524-1526 doi:10.1210/jc.84.5.1524 [Abstract] [Full Text] [PDF]  

Francesco Facchini, Michael H. Humphreys, Jorgen Jeppesen, and Gerald M. Reaven

Measurements of Insulin-Mediated Glucose Disposal Are Stable Over Time
J Clin Endocrinol Metab 1999 84: 1567-1569 doi:10.1210/jc.84.5.1567 [Abstract] [Full Text] [PDF]  

F. John Service, Neena Natt, Geoffrey B. Thompson, Clive S. Grant, Jonathan A. van Heerden, James C. Andrews, Eva Lorenz, Andre Terzic, and Ricardo V. Lloyd

Noninsulinoma Pancreatogenous Hypoglycemia: A Novel Syndrome of Hyperinsulinemic Hypoglycemia in Adults Independent of Mutations in Kir6.2 and SUR1 Genes
J Clin Endocrinol Metab 1999 84: 1582-1589 doi:10.1210/jc.84.5.1582 [Abstract] [Full Text] [PDF]  

Yuan-Shan Zhu, Li-Qun Cai, Juan J. Cordero, William J. Canovatchel, Melissa D. Katz, and Julianne Imperato-McGinley

A Novel Mutation in the CAG Triplet Region of Exon 1 of Androgen Receptor Gene Causes Complete Androgen Insensitivity Syndrome in a Large Kindred
J Clin Endocrinol Metab 1999 84: 1590-1594 doi:10.1210/jc.84.5.1590 [Abstract] [Full Text] [PDF]  

Kathryn E. Graham, Mary H. Samuels, Gary M. Nesbit, David M. Cook, Oisin R. O’Neill, Stanley L. Barnwell, and D. Lynn Loriaux

Cavernous Sinus Sampling Is Highly Accurate in Distinguishing Cushing’s Disease from the Ectopic Adrenocorticotropin Syndrome and in Predicting Intrapituitary Tumor Location
J Clin Endocrinol Metab 1999 84: 1602-1610 doi:10.1210/jc.84.5.1602 [Abstract] [Full Text] [PDF]  

Manubai Nagamani, Collins Osuampke, and Mae Ellen Kelver

Increased Bioactive Luteinizing Hormone Levels and Bio/Immuno Ratio in Women with Hyperthecosis of the Ovaries: Possible Role of Hyperinsulinemia
J Clin Endocrinol Metab 1999 84: 1685-1689 doi:10.1210/jc.84.5.1685 [Abstract] [Full Text] [PDF]  

Rapid Communications:

Kentaro Yamada, Satomi Ishiyama-Shigemoto, Fumi Ichikawa, Xiaohong Yuan, Atsuko Koyanagi, Wasaku Koyama, and Kyohei Nonaka

Polymorphism in the 5'-Leader Cistron of the ß₂-Adrenergic Receptor Gene Associated with Obesity and Type 2 Diabetes
J Clin Endocrinol Metab 1999 84: 1754-1757 doi:10.1210/jc.84.5.1754 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Damiano Gullo, Laura Sciacca, Giuseppina Parrinello, Letizia Tomaselli, and Riccardo Vigneri

Treatment of Hemangiopericytoma-Induced Hypoglycemia with Growth Hormone and Corticosteroids
J Clin Endocrinol Metab 1999 84: 1758-1759 doi:10.1210/jc.84.5.1758 [Full Text] [PDF]  

Leonard Wartofsky, Kenneth D. Burman, and Matthew D. Ringel

Trading One "Dangerous Dogma" for Another? Thyroid Hormone Treatment of the "Euthyroid Sick Syndrome"
J Clin Endocrinol Metab 1999 84: 1759 doi:10.1210/jc.84.5.1759 [Full Text] [PDF]  

Leslie J. DeGroot

Dangerous Dogmas in Medicine—Author’s Response
J Clin Endocrinol Metab 1999 84: 1759a-1760a doi:10.1210/jc.84.5.1759-a [Full Text] [PDF]  

He Yu

Comment on Association between Insulin-Like Growth Factor-I (IGF-I) and Bone Mineral Density: Further Evidence Linking IGF-I to Breast Cancer Risk
J Clin Endocrinol Metab 1999 84: 1760-1761 doi:10.1210/jc.84.5.1760 [Full Text] [PDF]  

Clifford J. Rosen, Douglas P. Kiel, Jean A. Langlois, and Marjolein Visser

Association between Insulin-Like Growth Factor (IGF-I) and Bone Mineral Density: Further Evidence Linking IGF-I to Breast Cancer Risk—Authors’ Response
J Clin Endocrinol Metab 1999 84: 1761 doi:10.1210/jc.84.5.1761 [Full Text] [PDF]  

Janusz Krassowski, Wojciech Zgliczynski, Wojciech Jeske, and Stefan Zgliczynski

Comment on Long-Acting Lanreotide Inducing Clinical and Biochemical Remission of Acromegaly Caused by Disseminated GHRH Secreting Carcinoid
J Clin Endocrinol Metab 1999 84: 1761a-1762a doi:10.1210/jc.84.5.1761-a [Full Text] [PDF]  

Stefano Laureti, Luigi Vecchi, Fausto Santeusanio, and Alberto Falorni

Is the Prevalence of Addison’s Disease Underestimated?
J Clin Endocrinol Metab 1999 84: 1762 doi:10.1210/jc.84.5.1762 [Full Text] [PDF]  

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