Articles listed in blue may be of special interest to clinicians.

Special Articles:

Christie M. Ballantyne

CLINICAL PERSPECTIVE: Hyperlipidemia: Diagnostic and Therapeutic Perspectives:Primary Prevention of Coronary Heart Disease
J Clin Endocrinol Metab 2000 85: 2089-2092 doi:10.1210/jc.85.6.2089 [Full Text] [PDF]  

Scott M. Grundy

CLINICAL PERSPECTIVE: Hyperlipidemia: Diagnostic and Therapeutic Perspectives:Cholesterol-Lowering Therapy in Secondary Prevention: Remaining Issues
J Clin Endocrinol Metab 2000 85: 2092-2098 doi:10.1210/jc.85.6.2092 [Full Text] [PDF]  

Albert Oberman

CLINICAL PERSPECTIVE: Hyperlipidemia: Diagnostic and Therapeutic Perspectives:Hypertriglyceridemia and Coronary Heart Disease
J Clin Endocrinol Metab 2000 85: 2098-2105 doi:10.1210/jc.85.6.2098 [Full Text] [PDF]  

Richard J. Havel and Philip H. Frost

CLINICAL PERSPECTIVE: Hyperlipidemia: Diagnostic and Therapeutic Perspectives:The Role of Non-High-Density Lipoprotein-Cholesterol in Evaluation and Treatment of Lipid Disorders
J Clin Endocrinol Metab 2000 85: 2105-2108 doi:10.1210/jc.85.6.2105 [Full Text] [PDF]  

Steven M. Haffner

CLINICAL PERSPECTIVE: Hyperlipidemia: Diagnostic and Therapeutic Perspectives:Is All Coronary Heart Disease Prevention in Type 2 Diabetes Mellitus Secondary Prevention?
J Clin Endocrinol Metab 2000 85: 2108-2110 doi:10.1210/jc.85.6.2108 [Full Text] [PDF]  

Robert A. Kreisberg

CLINICAL PERSPECTIVE: Hyperlipidemia: Diagnostic and Therapeutic Perspectives:—Random Thoughts and Opinions
J Clin Endocrinol Metab 2000 85: 2110-2112 doi:10.1210/jc.85.6.2110 [Full Text] [PDF]  

John E. Gerich

CLINICAL PERSPECTIVE:Insulin Resistance Is Not Necessarily an Essential Component of Type 2 Diabetes
J Clin Endocrinol Metab 2000 85: 2113-2115 doi:10.1210/jc.85.6.2113 [Full Text] [PDF]  

Takashi Akamizu, Leonard D. Kohn, Hitomi Hiratani, Misa Saijo, Kazuo Tahara, and Kazuwa Nakao

CLINICAL CASE SEMINAR:Hashimoto’s Thyroiditis with Heterogeneous Antithyrotropin Receptor Antibodies: Unique Epitopes May Contribute to the Regulation of Thyroid Function by the Antibodies
J Clin Endocrinol Metab 2000 85: 2116-2121 doi:10.1210/jc.85.6.2116 [Abstract] [Full Text] [PDF]  

M. Thearle, M. Horlick, J. P. Bilezikian, J. Levy, J. M. Gertner, L. S. Levine, M. Harbison, W. Berdon, and S. E. Oberfield

CLINICAL CASE SEMINAR:Osteoporosis: An Unusual Presentation of Childhood Crohn’s Disease
J Clin Endocrinol Metab 2000 85: 2122-2126 doi:10.1210/jc.85.6.2122 [Abstract] [Full Text] [PDF]  

Mara Horwitz, Andrew Stewart, and Susan L. Greenspan

EDITORIAL:Sequential Parathyroid Hormone/Alendronate Therapy for Osteoporosis—Robbing Peter to Pay Paul?
J Clin Endocrinol Metab 2000 85: 2127-2128 doi:10.1210/jc.85.6.2127 [Full Text] [PDF]  

Roger S. Rittmaster, Michael Bolognese, Mark P. Ettinger, David A. Hanley, Anthony B. Hodsman, David L. Kendler, and Clifford J. Rosen

Enhancement of Bone Mass in Osteoporotic Women with Parathyroid Hormone followed by Alendronate
J Clin Endocrinol Metab 2000 85: 2129-2134 doi:10.1210/jc.85.6.2129 [Abstract] [Full Text] [PDF]  

Richard J. Wurtman

EDITORIAL:Age-Related Decreases in Melatonin Secretion—Clinical Consequences
J Clin Endocrinol Metab 2000 85: 2135-2136 doi:10.1210/jc.85.6.2135 [Full Text] [PDF]  

R. Salti, F. Galluzzi, G. Bindi, F. Perfetto, R. Tarquini, F. Halberg, and G. Cornélissen

Nocturnal Melatonin Patterns in Children
J Clin Endocrinol Metab 2000 85: 2137-2144 doi:10.1210/jc.85.6.2137 [Abstract] [Full Text] [PDF]  

Philip E. Cryer

EDITORIAL:Are Gender Differences in the Responses to Hypoglycemia Relevant to Iatrogenic Hypoglycemia in Type 1 Diabetes?
J Clin Endocrinol Metab 2000 85: 2145-2147 doi:10.1210/jc.85.6.2145 [Full Text] [PDF]  

S. N. Davis, C. Shavers, and F. Costa

Gender-Related Differences in Counterregulatory Responses to Antecedent Hypoglycemia in Normal Humans
J Clin Endocrinol Metab 2000 85: 2148-2157 doi:10.1210/jc.85.6.2148 [Abstract] [Full Text] [PDF]  

John W. Funder

EDITORIAL:Sex and the Single Gene—FH-1
J Clin Endocrinol Metab 2000 85: 2158-2159 doi:10.1210/jc.85.6.2158 [Full Text] [PDF]  

Michael Stowasser, Anthony W. Bachmann, Phillip R. Huggard, Tony R. Rossetti, and Richard D. Gordon

Severity of Hypertension in Familial Hyperaldosteronism Type I: Relationship to Gender and Degree of Biochemical Disturbance
J Clin Endocrinol Metab 2000 85: 2160-2166 doi:10.1210/jc.85.6.2160 [Abstract] [Full Text] [PDF]  

Gail K. Adler

EDITORIAL:Exercise and Fatigue—Is Neuroendocrinology an Important Factor?
J Clin Endocrinol Metab 2000 85: 2167-2169 doi:10.1210/jc.85.6.2167 [Full Text] [PDF]  

Didier Laurent, Kevin E. Schneider, William K. Prusaczyk, Carole Franklin, Suzanne M. Vogel, Martin Krssak, Kitt Falk Petersen, Harold W. Goforth, and Gerald I. Shulman

Effects of Caffeine on Muscle Glycogen Utilization and the Neuroendocrine Axis during Exercise
J Clin Endocrinol Metab 2000 85: 2170-2175 doi:10.1210/jc.85.6.2170 [Abstract] [Full Text] [PDF]  

BOOK REVIEW:Growth Disorders: Pathophysiology and Treatment
J Clin Endocrinol Metab 2000 85: 2176-2177 doi:10.1210/jc.85.6.2176 [Abstract] [Full Text] [PDF]  

From the Clinical Research Centers:

Ken C. Chiu, Lee-Ming Chuang, Jennifer M. Ryu, George P. Tsai, and Mohammed F. Saad

The I27L Amino Acid Polymorphism of Hepatic Nuclear Factor-1 Is Associated with Insulin Resistance
J Clin Endocrinol Metab 2000 85: 2178-2183 doi:10.1210/jc.85.6.2178 [Abstract] [Full Text] [PDF]  

Jardena J. Puder, Pamela U. Freda, Robin S. Goland, Michel Ferin, and Sharon L. Wardlaw

Stimulatory Effects of Stress on Gonadotropin Secretion in Estrogen-Treated Women
J Clin Endocrinol Metab 2000 85: 2184-2188 doi:10.1210/jc.85.6.2184 [Abstract] [Full Text] [PDF]  

Jamie M. Zeitzer, Najib T. Ayas, Steven A. Shea, Robert Brown, and Charles A. Czeisler

Absence of Detectable Melatonin and Preservation of Cortisol and Thyrotropin Rhythms in Tetraplegia
J Clin Endocrinol Metab 2000 85: 2189-2196 doi:10.1210/jc.85.6.2189 [Abstract] [Full Text] [PDF]  

Karen M. Prestwood, Michele Gunness, Douglas B. Muchmore, Yili Lu, Mayme Wong, and Lawrence G. Raisz

A Comparison of the Effects of Raloxifene and Estrogen on Bone in Postmenopausal Women
J Clin Endocrinol Metab 2000 85: 2197-2202 doi:10.1210/jc.85.6.2197 [Abstract] [Full Text] [PDF]  

M. Bergendahl, A. Iranmanesh, T. Mulligan, and J. D. Veldhuis

Impact of Age on Cortisol Secretory Dynamics Basally and as Driven by Nutrient-Withdrawal Stress
J Clin Endocrinol Metab 2000 85: 2203-2214 doi:10.1210/jc.85.6.2203 [Abstract] [Full Text] [PDF]  

Original Studies:

Roger Abs, Johan Verhelst, Jan Maeyaert, Jean-Pierre Van Buyten, Frank Opsomer, Hugo Adriaensen, Jan Verlooy, Tony Van Havenbergh, Mike Smet, and Kristien Van Acker

Endocrine Consequences of Long-Term Intrathecal Administration of Opioids
J Clin Endocrinol Metab 2000 85: 2215-2222 doi:10.1210/jc.85.6.2215 [Abstract] [Full Text] [PDF]  

Stéphane Blanc, Sylvie Normand, Christiane Pachiaudi, Jacques-Olivier Fortrat, Martine Laville, and Claude Gharib

Fuel Homeostasis during Physical Inactivity Induced by Bed Rest
J Clin Endocrinol Metab 2000 85: 2223-2233 doi:10.1210/jc.85.6.2223 [Abstract] [Full Text] [PDF]  

Massimo Terzolo, Anna Pia, Alfredo Berruti, Giangiacomo Osella, Anna Alì, Valentino Carbone, Elio Testa, Luigi Dogliotti, and Alberto Angeli

Low-Dose Monitored Mitotane Treatment Achieves the Therapeutic Range with Manageable Side Effects in Patients with Adrenocortical Cancer
J Clin Endocrinol Metab 2000 85: 2234-2238 doi:10.1210/jc.85.6.2234 [Abstract] [Full Text] [PDF]  

Suzanne M. Jan de Beur, Chang-Lin Ding, Michele C. LaBuda, Ted B. Usdin, and Michael A. Levine

Pseudohypoparathyroidism 1b: Exclusion of Parathyroid Hormone and Its Receptors as Candidate Disease Genes
J Clin Endocrinol Metab 2000 85: 2239-2246 doi:10.1210/jc.85.6.2239 [Abstract] [Full Text] [PDF]  

Annamaria Colao, Antonella Di Sarno, Maria Luisa Landi, Francesco Scavuzzo, Paolo Cappabianca, Rosario Pivonello, Raffaele Volpe, Francesco Di Salle, Sossio Cirillo, Lucio Annunziato, and Gaetano Lombardi

Macroprolactinoma Shrinkage during Cabergoline Treatment Is Greater in Naive Patients Than in Patients Pretreated with Other Dopamine Agonists: A Prospective Study in 110 Patients
J Clin Endocrinol Metab 2000 85: 2247-2252 doi:10.1210/jc.85.6.2247 [Abstract] [Full Text] [PDF]  

Aleksander Giwercman, Thomas Kledal, Marianne Schwartz, Yvonne Lundberg Giwercman, Henrik Leffers, Henric Zazzi, Anna Wedell, and Niels E. Skakkebæk

Preserved Male Fertility Despite Decreased Androgen Sensitivity Caused by a Mutation in the Ligand-Binding Domain of the Androgen Receptor Gene
J Clin Endocrinol Metab 2000 85: 2253-2259 doi:10.1210/jc.85.6.2253 [Abstract] [Full Text] [PDF]  

Giovanni Ravaglia, Paola Forti, Fabiola Maioli, Barbara Nesi, Loredana Pratelli, Lucia Savarino, Domenico Cucinotta, and Giancarlo Cavalli

Blood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old
J Clin Endocrinol Metab 2000 85: 2260-2265 doi:10.1210/jc.85.6.2260 [Abstract] [Full Text] [PDF]  

Leo Niskanen, Matti K. Karvonen, Raisa Valve, Markku Koulu, Ullamari Pesonen, Michele Mercuri, Rainer Rauramaa, Jari Töyry, Markku Laakso, and Matti I. J. Uusitupa

Leucine 7 to Proline 7 Polymorphism in the Neuropeptide Y Gene Is Associated with Enhanced Carotid Atherosclerosis in Elderly Patients with Type 2 Diabetes and Control Subjects
J Clin Endocrinol Metab 2000 85: 2266-2269 doi:10.1210/jc.85.6.2266 [Abstract] [Full Text] [PDF]  

Massimo Tonacchera, Patrizia Agretti, Luca Chiovato, Veronica Rosellini, Giovanni Ceccarini, Anna Perri, Paolo Viacava, Antonio Giuseppe Naccarato, Paolo Miccoli, Aldo Pinchera, and Paolo Vitti

Activating Thyrotropin Receptor Mutations Are Present in Nonadenomatous Hyperfunctioning Nodules of Toxic or Autonomous Multinodular Goiter
J Clin Endocrinol Metab 2000 85: 2270-2274 doi:10.1210/jc.85.6.2270 [Abstract] [Full Text] [PDF]  

Michael E. Røder, Robert S. Schwartz, Ronald L. Prigeon, and Steven E. Kahn

Reduced Pancreatic B Cell Compensation to the Insulin Resistance of Aging: Impact on Proinsulin and Insulin Levels
J Clin Endocrinol Metab 2000 85: 2275-2280 doi:10.1210/jc.85.6.2275 [Abstract] [Full Text] [PDF]  

Jörg Gromoll, Urs Eiholzer, Eberhard Nieschlag, and Manuela Simoni

Male Hypogonadism Caused by Homozygous Deletion of Exon 10 of the Luteinizing Hormone (LH) Receptor: Differential Action of Human Chorionic Gonadotropin and LH
J Clin Endocrinol Metab 2000 85: 2281-2286 doi:10.1210/jc.85.6.2281 [Abstract] [Full Text] [PDF]  

A. Schäffler, N. Barth, K. Winkler, B. Zietz, P. Rümmele, R. Knüchel, J. Schölmerich, and K.-D. Palitzsch

Identification of a New Missense Mutation (Gly95Glu) in a Highly Conserved Codon within the High-Mobility Group Box of the Sex-Determining Region Y Gene: Report on a 46,XY Female with Gonadal Dysgenesis and Yolk-Sac Tumor
J Clin Endocrinol Metab 2000 85: 2287-2292 doi:10.1210/jc.85.6.2287 [Abstract] [Full Text] [PDF]  

Beatrice Couzinet, Jacques Pantel, Philippe Chanson, Jacques Young, Sylvie Brailly, Ilpo T. Huhtaniemi, Jean-Michel Bidart, and Gilbert Schaison

Measurement of Plasma Free Luteinizing Hormone ß-Subunit in Women
J Clin Endocrinol Metab 2000 85: 2293-2298 doi:10.1210/jc.85.6.2293 [Abstract] [Full Text] [PDF]  

Sean Ercan-Fang, Harold L. Schwartz, Cary N. Mariash, and Jack H. Oppenheimer

Quantitative Assessment of Pituitary Resistance to Thyroid Hormone from Plots of the Logarithm of Thyrotropin Versus Serum Free Thyroxine Index
J Clin Endocrinol Metab 2000 85: 2299-2303 doi:10.1210/jc.85.6.2299 [Abstract] [Full Text] [PDF]  

Jessica K. Wickenheisser, Patrick G. Quinn, Velen L. Nelson, Richard S. Legro, Jerome F. Strauss, III, and Jan M. McAllister.

Differential Activity of the Cytochrome P450 17-Hydroxylase and Steroidogenic Acute Regulatory Protein Gene Promoters in Normal and Polycystic Ovary Syndrome Theca Cells
J Clin Endocrinol Metab 2000 85: 2304-2311 doi:10.1210/jc.85.6.2304 [Abstract] [Full Text] [PDF]  

Jonathan H. Pinkney, Olivier Boss, George A. Bray, Karen Bulmer, Simon W. Coppack, and Vidya Mohamed-Ali

Physiological Relationships of Uncoupling Protein-2 Gene Expression in Human Adipose Tissue in Vivo
J Clin Endocrinol Metab 2000 85: 2312-2317 doi:10.1210/jc.85.6.2312 [Abstract] [Full Text] [PDF]  

Maddalena Napolitano, Fiorella Miceli, Angelica Calce, Alessandra Vacca, Alberto Gulino, Rosanna Apa, and Antonio Lanzone

Expression and Relationship between Endothelin-1 Messenger Ribonucleic Acid (mRNA) and Inducible/Endothelial Nitric Oxide Synthase mRNA Isoforms from Normal and Preeclamptic Placentas
J Clin Endocrinol Metab 2000 85: 2318-2323 doi:10.1210/jc.85.6.2318 [Abstract] [Full Text] [PDF]  

Koit Reimand, Pärt Peterson, Heikki Hyöty, Raivo Uibo, Ian Cooke, Anthony P. Weetman, and Kai J. E. Krohn

3ß-Hydroxysteroid Dehydrogenase Autoantibodies Are Rare in Premature Ovarian Failure
J Clin Endocrinol Metab 2000 85: 2324-2326 doi:10.1210/jc.85.6.2324 [Abstract] [Full Text] [PDF]  

Anastasia Diamandi, Jehangir Mistry, Radha G. Krishna, and Javad Khosravi

Immunoassay of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3): New Means to Quantifying IGFBP-3 Proteolysis
J Clin Endocrinol Metab 2000 85: 2327-2333 doi:10.1210/jc.85.6.2327 [Abstract] [Full Text] [PDF]  

George L. Mutter, Ming-Chieh Lin, Jeffrey T. Fitzgerald, Jennifer B. Kum, and Charis Eng

Changes in Endometrial PTEN Expression throughout the Human Menstrual Cycle
J Clin Endocrinol Metab 2000 85: 2334-2338 doi:10.1210/jc.85.6.2334 [Abstract] [Full Text] [PDF]  

Sarah E. Dickson and Hamish M. Fraser

Inhibition of Early Luteal Angiogenesis by Gonadotropin-Releasing Hormone Antagonist Treatment in the Primate
J Clin Endocrinol Metab 2000 85: 2339-2344 doi:10.1210/jc.85.6.2339 [Abstract] [Full Text] [PDF]  

Rapid Communications:

Mark McLean, Maria Bowman, Vicki Clifton, Roger Smith, and Ashley B. Grossman

Expression of the Heme Oxygenase-Carbon Monoxide Signalling System in Human Placenta
J Clin Endocrinol Metab 2000 85: 2345-2349 doi:10.1210/jc.85.6.2345 [Abstract] [Full Text] [PDF]  

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