The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2008 93: 17a-20a [Full Text] [PDF]  

Special Features:

Mark S. Anderson

UPDATE:Update in Endocrine Autoimmunity
J Clin Endocrinol Metab 2008 93: 3663-3670 [Abstract] [Full Text] [PDF]  
Recent progress made in understanding the genetics, diagnosis, and treatment of endocrine autoimmune diseases is reviewed.

James L. Rosenzweig, Ele Ferrannini, Scott M. Grundy, Steven M. Haffner, Robert J. Heine, Edward S. Horton, and Ryuzo Kawamori

CLINICAL PRACTICE GUIDELINE:Primary Prevention of Cardiovascular Disease and Type 2 Diabetes in Patients at Metabolic Risk: An Endocrine Society Clinical Practice Guideline
J Clin Endocrinol Metab 2008 93: 3671-3689; first published July 29 2008 as doi:10.1210/jc.2008-0222 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
This Endocrine Society clinical practice guideline offers advice for primary prevention of cardiovascular disease and type 2 diabetes mellitus in patients at metabolic risk.

John R. Hoyt and Christopher M. Wittich

IMAGE IN ENDOCRINOLOGY:Diabetic Myonecrosis
J Clin Endocrinol Metab 2008 93: 3690 [Full Text] [PDF]  

A. Deeb, J. Jääskeläinen, M. Dattani, H. C. Whitaker, C. Costigan, and I. A. Hughes

CLINICAL CASE SEMINAR:A Novel Mutation in the Human Androgen Receptor Suggests a Regulatory Role for the Hinge Region in Amino-Terminal and Carboxy-Terminal Interactions
J Clin Endocrinol Metab 2008 93: 3691-3696; first published August 12 2008 as doi:10.1210/jc.2008-0737 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
A novel mutation (Arg629Trp) in the androgen receptor hinge region is found to impair N/C domain interaction in the presence of normal androgen receptor binding and nuclear localization, and to cause severe undermasculinization at birth and resistance to androgens, thus confirming a unique regulatory role for this region in androgen receptor function.

Sumito Dateki, Maki Fukami, Naoko Sato, Kouji Muroya, Masanori Adachi, and Tsutomu Ogata

CLINICAL CASE SEMINAR:OTX2 Mutation in a Patient with Anophthalmia, Short Stature, and Partial Growth Hormone Deficiency: Functional Studies Using the IRBP, HESX1, and POU1F1 Promoters
J Clin Endocrinol Metab 2008 93: 3697-3702; first published July 15 2008 as doi:10.1210/jc.2008-0720 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
The homeobox gene OTX2 for ocular development has a transactivation function for the promoters of HESX1 and POU1F1, which are involved in the early and late stages of pituitary development, respectively.

Chee W. Chia and Josephine M. Egan

CLINICAL REVIEW:Incretin-Based Therapies in Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 2008 93: 3703-3716; first published July 15 2008 as doi:10.1210/jc.2007-2109 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[GLP-1-based therapies for the treatment of type 2 diabetes mellitus]
The use of glucagon-like peptide 1 mimetics and dipeptidyl peptidase 4 inhibitors in treating type 2 diabetes mellitus in selected clinical trials is reviewed.

O. M. Dekkers, A. M. Pereira, and J. A. Romijn

CLINICAL REVIEW:Treatment and Follow-Up of Clinically Nonfunctioning Pituitary Macroadenomas
J Clin Endocrinol Metab 2008 93: 3717-3726; first published August 5 2008 as doi:10.1210/jc.2008-0643 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Treatment of gonadotroph and other clinically nonfunctioning adenomas]
Although benign in nature, clinically nonfunctioning pituitary macroadenomas need individualized treatment and lifelong radiological and endocrinological follow-up.

Steven E. Kahn and William T. Cefalu

COMMENTARY:Glucose Control, Macro- and Microvascular Disease, and the Food and Drug Administration: Let’s Keep Our Eye on the Ball
J Clin Endocrinol Metab 2008 93: 3727-3729; first published September 2 2008 as doi:10.1210/jc.2008-1799 [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Hui Huang and Tito Fojo

COMMENTARY:Adjuvant Mitotane for Adrenocortical Cancer—A Recurring Controversy
J Clin Endocrinol Metab 2008 93: 3730-3732 [Full Text] [PDF]  

Editorials:

Douglas C. Bauer

EDITORIAL:Randomized Trial Reporting in General Endocrine Journals: The Good, the Bad, and the Ugly
J Clin Endocrinol Metab 2008 93: 3733-3734 [Full Text] [PDF]  

Endocrine Care:

J. Fleischer, E. M. Stein, M. Bessler, M. Della Badia, N. Restuccia, L. Olivero-Rivera, D. J. McMahon, and S. J. Silverberg

The Decline in Hip Bone Density after Gastric Bypass Surgery Is Associated with Extent of Weight Loss
J Clin Endocrinol Metab 2008 93: 3735-3740; first published July 22 2008 as doi:10.1210/jc.2008-0481 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Severely obese patients who undergo Roux-en-Y gastric bypass surgery have calcium and vitamin D malabsorption, increased bone turnover, and rapid declines in hip bone density. The decrease in hip bone mineral density is strongly associated with the extent of weight loss.

M. J. H. J. Dekker, J. W. Koper, M. O. van Aken, H. A. P. Pols, A. Hofman, F. H. de Jong, C. Kirschbaum, J. C. M. Witteman, S. W. J. Lamberts, and H. Tiemeier

Salivary Cortisol Is Related to Atherosclerosis of Carotid Arteries
J Clin Endocrinol Metab 2008 93: 3741-3747; first published August 5 2008 as doi:10.1210/jc.2008-0496 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In an elderly population, higher total cortisol exposure while awake is independently associated with a higher number of carotid artery atherosclerotic plaques.

Wojciech Kosmala, Trisha M. O'Moore-Sullivan, Rafal Plaksej, Justyna Kuliczkowska-Plaksej, Monika Przewlocka-Kosmala, and Thomas H. Marwick

Subclinical Impairment of Left Ventricular Function in Young Obese Women: Contributions of Polycystic Ovary Disease and Insulin Resistance
J Clin Endocrinol Metab 2008 93: 3748-3754; first published August 5 2008 as doi:10.1210/jc.2008-1017 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In young obese females, impaired cardiac performance is correlated independently with fasting insulin, body mass index, sex hormone binding globulin, and urinary albumin excretion. The contribution of polycystic ovary syndrome to left ventricular function abnormalities in these subjects is accounted for by insulin resistance, but not other coexisting hormonal aberrations.

Jean-Marc Kaufman, Agnès Ostertag, Aude Saint-Pierre, Martine Cohen-Solal, Anne Boland, Inge Van Pottelbergh, Kaatje Toye, Marie-Christine de Vernejoul, and Maria Martinez

Genome-Wide Linkage Screen of Bone Mineral Density (BMD) in European Pedigrees Ascertained through a Male Relative with Low BMD Values: Evidence for Quantitative Trait Loci on 17q21–23, 11q12–13, 13q12–14, and 22q11
J Clin Endocrinol Metab 2008 93: 3755-3762; first published July 29 2008 as doi:10.1210/jc.2008-0678 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
A genome-wide linkage screen for genes underlying bone mineral density variation in European pedigrees having a male relative with low bone mineral density shows both novel (22q11) and previously reported (17q21-23, 11q12-13, 13q12-14) linkage regions.

James Gibney, Marie-Louise Healy, Thomas P. Smith, and T. Joseph McKenna

A Simple and Cost-Effective Approach to Assessment of Pituitary Adrenocorticotropin and Growth Hormone Reserve: Combined Use of the Overnight Metyrapone Test and Insulin-Like Growth Factor-I Standard Deviation Scores
J Clin Endocrinol Metab 2008 93: 3763-3768; first published July 29 2008 as doi:10.1210/jc.2008-0154 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In more than half of patients with organic pituitary disorders, ACTH and GH status can be diagnosed accurately using the overnight metyrapone test and measurement of plasma IGF-I levels, procedures that are more cost-effective than the insulin tolerance test.

Pia R. Kamstrup, Anne Tybjærg-Hansen, Rolf Steffensen, and Børge G. Nordestgaard

Pentanucleotide Repeat Polymorphism, Lipoprotein(a) Levels, and Risk of Ischemic Heart Disease
J Clin Endocrinol Metab 2008 93: 3769-3776; first published August 5 2008 as doi:10.1210/jc.2008-0830 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
In the general population, elevated levels of lipoprotein(a) and low number of apolipoprotein(a) promoter pentanucleotide repeats are associated with a two- to three-fold increased risk of myocardial infarction and ischemic heart disease.

Annamaria Colao, Maurizio Galderisi, Antonella Di Sarno, Moira Pardo, Maria Gaccione, Marianna D'Andrea, Ermelinda Guerra, Rosario Pivonello, Giuseppe Lerro, and Gaetano Lombardi

Increased Prevalence of Tricuspid Regurgitation in Patients with Prolactinomas Chronically Treated with Cabergoline
J Clin Endocrinol Metab 2008 93: 3777-3784; first published August 5 2008 as doi:10.1210/jc.2007-1403 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Treatment of hyperprolactinemia due to lactotroph adenoma and other causes]
Chronic therapy with cabergoline at higher cumulative doses is associated with moderate tricuspid regurgitation in patients with prolactinomas when compared to de novo patients and healthy control subjects, thus indicating that complete echocardiographic assessment is indicated in patients treated long term with cabergoline.

Paul D. Miller, Pierre D. Delmas, Robert Lindsay, Nelson B. Watts, Marjorie Luckey, Jonathan Adachi, Kenneth Saag, Susan L. Greenspan, Ego Seeman, Steven Boonen, Suzanne Meeves, Thomas F. Lang, John P. Bilezikian for the Open-label Study to Determine How Prior Therapy with Alendronate or Risedronate in Postmenopausal Women with Osteoporosis Influences the Clinical Effectiveness of Teriparatide Investigators

Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate
J Clin Endocrinol Metab 2008 93: 3785-3793; first published August 5 2008 as doi:10.1210/jc.2008-0353 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Parathyroid hormone therapy for osteoporosis]
Postmenopausal women with osteoporosis previously treated for at least 2 years with risedronate have a greater response to 1 year of teriparatide than those previously treated with alendronate.

David A. van Tijn, Jan J. M. de Vijlder, and Thomas Vulsma

Role of Corticotropin-Releasing Hormone Testing in Assessment of Hypothalamic-Pituitary-Adrenal Axis Function in Infants with Congenital Central Hypothyroidism
J Clin Endocrinol Metab 2008 93: 3794-3803; first published July 22 2008 as doi:10.1210/jc.2008-0492 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In half of infants, an impaired plasma cortisol rise occurs despite of a substantial of plasma ACTH increase. This newly described 'discordant' response may represent an early phase of hypothalamic-pituitary-adrenal axis dysfunction or a distinct pathogenetic subset.

Taly Meas, Samia Deghmoun, Priscilla Armoogum, Corinne Alberti, and Claire Levy-Marchal

Consequences of Being Born Small for Gestational Age on Body Composition: An 8-Year Follow-Up Study
J Clin Endocrinol Metab 2008 93: 3804-3809; first published July 15 2008 as doi:10.1210/jc.2008-0488 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Adults born small for gestational age have a higher body mass index than adults born appropriate for gestational age, reflecting a greater fat mass with more abdominal fat. The findings suggest a long-term effect of fetal programming in adults.

Lorena P. Rios, Adefowope Odueyungbo, Misha O. Moitri, Mohammed O. Rahman, and Lehana Thabane

Quality of Reporting of Randomized Controlled Trials in General Endocrinology Literature
J Clin Endocrinol Metab 2008 93: 3810-3816; first published June 26 2008 as doi:10.1210/jc.2008-0817 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
This systematic review assesses the reporting quality of randomized controlled trials in general endocrine literature, identifies criteria for better reporting quality, and provides some recommendations for improvement.

Florentia Kaguelidou, Corinne Alberti, Mireille Castanet, Marie-Aline Guitteny, Paul Czernichow, Juliane Léger for the French Childhood Graves’ Disease Study Group

Predictors of Autoimmune Hyperthyroidism Relapse in Children after Discontinuation of Antithyroid Drug Treatment
J Clin Endocrinol Metab 2008 93: 3817-3826; first published July 15 2008 as doi:10.1210/jc.2008-0842 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
A prospective study in children with Graves' disease reveals a strong association between the risk of relapse two years after a course of antithyroid drug treatment and ethnicity, age and disease severity at diagnosis. Duration of treatment seems to be the only influential variable that can be manipulated.

Gareth G. Lavery, Elizabeth A. Walker, Ana Tiganescu, Jon P. Ride, Cedric H. L. Shackleton, Jeremy W. Tomlinson, John M. C. Connell, David W. Ray, Anna Biason-Lauber, Ewa M. Malunowicz, Wiebke Arlt, and Paul M. Stewart

Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency
J Clin Endocrinol Metab 2008 93: 3827-3832; first published July 15 2008 as doi:10.1210/jc.2008-0743 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In four patients with cortisone reductase deficiency, loss of function mutations in hexose-6-phosphate dehydrogenase led to defective 11{beta}-hydroxysteroid dehydrogenase type 1-mediated regeneration of cortisol from cortisone, resulting in activation of the hypothalamic-pituitary-adrenal axis and hyperandrogenism.

Amy Z. Fan, Marcia Russell, Timothy Naimi, Yan Li, Youlian Liao, Ruth Jiles, and Ali H. Mokdad

Patterns of Alcohol Consumption and the Metabolic Syndrome
J Clin Endocrinol Metab 2008 93: 3833-3838; first published July 15 2008 as doi:10.1210/jc.2007-2788 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
This population-based study among U.S. adults indicates that increased risk of the metabolic syndrome is associated with daily consumption of alcohol exceeding U.S. Dietary Guideline recommendations by increasing risk of impaired fasting glucose and diabetes mellitus, hypertriglyceridemia, abdominal obesity, and high blood pressure.

Thomas Linn, Britta Fischer, Nedim Soydan, Michael Eckhard, Julia Ehl, Clemens Kunz, and Reinhard G. Bretzel

Nocturnal Glucose Metabolism after Bedtime Injection of Insulin Glargine or Neutral Protamine Hagedorn Insulin in Patients with Type 2 Diabetes
J Clin Endocrinol Metab 2008 93: 3839-3846; first published July 8 2008 as doi:10.1210/jc.2007-2871 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Variations of the endogenous production of glucose and its rate of disappearance explain the reduced incidence of nocturnal hypoglycemia and lower fasting glucose levels reported for glargine insulin compared to NPH insulin.

MaryFran R. Sowers, Huiyong Zheng, Daniel McConnell, Bin Nan, Siobán D. Harlow, and John F. Randolph, Jr.

Estradiol Rates of Change in Relation to the Final Menstrual Period in a Population-Based Cohort of Women
J Clin Endocrinol Metab 2008 93: 3847-3852; first published July 22 2008 as doi:10.1210/jc.2008-1056 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Patterns in estradiol (E2) levels and rates-of-change occurring 10 years before and after the final menstrual periodare identified in longitudinal data from 629 women. A precipitous decline ({downarrow}67%) in E2 levels began 2 years before the final menstrual period FMP to a plateau of 21 pg/ml at 2 years after. A second significant E2 decline at 6 years after the final menstrual period occurred only in non-obese women.

S. J. C. M. M. Neggers, M. O. van Aken, W. W. de Herder, R. A. Feelders, J. A. M. J. L. Janssen, X. Badia, S. M. Webb, and A. J. van der Lely

Quality of Life in Acromegalic Patients during Long-Term Somatostatin Analog Treatment with and without Pegvisomant
J Clin Endocrinol Metab 2008 93: 3853-3859; first published July 22 2008 as doi:10.1210/jc.2008-0669 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Addition of pegvisomant to long-acting somatostatin analog treatment improves the quality of life of acromegalic patients without a change in IGF-I, thus calling into question current treatment approaches in which pegvisomant is used only when somatostatin analog therapy has failed to normalize IGF-I.

B. Lindegaard, T. Hansen, T. Hvid, G. van Hall, P. Plomgaard, S. Ditlevsen, J. Gerstoft, and B. K. Pedersen

The Effect of Strength and Endurance Training on Insulin Sensitivity and Fat Distribution in Human Immunodeficiency Virus-Infected Patients with Lipodystrophy
J Clin Endocrinol Metab 2008 93: 3860-3869; first published July 15 2008 as doi:10.1210/jc.2007-2733 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In patients with HIV lipodystrophy, both strength and endurance training improves peripheral insulin sensitivity, whereas only strength training reduces total body fat.

Susan A. Hall, Gretchen R. Esche, Andre B. Araujo, Thomas G. Travison, Richard V. Clark, Rachel E. Williams, and John B. McKinlay

Correlates of Low Testosterone and Symptomatic Androgen Deficiency in a Population-Based Sample
J Clin Endocrinol Metab 2008 93: 3870-3877; first published July 29 2008 as doi:10.1210/jc.2008-0021 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
The most important correlate of low testosterone and symptomatic low testosterone is waist circumference, not age.

Esra Tasali, Eve Van Cauter, Leslie Hoffman, and David A. Ehrmann

Impact of Obstructive Sleep Apnea on Insulin Resistance and Glucose Tolerance in Women with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2008 93: 3878-3884; first published July 22 2008 as doi:10.1210/jc.2008-0925 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Clinical manifestations of polycystic ovary syndrome in adults]
Obstructive sleep apnea is highly prevalent among women with polycystic ovary syndrome, and is an important determinant of insulin resistance and glucose intolerance in this population.

Charlotte Brøns, Christine B. Jensen, Heidi Storgaard, Amra Alibegovic, Stine Jacobsen, Emma Nilsson, Arne Astrup, Bjørn Quistorff, and Allan Vaag

Mitochondrial Function in Skeletal Muscle Is Normal and Unrelated to Insulin Action in Young Men Born with Low Birth Weight
J Clin Endocrinol Metab 2008 93: 3885-3892; first published July 15 2008 as doi:10.1210/jc.2008-0630 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Mitochondrial dysfunction is not an early defect preceding insulin resistance in young men with low birth weight.

Daniel-Henri Manicourt and Jean-Pierre Devogelaer

Urban Tropospheric Ozone Increases the Prevalence of Vitamin D Deficiency among Belgian Postmenopausal Women with Outdoor Activities during Summer
J Clin Endocrinol Metab 2008 93: 3893-3899; first published July 15 2008 as doi:10.1210/jc.2007-2663 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
This cross-sectional study of healthy community-dwelling postmenopausal women with similar body mass indices and vitamin-D intakes, but exposed to different levels of tropospheric ozone levels, suggests that air pollution might be a neglected risk factor for vitamin-D deficiency.

K. Mai, T. Bobbert, F. Reinecke, J. Andres, C. Maser-Gluth, S. A. Wudy, M. Möhlig, M. O. Weickert, M. F. Hartmann, H. M. Schulte, S. Diederich, A. F. H. Pfeiffer, and J. Spranger

Intravenous Lipid and Heparin Infusion-Induced Elevation in Free Fatty Acids and Triglycerides Modifies Circulating Androgen Levels in Women: A Randomized, Controlled Trial
J Clin Endocrinol Metab 2008 93: 3900-3906; first published July 29 2008 as doi:10.1210/jc.2008-0714 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In young healthy women, intravenous lipid/heparin infusion increases circulating androgens by reduction of urinary excretion of androgen metabolites, suggesting that elevated free fatty acids might contribute to the development of hyperandrogenism in women with polycystic ovary syndrome.

Connie M. Weaver, Linda D. McCabe, George P. McCabe, Michelle Braun, Berdine R. Martin, Linda A. DiMeglio, and Munro Peacock

Vitamin D Status and Calcium Metabolism in Adolescent Black and White Girls on a Range of Controlled Calcium Intakes
J Clin Endocrinol Metab 2008 93: 3907-3914; first published August 5 2008 as doi:10.1210/jc.2008-0645 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Calcium intake and race, but not vitamin D status, contribute to differences in calcium absorption and retention between adolescent black and white girls.

Peter Elfström, Scott M. Montgomery, Olle Kämpe, Anders Ekbom, and Jonas F. Ludvigsson

Risk of Thyroid Disease in Individuals with Celiac Disease
J Clin Endocrinol Metab 2008 93: 3915-3921; first published July 8 2008 as doi:10.1210/jc.2008-0798 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Pathogenesis, epidemiology, and clinical manifestations of celiac disease in adults]
Celiac disease was associated with increased risk of hypothyroidism, thyroiditis, and hyperthyroidism in a population-based cohort study of 14,000 individuals.

F. Galletti, L. D'Elia, G. Barba, A. Siani, F. P. Cappuccio, E. Farinaro, R. Iacone, O. Russo, D. De Palma, R. Ippolito, and P. Strazzullo

High-Circulating Leptin Levels Are Associated with Greater Risk of Hypertension in Men Independently of Body Mass and Insulin Resistance: Results of an Eight-Year Follow-Up Study
J Clin Endocrinol Metab 2008 93: 3922-3926; first published August 5 2008 as doi:10.1210/jc.2008-1280 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In normotensive men, an elevated circulating leptin level is a significant predictor of the risk to develop hypertension, independently of body mass index and insulin resistance.

Stefan Pilz, Winfried März, Britta Wellnitz, Ursula Seelhorst, Astrid Fahrleitner-Pammer, Hans P. Dimai, Bernhard O. Boehm, and Harald Dobnig

Association of Vitamin D Deficiency with Heart Failure and Sudden Cardiac Death in a Large Cross-Sectional Study of Patients Referred for Coronary Angiography
J Clin Endocrinol Metab 2008 93: 3927-3935; first published August 5 2008 as doi:10.1210/jc.2008-0784 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Low levels of 25-hydroxyvitamin D and 1,25-dihyrdoxyvitamin D are associated with prevalent myocardial dysfunction and deaths dues due to heart failure and sudden cardiac death. Maintenance of an optimal vitamin D status may be a promising approach for myocardial disease treatment and prevention.

Molly M. Lamb, Xiang Yin, Katherine Barriga, Michelle R. Hoffman, Anna E. Barón, George S. Eisenbarth, Marian Rewers, and Jill M. Norris

Dietary Glycemic Index, Development of Islet Autoimmunity, and Subsequent Progression to Type 1 Diabetes in Young Children
J Clin Endocrinol Metab 2008 93: 3936-3942; first published August 5 2008 as doi:10.1210/jc.2008-0886 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
In 1,776 children at increased risk for type 1 diabetes, higher dietary glycemic index is not associated with development of islet autoimmunity, but with more rapid progression from islet autoimmunity to type 1 diabetes, perhaps due to increased demand on the {beta}-cell to release insulin.

Rossella Elisei, Clara Ugolini, David Viola, Cristiana Lupi, Agnese Biagini, Riccardo Giannini, Cristina Romei, Paolo Miccoli, Aldo Pinchera, and Fulvio Basolo

BRAF^V600E Mutation and Outcome of Patients with Papillary Thyroid Carcinoma: A 15-Year Median Follow-Up Study
J Clin Endocrinol Metab 2008 93: 3943-3949; first published August 5 2008 as doi:10.1210/jc.2008-0607 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Compared to other papillary thyroid cancer patients, those displaying the BRAFV600E mutation have a worse outcome in terms of persistent disease and lower survival.

Marco Capezzone, Silvia Cantara, Stefania Marchisotta, Sebastiano Filetti, Maria Margherita De Santi, Benedetta Rossi, Giuseppe Ronga, Cosimo Durante, and Furio Pacini

Short Telomeres, Telomerase Reverse Transcriptase Gene Amplification, and Increased Telomerase Activity in the Blood of Familial Papillary Thyroid Cancer Patients
J Clin Endocrinol Metab 2008 93: 3950-3957; first published July 29 2008 as doi:10.1210/jc.2008-0372 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Patients with familial papillary thyroid cancer display an imbalance of the telomere-telomerase complex in the peripheral blood, characterized by short telomeres and hTERT gene amplification and expression. These features may be a marker and implicated in the inherited predisposition to develop the disease.

MaryFran R. Sowers, Huiyong Zheng, Daniel McConnell, Bin Nan, Sioban Harlow, and John F. Randolph, Jr.

Follicle Stimulating Hormone and Its Rate of Change in Defining Menopause Transition Stages
J Clin Endocrinol Metab 2008 93: 3958-3964; first published July 22 2008 as doi:10.1210/jc.2008-0482 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Four major FSH stages and their characteristics are identified in a longitudinal study of 629 women who were assessed annually from their late reproductive years into the postmenopause.

Carl A. Anderson, Gu Zhu, Mario Falchi, Stéphanie M. van den Berg, Susan A. Treloar, Timothy D. Spector, Nicholas G. Martin, Dorret I. Boomsma, Peter M. Visscher, and Grant W. Montgomery

A Genome-Wide Linkage Scan for Age at Menarche in Three Populations of European Descent
J Clin Endocrinol Metab 2008 93: 3965-3970; first published July 22 2008 as doi:10.1210/jc.2007-2568 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
A genome-wide linkage screen in Australian, Dutch, and British populations(for loci influencing variation in age-at-menarche finds a possible region on chromosome 12q.

Pierre Bougnères, Letitia Pantalone, Agnès Linglart, Anya Rothenbühler, and Catherine Le Stunff

Endocrine Manifestations of the Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neural Tumor Syndrome in Childhood
J Clin Endocrinol Metab 2008 93: 3971-3980; first published July 15 2008 as doi:10.1210/jc.2008-0238 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Various types of hypothalamic-pituitary endocrine dysfunction are associated with rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndromes. These possibilities should be considered in all patients with isolated, rapid, and early obesity.

Steen J. Bonnema, Viveque E. Nielsen, Henrik Boel-Jørgensen, Peter Grupe, Peter B. Andersen, Lars Bastholt, and Laszlo Hegedüs

BRIEF REPORT:Recombinant Human Thyrotropin-Stimulated Radioiodine Therapy of Large Nodular Goiters Facilitates Tracheal Decompression and Improves Inspiration
J Clin Endocrinol Metab 2008 93: 3981-3984; first published July 29 2008 as doi:10.1210/jc.2008-0485 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In patients with a large compressive goiter, recombinant thyrotropin stimulated 131I therapy significantly facilitates tracheal decompression and improves inspiration without increasing the risk of acute upper airway obstruction.

Mario Rotondi, Carlo Cappelli, Barbara Pirali, Ilenia Pirola, Flavia Magri, Rodolfo Fonte, Maurizio Castellano, Enrico Agabiti Rosei, and Luca Chiovato

BRIEF REPORT:The Effect of Pregnancy on Subsequent Relapse from Graves’ Disease after a Successful Course of Antithyroid Drug Therapy
J Clin Endocrinol Metab 2008 93: 3985-3988; first published July 29 2008 as doi:10.1210/jc.2008-0966 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Diagnosis and treatment of hyperthyroidism during pregnancy]
A significantly higher rate of relapsing Graves' hyperthyroidism is found in patients who became pregnant after stopping anti-thyroid drug treatment, as opposed to patients who did not.

Francesco D'Aiuto, Wael Sabbah, Gopalakrishnan Netuveli, Nikos Donos, Aroon D. Hingorani, John Deanfield, and Georgios Tsakos

BRIEF REPORT:Association of the Metabolic Syndrome with Severe Periodontitis in a Large U.S. Population-Based Survey
J Clin Endocrinol Metab 2008 93: 3989-3994; first published August 5 2008 as doi:10.1210/jc.2007-2522 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
A large U.S. population-based survey reveals a link between diagnosis of severe periodontitis with the metabolic syndrome and most of its components. These data suggest that improvements in oral-gingival health might influence cardio-metabolic traits and the risk of the metabolic syndrome.

Mark Ellrichmann, Mario Kapelle, Peter R. Ritter, Jens J. Holst, Karl-Heinz Herzig, Wolfgang E. Schmidt, Frank Schmitz, and Juris J. Meier

BRIEF REPORT:Orlistat Inhibition of Intestinal Lipase Acutely Increases Appetite and Attenuates Postprandial Glucagon-Like Peptide-1-(7–36)-Amide-1, Cholecystokinin, and Peptide YY Concentrations
J Clin Endocrinol Metab 2008 93: 3995-3998; first published July 22 2008 as doi:10.1210/jc.2008-0924 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Orlistat accelerates gastric emptying and markedly reduces the postprandial secretion of the anorexigenic hormones glucagon-like peptide-1, peptide YY, and cholecystokinin. However, these alterations in gastrointestinal hormone concentrations may increase appetite and food consumption, and should be considered when using lipase inhibitors for the treatment of morbid obesity.

Endocrine Research:

Anne Lene Dalkjær Riis, Jens Otto Lunde Jørgensen, Per Ivarsen, Jan Frystyk, Jørgen Weeke, and Niels Møller

Increased Protein Turnover and Proteolysis Is an Early and Primary Feature of Short-Term Experimental Hyperthyroidism in Healthy Women
J Clin Endocrinol Metab 2008 93: 3999-4005; first published July 15 2008 as doi:10.1210/jc.2008-0550 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Mild short-term experimental hyperthyroidism increases whole body protein turnover and breakdown before any measurable changes in energy expenditure, glucose, and fat metabolism, suggesting that amino acid and protein metabolism is an early and primary target for thyroid hormone action in humans.

Eric R. Hugo, Dana C. Borcherding, Keith S. Gersin, Jean Loftus, and Nira Ben-Jonathan

Prolactin Release by Adipose Explants, Primary Adipocytes, and LS14 Adipocytes
J Clin Endocrinol Metab 2008 93: 4006-4012; first published July 22 2008 as doi:10.1210/jc.2008-1172 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
The release of prolactin from subcutaneous and visceral adipose explants and mature adipocytes, the effects of obesity, and the regulation of prolactin secretion by insulin and selected cytokines is discussed.

Lise Wegner, Meena S. Hussain, Kasper Pilgaard, Torben Hansen, Oluf Pedersen, Allan Vaag, and Pernille Poulsen

Impact of TCF7L2 rs7903146 on Insulin Secretion and Action in Young and Elderly Danish Twins
J Clin Endocrinol Metab 2008 93: 4013-4019; first published July 8 2008 as doi:10.1210/jc.2008-0855 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
The transcription factor 7-like 2 (TCF7L2) rs7903146 T-allele associates with hepatic insulin resistance and diminishes glucose-stimulated plasma insulin secretion in Danish twins. There is no evidence of a role of TCF7L2 gene expression in the regulation of glucose homeostasis in subcutaneous fat or muscle.

Petra Kok, Remberto C. Paulo, Mihaela Cosma, Kristi L. Mielke, John M. Miles, Cyril Y. Bowers, and Johannes D. Veldhuis

Estrogen Supplementation Selectively Enhances Hypothalamo-Pituitary Sensitivity to Ghrelin in Postmenopausal Women
J Clin Endocrinol Metab 2008 93: 4020-4026; first published July 8 2008 as doi:10.1210/jc.2008-0522 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Transdermal estradiol supplementation augments hypothalamo-pituitary sensitivity to physiological amounts of acylated ghrelin in postmenopausal women, a finding that may help devise novel secretagogues to obviate hyposomatotropism with aging and hypogonadal individuals.

Jacques Beltrand, Rasa Verkauskiene, Ramona Nicolescu, Oliver Sibony, Pascal Gaucherand, Didier Chevenne, Olivier Claris, and Claire Lévy-Marchal

Adaptive Changes in Neonatal Hormonal and Metabolic Profiles Induced by Fetal Growth Restriction
J Clin Endocrinol Metab 2008 93: 4027-4032; first published August 5 2008 as doi:10.1210/jc.2008-0562 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Fetal growth restriction induces changes in body composition and metabolism suggestive of a higher insulin sensitivity independently from birth weight itself, reflecting adaptive changes to an adverse fetal environment, thus leading to understanding the association between low birth weight and the risk of type 2 diabetes later in life.

A. L. Utz, A. Yamamoto, P. Sluss, J. Breu, and K. K. Miller

Androgens May Mediate a Relative Preservation of IGF-I Levels in Overweight and Obese Women Despite Reduced Growth Hormone Secretion
J Clin Endocrinol Metab 2008 93: 4033-4040; first published July 22 2008 as doi:10.1210/jc.2008-0930 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Despite a linear decrease in GH secretion and peak stimulated GH levels with increasing body mass index in healthy overweight and obese women, IGF-I levels are not commensurately reduced. Androgens may contribute to this relative preservation of IGF-I secretion despite reduced GH secretion.

Karl Michaëlsson, Lars Lind, Jan Frystyk, Allan Flyvbjerg, Rolf Gedeborg, Christian Berne, Björn Zethelius, Hans Mallmin, Stefan Söderberg, and Håkan Melhus

Serum Adiponectin in Elderly Men Does Not Correlate with Fracture Risk
J Clin Endocrinol Metab 2008 93: 4041-4047; first published July 22 2008 as doi:10.1210/jc.2008-0617 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Although higher adiponectin levels are associated with a decrease in bone mineral density in the elderly, these levels have no relation to fracture risk in men.

Katrine Bay, Arieh S. Cohen, Finn Stener Jørgensen, Connie Jørgensen, Anne Marie Lind, Niels E. Skakkebæk, and Anna-Maria Andersson

Insulin-Like Factor 3 Levels in Second-Trimester Amniotic Fluid
J Clin Endocrinol Metab 2008 93: 4048-4051; first published July 8 2008 as doi:10.1210/jc.2008-0358 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Leydig cell hormone insulin-like factor 3 (INSL3) is present in amniotic fluid surrounding male, but not female fetuses in second trimester, supporting the hypothesis that this hormone is essential for testicular descent.

Ferdinand Roelfsema, Alberto M. Pereira, Daniel M. Keenan, Johannes D. Veldhuis, and Johannes A. Romijn

Thyrotropin Secretion by Thyrotropinomas Is Characterized by Increased Pulse Frequency, Delayed Diurnal Rhythm, Enhanced Basal Secretion, Spikiness, and Disorderliness
J Clin Endocrinol Metab 2008 93: 4052-4057; first published August 5 2008 as doi:10.1210/jc.2008-1145 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Serum TSH secretion profiles in five thyrotropinoma patients are described. As in other pituitary tumors, secretion was characterized by increased pulsatility, basal release, reduced pattern regularity, and phase shifting of the diurnal rhythm. These features imply altered properties of the thyrotrope and (partial) loss of cell-cell communication.

Rebecca S. Usadi, Jeremy M. Groll, Bruce A. Lessey, Ruth A. Lininger, Richard J. Zaino, Marc A. Fritz, and Steven L. Young

Endometrial Development and Function in Experimentally Induced Luteal Phase Deficiency
J Clin Endocrinol Metab 2008 93: 4058-4064; first published July 22 2008 as doi:10.1210/jc.2008-0460 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In an experimental model of luteal phase deficiency evaluating the effect of subphysiologic progesterone concentrations on the endometrium, western analysis shows that some proteins' concentrations may be affected by low serum progesterone.

Marianne Böni-Schnetzler, Jeffrey Thorne, Géraldine Parnaud, Lorella Marselli, Jan A. Ehses, Julie Kerr-Conte, Francois Pattou, Philippe A. Halban, Gordon C. Weir, and Marc Y. Donath

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation
J Clin Endocrinol Metab 2008 93: 4065-4074; first published July 29 2008 as doi:10.1210/jc.2008-0396 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Pancreatic {beta}-cells obtained by laser capture microdissection from individuals with type 2 diabetes display elevated expression of the inflammatory cytokine interleukin (IL)-1{beta}. This elevation may be due to glucose-promoted IL-1{beta} auto-stimulation.

Carlos A. Aguilar-Salinas, Eduardo García García, Lorena Robles, Daniela Riaño, Doris Georgina Ruiz-Gomez, Ana Cristina García-Ulloa, Marco A. Melgarejo, Margarita Zamora, Luz E. Guillen-Pineda, Roopa Mehta, Samuel Canizales-Quinteros, Ma Teresa Tusie Luna, and Francisco J. Gómez-Pérez

High Adiponectin Concentrations Are Associated with the Metabolically Healthy Obese Phenotype
J Clin Endocrinol Metab 2008 93: 4075-4079; first published August 5 2008 as doi:10.1210/jc.2007-2724 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Certain obese individuals have adiponectin concentrations similar to those found in normal body weight subjects. This characteristic is independently associated with the metabolically healthy obese phenotype.

E. Ferretti, E. Tosi, A. Po, A. Scipioni, R. Morisi, M. S. Espinola, D. Russo, C. Durante, M. Schlumberger, I. Screpanti, S. Filetti, and A. Gulino

Notch Signaling Is Involved in Expression of Thyrocyte Differentiation Markers and Is Down-Regulated in Thyroid Tumors
J Clin Endocrinol Metab 2008 93: 4080-4087; first published July 29 2008 as doi:10.1210/jc.2008-0528 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Examination of the Notch pathway in normal and transformed thyroid follicular cells reveals their role in thyrocyte differentiation, pointing to a possible new therapeutic target in thyroid tumorigenesis.

Shahab Uddin, Abdul K. Siraj, Maha Al-Rasheed, Maqbool Ahmed, Rong Bu, Jeffrey N. Myers, Abdulrahman Al-Nuaim, Saif Al-Sobhi, Fouad Al-Dayel, Prashant Bavi, Azhar R. Hussain, and Khawla S. Al-Kuraya

Fatty Acid Synthase and AKT Pathway Signaling in a Subset of Papillary Thyroid Cancers
J Clin Endocrinol Metab 2008 93: 4088-4097; first published August 5 2008 as doi:10.1210/jc.2008-0503 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
A tight, functional association between fatty acid synthase and PI3K/AKT is seen in a subset of papillary thyroid carcinoma cells, suggesting a potentially new therapeutic target for this disease.

Marie Maumus, Coralie Sengenès, Pauline Decaunes, Alexia Zakaroff-Girard, Virginie Bourlier, Max Lafontan, Jean Galitzky, and Anne Bouloumié

Evidence of in Situ Proliferation of Adult Adipose Tissue-Derived Progenitor Cells: Influence of Fat Mass Microenvironment and Growth
J Clin Endocrinol Metab 2008 93: 4098-4106; first published August 5 2008 as doi:10.1210/jc.2008-0044 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Adipose tissue-derived progenitor cells exhibit proliferative activity in vivo, which is modulated by the body mass index. The microenvironment in which the progenitor cells reside (cell partners and their secretory products as well as hypoxia) may play a central role in the control of their self-renewal.

Jie Xiang, Xiao-Ying Li, Min Xu, Jie Hong, Yun Huang, Jiao-Rong Tan, Xi Lu, Meng Dai, Bing Yu, and Guang Ning

Zinc Transporter-8 Gene (SLC30A8) Is Associated with Type 2 Diabetes in Chinese
J Clin Endocrinol Metab 2008 93: 4107-4112; first published July 15 2008 as doi:10.1210/jc.2008-0161 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
The gene variant of SLC30A8, rs13266634, is associated with type 2 diabetes in Chinese and with acute insulin response to glucose and the glucose disposition index.

Ana Paula Abreu, Ericka Barbosa Trarbach, Margaret de Castro, Elaine Maria Frade Costa, Beatriz Versiani, Maria Tereza Matias Baptista, Heraldo Mendes Garmes, Berenice Bilharinho Mendonca, and Ana Claudia Latronico

Loss-of-Function Mutations in the Genes Encoding Prokineticin-2 or Prokineticin Receptor-2 Cause Autosomal Recessive Kallmann Syndrome
J Clin Endocrinol Metab 2008 93: 4113-4118; first published August 5 2008 as doi:10.1210/jc.2008-0958 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
The repertoire of homozygous loss-of-function mutations of prokineticin and its receptor, PROK2 and PROKR2, is expanded in patients with hypogonadotropic hypogonadism. Heterozygous deleterious mutations involving these genes are not sufficient to cause this phenotype.

Roger Gejman, Dalia L. Batista, Ying Zhong, Yunli Zhou, Xun Zhang, Brooke Swearingen, Constantine A. Stratakis, E. Tessa Hedley-Whyte, and Anne Klibanski

Selective Loss of MEG3 Expression and Intergenic Differentially Methylated Region Hypermethylation in the MEG3/DLK1 Locus in Human Clinically Nonfunctioning Pituitary Adenomas
J Clin Endocrinol Metab 2008 93: 4119-4125; first published July 15 2008 as doi:10.1210/jc.2007-2633 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Loss of expression of the maternally imprinted gene MEG3 in clinically non-functioning pituitary adenomas may play a tumorigenic role.

Chrystel M. Pretto, Héloïse P. Gaide Chevronnay, Patricia B. Cornet, Christine Galant, Denis Delvaux, Pierre J. Courtoy, Etienne Marbaix, and Patrick Henriet

Production of Interleukin-1 by Human Endometrial Stromal Cells Is Triggered during Menses and Dysfunctional Bleeding and Is Induced in Culture by Epithelial Interleukin-1 Released upon Ovarian Steroids Withdrawal
J Clin Endocrinol Metab 2008 93: 4126-4134; first published July 15 2008 as doi:10.1210/jc.2007-2636 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
A loop of interleukin (IL)-1{alpha} expression by resident stromal cells amplifies the paracrine induction of stromal matrix metalloproteinase-1 by epithelial-derived IL-1{alpha} in the degradation of endometrium during menstruation and dysfunctional bleeding. Ovarian steroids control the release of epithelial IL-1{alpha} and the synthesis of stromal IL-1{alpha}, respectively.

Sébastien Gaujoux, Frédérique Tissier, Lionel Groussin, Rossella Libé, Bruno Ragazzon, Pierre Launay, Anne Audebourg, Bertrand Dousset, Xavier Bertagna, and Jérôme Bertherat

BRIEF REPORT:Wnt/β-Catenin and 3',5'-Cyclic Adenosine 5'-Monophosphate/Protein Kinase A Signaling Pathways Alterations and Somatic β-Catenin Gene Mutations in the Progression of Adrenocortical Tumors
J Clin Endocrinol Metab 2008 93: 4135-4140; first published July 22 2008 as doi:10.1210/jc.2008-0631 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
The Wnt/{beta}-catenin pathway is activated in primary pigmented nodular adrenocortical diseases and adrenocortical adenomas with PRKAR1A mutations, suggesting a cross-talk between the cAMP and the Wnt/{beta}-catenin pathways in adrenocortical tumor development. In addition, the occurrence of an additional hit of a CTNNB1 somatic mutation is associated with larger or more aggressive adrenocortical tumors.

Ana Karina M. B. Sodré, Ileana G. S. Rubio, Ana Luiza R. Galrão, Meyer Knobel, Eduardo K. Tomimori, Venâncio A. F. Alves, Cristina T. Kanamura, Carlos A. Buchpiguel, Tomoco Watanabe, Celso U. M. Friguglietti, Marco A. V. Kulcsar, Geraldo Medeiros-Neto, and Rosalinda Y. A. Camargo

BRIEF REPORT:Association of Low Sodium-Iodide Symporter Messenger Ribonucleic Acid Expression in Malignant Thyroid Nodules with Increased Intracellular Protein Staining
J Clin Endocrinol Metab 2008 93: 4141-4145; first published July 15 2008 as doi:10.1210/jc.2007-0353 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
In malignant thyroid nodules, low sodium-iodide symporter (NIS) mRNA expression was associated with strong intracellular NIS protein staining, probably relating to the NIS protein's inability to migrate to the plasma membrane and to the low iodide uptake seen in malignant tumor cells.

Marianthi Georgitsi, Elina Heliövaara, Ralf Paschke, Ajith V. K. Kumar, Marc Tischkowitz, Outi Vierimaa, Pasi Salmela, Timo Sane, Ernesto De Menis, Salvatore Cannavò, Sadi Gündogdu, Anneke Lucassen, Louise Izatt, Simon Aylwin, Gul Bano, Shirley Hodgson, Christian A. Koch, Auli Karhu, and Lauri A. Aaltonen

BRIEF REPORT:Large Genomic Deletions in AIP in Pituitary Adenoma Predisposition
J Clin Endocrinol Metab 2008 93: 4146-4151; first published July 15 2008 as doi:10.1210/jc.2008-1003 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  
Large genomic deletions of the aryl hydrocarbon receptor interacting protein gene (AIP) account for a subset of pituitary adenoma predisposition, implying that multiplex ligation-dependent probe amplification could be considered if direct sequencing does not identify a mutation.

Peyman Björklund, Tijana Krajisnik, Göran Åkerström, Gunnar Westin, and Tobias E. Larsson

BRIEF REPORT:Type I Membrane Klotho Expression Is Decreased and Inversely Correlated to Serum Calcium in Primary Hyperparathyroidism
J Clin Endocrinol Metab 2008 93: 4152-4157; first published August 5 2008 as doi:10.1210/jc.2008-0564 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Parathyroid Klotho expression is decreased and inversely associated with serum calcium in patients with primary hyperparathyroidism, providing novel insights into the regulatory mechanisms of Klotho expression and abnormal PTH secretion in this disease.

Edwin A. Garcia, Barbara Heude, Clive J. Petry, Maria Gueorguiev, Zaki K. Hassan-Smith, Antigoni Spanou, Susan M. Ring, David B. Dunger, Nicholas Wareham, Manjinder S. Sandhu, Ken K. Ong, and Márta Korbonits

BRIEF REPORT:Ghrelin Receptor Gene Polymorphisms and Body Size in Children and Adults
J Clin Endocrinol Metab 2008 93: 4158-4161; first published July 22 2008 as doi:10.1210/jc.2008-0366 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  
Haplotype-tagging single nucleotide polymorphisms representing common variations in the ghrelin receptor/growth hormone secretagogue receptor gene (GHSR) are not associated with body weight or height, or BMI in population-based cohorts comprised of 5,807 adults and 843 children.

Announcements and Resources:

International Society for Clinical Densitometry Annual Meeting
J Clin Endocrinol Metab 2008 93: 3670 [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2008 93: 4162 [Full Text] [PDF]  

Endocrine-Related Resources from the National Institutes of Health
J Clin Endocrinol Metab 2008 93: 4163-4166 [Full Text] [PDF]  

National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available
J Clin Endocrinol Metab 2008 93: 4167-4169 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Scott Grundy and Robert Vigersky

Patient Information Page from The Hormone Foundation:The Hormone Foundation’s Patient Guide on Metabolic Risk: Primary Prevention of Cardiovascular Disease and Type 2 Diabetes
J Clin Endocrinol Metab 2008 93 [Full Text] [PDF]  

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