The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-18a [Full Text] [PDF]  

Special Features:

Philip Zeitler

UPDATE:Update on Nonautoimmune Diabetes in Children
J Clin Endocrinol Metab 2009 94: 2215-2220 , doi:10.1210/jc.2009-0493 [Abstract] [Full Text] [PDF]  
Despite the increasing prevalence of non-autoimmune diabetes in adolescents, knowledge regarding the diagnosis, treatment, and long-term complications of the disorder is just beginning to emerge.

Ritika R. Kapoor, Chela James, Sarah E. Flanagan, Sian Ellard, Simon Eaton, and Khalid Hussain

CLINICAL CASE SEMINAR:3-Hydroxyacyl-Coenzyme A Dehydrogenase Deficiency and Hyperinsulinemic Hypoglycemia: Characterization of a Novel Mutation and Severe Dietary Protein Sensitivity
J Clin Endocrinol Metab 2009 94: 2221-2225 , doi:10.1210/jc.2009-0423 [Abstract] [Full Text] [PDF]  
Hyperinsulinemic hypoglycemia due to HADH mutations is associated with acute dietary protein sensitivity and a normal acylcarnitine profile.

Elizabeth A. Lawson, Xun Zhang, Jonathan T. Crocker, Wei-Lien Wang, and Anne Klibanski

CLINICAL CASE SEMINAR:Hypoglycemia from IGF2 Overexpression Associated with Activation of Fetal Promoters and Loss of Imprinting in a Metastatic Hemangiopericytoma
J Clin Endocrinol Metab 2009 94: 2226-2231 , doi:10.1210/jc.2009-0153 [Abstract] [Full Text] [PDF]  
IGF-2 overexpression associated with activation of fetal promoters and loss of imprinting in a case of non-islet-cell tumor hypoglycemia due to metastatic hemangiopericytoma.

Irl B. Hirsch

CLINICAL REVIEW:Realistic Expectations and Practical Use of Continuous Glucose Monitoring for the Endocrinologist
J Clin Endocrinol Metab 2009 94: 2232-2238 , doi:10.1210/jc.2008-2625 [Abstract] [Full Text] [PDF]  
Although still in its infancy, and despite challenges with accuracy and expense, continuous glucose monitoring is becoming an important tool for the treatment of diabetes.

Hans Henrik Thodberg

CLINICAL REVIEW:An Automated Method for Determination of Bone Age
J Clin Endocrinol Metab 2009 94: 2239-2244 , doi:10.1210/jc.2008-2474 [Abstract] [Full Text] [PDF] [Supplemental Data]  
After more than 20 years of development, automated bone age determination now seems to be mature for clinical use.

Mark I. McCarthy

COMMENTARY:What Will Genome-Wide Association Studies Mean to the Clinical Endocrinologist?
J Clin Endocrinol Metab 2009 94: 2245-2246 , doi:10.1210/jc.2009-0403 [Full Text] [PDF]  

Editorials:

Anne Klibanski

EDITORIAL:Dopamine Agonist Therapy in Prolactinomas: When Can Treatment Be Discontinued?
J Clin Endocrinol Metab 2009 94: 2247-2249 doi:10.1210/jc.2009-0999 [Full Text] [PDF]  

Sarah L. Berga

EDITORIAL:Polycystic Ovary Syndrome: A Model of Combinatorial Endocrinology?
J Clin Endocrinol Metab 2009 94: 2250-2251 doi:10.1210/jc.2009-0959 [Full Text] [PDF]  

James M. Roberts and Augustine Rajakumar

EDITORIAL:Preeclampsia and Soluble fms-Like Tyrosine Kinase 1
J Clin Endocrinol Metab 2009 94: 2252-2254 doi:10.1210/jc.2009-0945 [Full Text] [PDF]  

Endocrine Care:

Jens Bollerslev, Thord Rosen, Charlotte L. Mollerup, Jörgen Nordenström, Marek Baranowski, Celina Franco, Ylva Pernow, Gunhild A. Isaksen, Kristin Godang, Thor Ueland, Svante Jansson on behalf of the SIPH Study Group

Effect of Surgery on Cardiovascular Risk Factors in Mild Primary Hyperparathyroidism
J Clin Endocrinol Metab 2009 94: 2255-2261 , doi:10.1210/jc.2008-2742 [Abstract] [Full Text] [PDF]  
In a 2-year perspective, surgery has no beneficial effect compared to observation on a panel of cardiovascular risk factors in mild primary hyperparathyroidism.

Harry J. Hirsch, Talia Eldar-Geva, Fortu Benarroch, Orit Rubinstein, and Varda Gross-Tsur

Primary Testicular Dysfunction Is a Major Contributor to Abnormal Pubertal Development in Males with Prader-Willi Syndrome
J Clin Endocrinol Metab 2009 94: 2262-2268 , doi:10.1210/jc.2008-2760 [Abstract] [Full Text] [PDF]  
Primary testicular dysfunction, which is characterized by normal anti-Müllerian hormone, low inhibin B, and elevated FSH, is a major contributor to hypogonadism in males with Prader-Willi syndrome.

Maria Felicia Faienza, Giacomina Brunetti, Silvia Colucci, Laura Piacente, Maria Ciccarelli, Lucia Giordani, Giovanni Carlo Del Vecchio, Massimo D'Amore, Livia Albanese, Luciano Cavallo, and Maria Grano

Osteoclastogenesis in Children with 21-Hydroxylase Deficiency on Long-Term Glucocorticoid Therapy: The Role of Receptor Activator of Nuclear Factor-B Ligand/Osteoprotegerin Imbalance
J Clin Endocrinol Metab 2009 94: 2269-2276 , doi:10.1210/jc.2008-2446 [Abstract] [Full Text] [PDF]  
Spontaneous osteoclastogenesis occurs in 21-OHD patients on long-term glucocorticoid treatment, supported both by the presence of osteoclast precursors and factors released by T-cells.

Vaishali B. Popat, Karim A. Calis, Vien H. Vanderhoof, Giovanni Cizza, James C. Reynolds, Nancy Sebring, James F. Troendle, and Lawrence M. Nelson

Bone Mineral Density in Estrogen-Deficient Young Women
J Clin Endocrinol Metab 2009 94: 2277-2283 , doi:10.1210/jc.2008-1878 [Abstract] [Full Text] [PDF]  
Factors significantly associated with lower bone density in estrogen-deficient young women include delay in diagnosis, menstrual irregularity before age 20, vitamin D insufficiency, lack of exercise, and non-compliance with hormone replacement therapy.

M. Bolognese, J. H. Krege, W. H. Utian, R. Feldman, S. Broy, D. L. Meats, J. Alam, M. Lakshmanan, and M. Omizo

Effects of Arzoxifene on Bone Mineral Density and Endometrium in Postmenopausal Women with Normal or Low Bone Mass
J Clin Endocrinol Metab 2009 94: 2284-2289 , doi:10.1210/jc.2008-2143 [Abstract] [Full Text] [PDF]  
In postmenopausal women with normal to low bone mass, arzoxifene 20 mg/day increases bone mineral density at the spine and hip and has a neutral effect on the uterus and endometrium.

Katarina T. Borer, Elizabeth Wuorinen, Kimberly Ku, and Charles Burant

Appetite Responds to Changes in Meal Content, Whereas Ghrelin, Leptin, and Insulin Track Changes in Energy Availability
J Clin Endocrinol Metab 2009 94: 2290-2298 , doi:10.1210/jc.2008-2495 [Abstract] [Full Text] [PDF]  
Study results indicate that between meals, human appetite is influenced by signals generated by food passage through the mouth and the gastrointestinal tract, rather than by changes in energy availability, or in concentrations of ghrelin, leptin, and insulin.

Fitsum Guebre-Egziabher, Laurent Juillard, Yves Boirie, Martine Laville, Bernard Beaufrère, and Denis Fouque

Short-Term Administration of a Combination of Recombinant Growth Hormone and Insulin-Like Growth Factor-I Induces Anabolism in Maintenance Hemodialysis
J Clin Endocrinol Metab 2009 94: 2299-2305 , doi:10.1210/jc.2008-2262 [Abstract] [Full Text] [PDF]  
Unlike recombinant human IGF-1 (rhIGF-1) alone, a combined administration of moderate doses of rhGH plus rhIGF-1 in hemodialysis patients has an anabolic effect.

Edda Vignali, Giuseppe Viccica, Daniele Diacinti, Filomena Cetani, Luisella Cianferotti, Elena Ambrogini, Chiara Banti, Romano Del Fiacco, John P. Bilezikian, Aldo Pinchera, and Claudio Marcocci

Morphometric Vertebral Fractures in Postmenopausal Women with Primary Hyperparathyroidism
J Clin Endocrinol Metab 2009 94: 2306-2312 , doi:10.1210/jc.2008-2006 [Abstract] [Full Text] [PDF]  
Primary hyperparathyroidism is associated with an increased risk of morphometric vertebral fractures both in symptomatic and asymptomatic patients.

Vahid Mahabadi, John K. Amory, Ronald S. Swerdloff, William J. Bremner, Stephanie T. Page, Regine Sitruk-Ware, Peter D. Christensen, Narender Kumar, Yun-Yen Tsong, Diana Blithe, and Christina Wang

Combined Transdermal Testosterone Gel and the Progestin Nestorone Suppresses Serum Gonadotropins in Men
J Clin Endocrinol Metab 2009 94: 2313-2320 , doi:10.1210/jc.2008-2604 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Combined transdermal nestorone and testosterone gel demonstrated safe and effective suppression of gonadotropins, justifying a longer term study of this combination for suppression of spermatogenesis.

Kamal A. S. Al-Shoumer and Bagavathy A. Vasanthy

Serum Chromogranin A Concentration in Hyperthyroidism before and after Medical Treatment
J Clin Endocrinol Metab 2009 94: 2321-2324 , doi:10.1210/jc.2008-2231 [Abstract] [Full Text] [PDF]  
Untreated hyperthyroidism is associated with elevated CgA level that changes in parallel to thyroid status; therefore CgA concentration can be used as a potential marker of disease activity in hyperthyroidism.

Youri E. C. Taes, Bruno Lapauw, Griet Vanbillemont, Veerle Bogaert, Dirk De Bacquer, Hans Zmierczak, Stefan Goemaere, and Jean-Marc Kaufman

Fat Mass Is Negatively Associated with Cortical Bone Size in Young Healthy Male Siblings
J Clin Endocrinol Metab 2009 94: 2325-2331 , doi:10.1210/jc.2008-2501 [Abstract] [Full Text] [PDF]  
Increased fat mass is associated with smaller bone size, whereas lean mass is a consistent positive determinant of bone size.

Belinda J. Schouten, Penelope J. Hunt, John H. Livesey, Chris M. Frampton, and Steven G. Soule

FGF23 Elevation and Hypophosphatemia after Intravenous Iron Polymaltose: A Prospective Study
J Clin Endocrinol Metab 2009 94: 2332-2337 , doi:10.1210/jc.2008-2396 [Abstract] [Full Text] [PDF]  
Parenteral iron polymaltose causes prolonged hypophosphatemia, which is mediated by a rise in fibroblast growth factor 23.

Alicia A. Romano, Ken Dana, Bert Bakker, D. Aaron Davis, Joanne Julius Hunold, Joan Jacobs, and Barbara Lippe

Growth Response, Near-Adult Height, and Patterns of Growth and Puberty in Patients with Noonan Syndrome Treated with Growth Hormone
J Clin Endocrinol Metab 2009 94: 2338-2344 , doi:10.1210/jc.2008-2094 [Abstract] [Full Text] [PDF]  
Recombinant human (rh)GH significantly improves height SDS for children with Noonan syndrome at near adult height (NAH); duration of prepubertal rhGH and height SDS at puberty are important contributors to NAH.

Dieter Mesotten, Joost Wauters, Greet Van den Berghe, Pieter J. Wouters, Ilse Milants, and Alexander Wilmer

The Effect of Strict Blood Glucose Control on Biliary Sludge and Cholestasis in Critically Ill Patients
J Clin Endocrinol Metab 2009 94: 2345-2352 , doi:10.1210/jc.2008-2579 [Abstract] [Full Text] [PDF]  
Cholestatic liver dysfunction and biliary sludge are very common during prolonged critical illness, but are significantly reduced by intensive insulin therapy.

Bu B. Yeap, Zoë Hyde, Osvaldo P. Almeida, Paul E. Norman, S. A. Paul Chubb, Konrad Jamrozik, Leon Flicker, and Graeme J. Hankey

Lower Testosterone Levels Predict Incident Stroke and Transient Ischemic Attack in Older Men
J Clin Endocrinol Metab 2009 94: 2353-2359 , doi:10.1210/jc.2008-2416 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Lower testosterone levels are associated with increased incidence of stroke and transient ischemic attack in older men.

Susan K. Blank, Christopher R. McCartney, Sandhya Chhabra, Kristin D. Helm, Christine A. Eagleson, R. Jeffrey Chang, and John C. Marshall

Modulation of Gonadotropin-Releasing Hormone Pulse Generator Sensitivity to Progesterone Inhibition in Hyperandrogenic Adolescent Girls—Implications for Regulation of Pubertal Maturation
J Clin Endocrinol Metab 2009 94: 2360-2366 , doi:10.1210/jc.2008-2606 [Abstract] [Full Text] [PDF]  
Hyperandrogenism is variably associated with reduced GnRH pulse generator sensitivity to progesterone-mediated slowing during adolescence; insulin, in addition to androgens, may modulate progesterone sensitivity.

Juan Balasch, Francisco Fábregues, Francisco Carmona, Roser Casamitjana, and Manuel Tena-Sempere

Ovarian Luteinizing Hormone Priming Preceding Follicle-Stimulating Hormone Stimulation: Clinical and Endocrine Effects in Women with Long-Term Hypogonadotropic Hypogonadism
J Clin Endocrinol Metab 2009 94: 2367-2373 , doi:10.1210/jc.2009-0262 [Abstract] [Full Text] [PDF]  
Pretreatment with recombinant human (rh)LH/rhCG evokes unambiguous elevations in serum levels of endogenous LH during subsequent ovarian stimulation with rhFSH in hypogonadotropic hypogonadism patients with preserved pituitary function.

N. R. Biermasz, M. J. E. Wassenaar, A. A. van der Klaauw, A. M. Pereira, J. W. A. Smit, F. Roelfsema, R. Wolterbeek, H. M. Kroon, M. Kloppenburg, and J. A. Romijn

Pretreatment Insulin-Like Growth Factor-I Concentrations Predict Radiographic Osteoarthritis in Acromegalic Patients with Long-Term Cured Disease
J Clin Endocrinol Metab 2009 94: 2374-2379 , doi:10.1210/jc.2008-2393 [Abstract] [Full Text] [PDF]  
Pre-treatment IGF-I concentrations predict osteoarthritis in acromegaly.

Ann V. Schwartz, Patrick Garnero, Teresa A. Hillier, Deborah E. Sellmeyer, Elsa S. Strotmeyer, Kenneth R. Feingold, Helaine E. Resnick, Frances A. Tylavsky, Dennis M. Black, Steven R. Cummings, Tamara B. Harris, Douglas C. Bauer for the Health, Aging, and Body Composition Study

Pentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 2380-2386 , doi:10.1210/jc.2008-2498 [Abstract] [Full Text] [PDF]  
In older adults with type 2 diabetes, higher urine pentosidine is a risk factor for incident clinical fractures and prevalent vertebral fractures, independent of bone density.

Roderick F. A. de Lind van Wijngaarden, Koen F. M. Joosten, Sandra van den Berg, Barto J. Otten, Frank H. de Jong, C. G. J. (Fred) Sweep, Al W. de Weerd, and Anita C. S. Hokken-Koelega

The Relationship between Central Adrenal Insufficiency and Sleep-Related Breathing Disorders in Children with Prader-Willi Syndrome
J Clin Endocrinol Metab 2009 94: 2387-2393 , doi:10.1210/jc.2008-2808 [Abstract] [Full Text] [PDF]  
Sleep-related breathing worsens during metyrapon-induced stress in children with Prader-Willi syndrome; this worsening tends to be more severe in children with central adrenal insufficiency.

Rikke Nygaard Monrad, Louise Groth Grunnet, Eva Lind Rasmussen, Charlotte Malis, Allan Vaag, and Pernille Poulsen

Age-Dependent Nongenetic Influences of Birth Weight and Adult Body Fat on Insulin Sensitivity in Twins
J Clin Endocrinol Metab 2009 94: 2394-2399 , doi:10.1210/jc.2008-1858 [Abstract] [Full Text] [PDF]  
This report describes the age-dependent non-genetic influence of the fetal environment on insulin sensitivity, which is quantitatively similar to, and independent of, the effect of adult adiposity.

Charlotte Cerqueira, Nils Knudsen, Lars Ovesen, Hans Perrild, Lone B. Rasmussen, Peter Laurberg, and Torben Jørgensen

Association of Iodine Fortification with Incident Use of Antithyroid Medication—A Danish Nationwide Study
J Clin Endocrinol Metab 2009 94: 2400-2405 , doi:10.1210/jc.2009-0123 [Abstract] [Full Text] [PDF]  
Conservative iodine fortification causes only a modest and temporary increase in the incidence of hyperthyroidism as measured by use of anti-thyroid medication.

Estelle Louiset, Constantine A. Stratakis, Véronique Perraudin, Kurt J. Griffin, Rossella Libé, Sylvie Cabrol, Bruno Fève, Jacques Young, Lionel Groussin, Jérôme Bertherat, and Hervé Lefebvre

The Paradoxical Increase in Cortisol Secretion Induced by Dexamethasone in Primary Pigmented Nodular Adrenocortical Disease Involves a Glucocorticoid Receptor-Mediated Effect of Dexamethasone on Protein Kinase A Catalytic Subunits
J Clin Endocrinol Metab 2009 94: 2406-2413 , doi:10.1210/jc.2009-0031 [Abstract] [Full Text] [PDF]  
In adrenal tissues removed from patients with primary pigmented nodular adrenocortical disease, dexamethasone paradoxically stimulates cortisol secretion through activation of protein kinase A.

Anna Rapa, Alice Monzani, Stefania Moia, Daniela Vivenza, Simonetta Bellone, Antonella Petri, Francesca Teofoli, Alessandra Cassio, Graziano Cesaretti, Andrea Corrias, Vincenzo de Sanctis, Salvatore Di Maio, Cecilia Volta, Malgorzata Wasniewska, Luciano Tatò, and Gianni Bona

Subclinical Hypothyroidism in Children and Adolescents: A Wide Range of Clinical, Biochemical, and Genetic Factors Involved
J Clin Endocrinol Metab 2009 94: 2414-2420 , doi:10.1210/jc.2009-0375 [Abstract] [Full Text] [PDF]  
Overweight/obesity, thyroid hypoechogenicity, and non-synonymous mutations in the TSH-R gene are characterizing features of a large portion of children with subclinical hypothyroidism.

Steven A. Abrams, Penni D. Hicks, and Keli M. Hawthorne

Higher Serum 25-Hydroxyvitamin D Levels in School-Age Children Are Inconsistently Associated with Increased Calcium Absorption
J Clin Endocrinol Metab 2009 94: 2421-2427 , doi:10.1210/jc.2008-2587 [Abstract] [Full Text] [PDF] [Supplemental Data]  
There is no consistent pattern of relationship between the serum 25-hydroxyvitamin D concentration and calcium absorption in school-age children.

J. Kharlip, R. Salvatori, G. Yenokyan, and G. S. Wand

Recurrence of Hyperprolactinemia after Withdrawal of Long-Term Cabergoline Therapy
J Clin Endocrinol Metab 2009 94: 2428-2436 , doi:10.1210/jc.2008-2103 [Abstract] [Full Text] [PDF]  
Patients with substantial tumor reduction following 2 or more years of cabergoline therapy had a 63% risk of recurrent hyperprolactinemia 18 months after the treatment was stopped.

Norlela Sukor, Richard D. Gordon, Yee Kim Ku, Mark Jones, and Michael Stowasser

Role of Unilateral Adrenalectomy in Bilateral Primary Aldosteronism: A 22-Year Single Center Experience
J Clin Endocrinol Metab 2009 94: 2437-2445 , doi:10.1210/jc.2008-2803 [Abstract] [Full Text] [PDF]  
Unilateral adrenalectomy can be beneficial in some patients with apparent bilateral primary aldosteronism, and should not be dismissed as a treatment option.

Xiaosu Ma, Dorothy Becker, Vincent C. Arena, Paolo Vicini, and Carla Greenbaum

The Effect of Age on Insulin Sensitivity and Insulin Secretion in First-Degree Relatives of Type 1 Diabetic Patients: A Population Analysis
J Clin Endocrinol Metab 2009 94: 2446-2451 , doi:10.1210/jc.2008-2687 [Abstract] [Full Text] [PDF]  
β-cell function, adjusted for age-related insulin resistance, decreases throughout life in first-degree relatives, as indicated by analyses using population kinetics and minimal modeling of oral glucose tolerance test data.

Sven Gläser, Nele Friedrich, Ralf Ewert, Christoph Schäper, Matthias Nauck, Marcus Dörr, Henry Völzke, Stephan B. Felix, Alexander Krebs, Henri Wallaschofski, and Beate Koch

Association between Serum Insulin-Like Growth Factor (IGF) I and IGF Binding Protein-3 and Lung Function
J Clin Endocrinol Metab 2009 94: 2452-2458 , doi:10.1210/jc.2008-2662 [Abstract] [Full Text] [PDF]  
Insulin-like growth factor I (IGF-I) and IGF binding protein 3 are associated with higher lung volumes in men, and partly in women.

C. E. Higham, S. Rowles, D. Russell-Jones, A. M. Umpleby, and P. J. Trainer

Pegvisomant Improves Insulin Sensitivity and Reduces Overnight Free Fatty Acid Concentrations in Patients with Acromegaly
J Clin Endocrinol Metab 2009 94: 2459-2463 , doi:10.1210/jc.2008-2086 [Abstract] [Full Text] [PDF]  
This stable isotope study in acromegaly demonstrates improvement in insulin sensitivity of endogenous glucose production and glycerol Ra and a reduction in free fatty acid concentrations following pegvisomant.

Tine D. Clausen, Elisabeth R. Mathiesen, Torben Hansen, Oluf Pedersen, Dorte M. Jensen, Jeannet Lauenborg, Lone Schmidt, and Peter Damm

Overweight and the Metabolic Syndrome in Adult Offspring of Women with Diet-Treated Gestational Diabetes Mellitus or Type 1 Diabetes
J Clin Endocrinol Metab 2009 94: 2464-2470 , doi:10.1210/jc.2009-0305 [Abstract] [Full Text] [PDF]  
Intrauterine hyperglycemia may contribute to increased risk of overweight and the metabolic syndrome in adult offspring of mothers with diet-treated gestational diabetes mellitus or type 1 diabetes.

Tamara Wexler, Lindsay Gunnell, Zehra Omer, Karen Kuhlthau, Catherine Beauregard, Gwenda Graham, Andrea L. Utz, Beverly Biller, Lisa Nachtigall, Jay Loeffler, Brooke Swearingen, Anne Klibanski, and Karen K. Miller

Growth Hormone Deficiency Is Associated with Decreased Quality of Life in Patients with Prior Acromegaly
J Clin Endocrinol Metab 2009 94: 2471-2477 , doi:10.1210/jc.2008-2671 [Abstract] [Full Text] [PDF]  
Reduced quality of life is present in patients who develop growth hormone deficiency after cure of acromegaly compared to those who are GH-sufficient.

Anne-Mette Bay Bjørn, Anders Bojesen, Claus H. Gravholt, and Peter Laurberg

Hypothyroidism Secondary to Hypothalamic-Pituitary Dysfunction May Be Part of the Phenotype in Klinefelter Syndrome: A Case-Control Study
J Clin Endocrinol Metab 2009 94: 2478-2481 , doi:10.1210/jc.2009-0365 [Abstract] [Full Text] [PDF]  
Men with Klinefelter syndrome have low serum fT4 with no compensatory increase in serum TSH, possibly caused by a decrease in thyrothroph control of thyroid function.

Åsa Tivesten, Liesbeth Vandenput, Fernand Labrie, Magnus K. Karlsson, Östen Ljunggren, Dan Mellström, and Claes Ohlsson

Low Serum Testosterone and Estradiol Predict Mortality in Elderly Men
J Clin Endocrinol Metab 2009 94: 2482-2488 , doi:10.1210/jc.2008-2650 [Abstract] [Full Text] [PDF]  
Low testosterone and low estradiol may serve as markers of mortality risk in elderly men.

Kaylon L. Bruner-Tran, Kevin G. Osteen, and Antoni J. Duleba

Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model
J Clin Endocrinol Metab 2009 94: 2489-2494 , doi:10.1210/jc.2008-2802 [Abstract] [Full Text] [PDF]  
Simvastatin treatment reduces the risk of development of endometriosis in the nude mouse model in a dose-dependent fashion; furthermore, simvastatin decreases expression of matrix metalloproteinase-3 in cultures of human endometrial stroma.

Joel S. Finkelstein, Jason J. Wyland, Benjamin Z. Leder, Sherri-Ann M. Burnett-Bowie, Hang Lee, Harald Jüppner, and Robert M. Neer

Effects of Teriparatide Retreatment in Osteoporotic Men and Women
J Clin Endocrinol Metab 2009 94: 2495-2501 , doi:10.1210/jc.2009-0154 [Abstract] [Full Text] [PDF]  
The response to re-treatment with teriparatide, after a 2-year course of therapy and a 1-year hiatus, is clearly diminished.

Preamrudee Poomthavorn, Robyn Stargatt, and Margaret Zacharin

BRIEF REPORT:Psychosexual and Psychosocial Functions of Anorchid Young Adults
J Clin Endocrinol Metab 2009 94: 2502-2505 , doi:10.1210/jc.2008-1886 [Abstract] [Full Text] [PDF]  
A postnatal testosterone surge does not seem to be critical for male-typed sexual behaviors in men with anorchia when adolescent testosterone replacement has occurred.

Margrit Urbanek, Geetha Nampiaparampil, Janine D'Souza, Elizabeth Sefton, Christine Ackerman, Richard S. Legro, and Andrea Dunaif

BRIEF REPORT:The Role of Genetic Variation in the Lamin A/C Gene in the Etiology of Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 2665-2669 , doi:10.1210/jc.2008-2704 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genetic variants in lamin a/c are not common in Caucasian women with PCOS.

Endocrine Research:

Matthias Blüher, Nava Bashan, Iris Shai, Ilana Harman-Boehm, Tanya Tarnovscki, Eliezer Avinaoch, Michael Stumvoll, Arne Dietrich, Nora Klöting, and Assaf Rudich

Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity
J Clin Endocrinol Metab 2009 94: 2507-2515 , doi:10.1210/jc.2009-0002 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Obesity induces adipose tissue inflammation, which activates Ask1-mediated signaling in adipose tissue.

Akitoshi Tsuno, Kaei Nasu, Akitoshi Yuge, Harunobu Matsumoto, Masakazu Nishida, and Hisashi Narahara

Decidualization Attenuates the Contractility of Eutopic and Ectopic Endometrial Stromal Cells: Implications for Hormone Therapy of Endometriosis
J Clin Endocrinol Metab 2009 94: 2516-2523 , doi:10.1210/jc.2009-0207 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Decidualization attenuates the contractility of ectopic and eutopic endometrial stromal cells.

Christie P. Thomas, Janet I. Andrews, Nandita S. Raikwar, Elizabeth A. Kelley, Florian Herse, Ralf Dechend, Thaddeus G. Golos, and Kang Z. Liu

A Recently Evolved Novel Trophoblast-Enriched Secreted Form of fms-Like Tyrosine Kinase-1 Variant Is Up-Regulated in Hypoxia and Preeclampsia
J Clin Endocrinol Metab 2009 94: 2524-2530 , doi:10.1210/jc.2009-0017 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A primate-specific novel trophoblast-enriched sFlt1 variant is up-regulated in hypoxia and in preeclampsia, and may contribute to the pathophysiology of preeclampsia.

Dennis C. Y. Yeung, Karen S. L. Lam, Yu Wang, Annette W. K. Tso, and Aimin Xu

Serum Zinc-2-Glycoprotein Correlates with Adiposity, Triglycerides, and the Key Components of the Metabolic Syndrome in Chinese Subjects
J Clin Endocrinol Metab 2009 94: 2531-2536 , doi:10.1210/jc.2009-0058 [Abstract] [Full Text] [PDF]  
Elevated serum ZAG is closely associated with obesity and cardiovascular risk factors in Chinese subjects.

Susan G. Lakoski, Thomas A. Lagace, Jonathan C. Cohen, Jay D. Horton, and Helen H. Hobbs

Genetic and Metabolic Determinants of Plasma PCSK9 Levels
J Clin Endocrinol Metab 2009 94: 2537-2543 , doi:10.1210/jc.2009-0141 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Plasma levels of PCSK9 correlate with levels of low density lipoprotein-cholesterol (LDL-C), but account for only a small proportion of the variation in the LDL-C concentration.

Johannes D. Veldhuis and Cyril Y. Bowers

Factors Other than Sex Steroids Modulate GHRH and GHRP-2 Efficacies in Men: Evaluation Using a GnRH Agonist/Testosterone Clamp
J Clin Endocrinol Metab 2009 94: 2544-2550 , doi:10.1210/jc.2008-2767 [Abstract] [Full Text] [PDF] [Supplemental Data]  
During experimentally fixed sex-steroid availability, visceral fat contributes 41% of the GH-response variability to maximal GHRH drive, whereas IGF-I accounts for 31% of that for GHRP-2.

Tim J. Craig, Kenju Shimomura, Reinhard W. Holl, Sarah E. Flanagan, Sian Ellard, and Frances M. Ashcroft

An In-Frame Deletion in Kir6.2 (KCNJ11) Causing Neonatal Diabetes Reveals a Site of Interaction between Kir6.2 and SUR1
J Clin Endocrinol Metab 2009 94: 2551-2557 , doi:10.1210/jc.2009-0159 [Abstract] [Full Text] [PDF]  
This study defines the regions of Kir6.2 and SUR1 that contribute to one specific inhibitory interaction between these two proteins: namely, residues 28-32 of Kir6.2 and 196-288 of SUR1.

Umer Saleem, Mahyar Khaleghi, Nils G. Morgenthaler, Andreas Bergmann, Joachim Struck, Thomas H. Mosley, Jr., and Iftikhar J. Kullo

Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome
J Clin Endocrinol Metab 2009 94: 2558-2564 , doi:10.1210/jc.2008-2278 [Abstract] [Full Text] [PDF]  
Plasma carboxy-terminal pro-vasopressin (copeptin) is associated with measures of insulin resistance and metabolic syndrome in hypertensive adults.

Ali Mohamadi, Marco Martari, Cindy D. Holladay, John A. Phillips, III, Primus E. Mullis, and Roberto Salvatori

Mutation Analysis of the Muscarinic Cholinergic Receptor Genes in Isolated Growth Hormone Deficiency Type IB
J Clin Endocrinol Metab 2009 94: 2565-2570 , doi:10.1210/jc.2009-0512 [Abstract] [Full Text] [PDF]  
Muscarinic acetylcholine receptor mutations are rare or absent in familial isolated growth hormone deficiency.

Manuela Vargiolu, Daniela Fusco, Ivana Kurelac, Dietmar Dirnberger, Ralf Baumeister, Isabella Morra, Antonio Melcarne, Roberto Rimondini, Giovanni Romeo, and Elena Bonora

The Tyrosine Kinase Receptor RET Interacts in Vivo with Aryl Hydrocarbon Receptor-Interacting Protein to Alter Survivin Availability
J Clin Endocrinol Metab 2009 94: 2571-2578 , doi:10.1210/jc.2008-1980 [Abstract] [Full Text] [PDF]  
The identification of the aryl hydrocarbon receptor interacting protein-RET complex represents a starting point to study key cellular processes involved in RET induced apoptosis.

Cedric Moro, Magdalena Pasarica, Karen Elkind-Hirsch, and Leanne M. Redman

Aerobic Exercise Training Improves Atrial Natriuretic Peptide and Catecholamine-Mediated Lipolysis in Obese Women with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 2579-2586 , doi:10.1210/jc.2009-0051 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The regulation of lipolysis by the main endocrine hormones is impaired in women with PCOS, and these lipolytic defects can be partly reversed by aerobic exercise training independent of changes in body fat mass and sex hormones.

Lindsay R. Burch, Kaixin Zhou, Louise A. Donnelly, Alex S. F. Doney, Jeffrey Brady, Catharine Goddard, Andrew D. Morris, Michael K. Hansen, and Colin N. A. Palmer

A Single Nucleotide Polymorphism on Exon-4 of the Gene Encoding PPAR Is Associated with Reduced Height in Adults and Children
J Clin Endocrinol Metab 2009 94: 2587-2593 , doi:10.1210/jc.2009-0392 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Variation in PPARD is associated with reduced height, and this supports a role for PPAR in the regulation of nutritional utilization during growth.

Xiaofei Du, Robert L. Rosenfield, and Kenan Qin

KLF15 Is a Transcriptional Regulator of the Human 17β-Hydroxysteroid Dehydrogenase Type 5 Gene. A Potential Link between Regulation of Testosterone Production and Fat Stores in Women
J Clin Endocrinol Metab 2009 94: 2594-2601 , doi:10.1210/jc.2009-0139 [Abstract] [Full Text] [PDF]  
KLF15, a recently discovered multifunctional transcription factor, is a potential novel link between the regulation of human female testosterone production and fat stores by insulin.

Aline Hébrant, Jacqueline Van Sande, Pierre P. Roger, Martine Patey, Marc Klein, Claire Bournaud, Frédérique Savagner, Jacques Leclère, Jacques E. Dumont, Wilma C. G. van Staveren, and Carine Maenhaut

Thyroid Gene Expression in Familial Nonautoimmune Hyperthyroidism Shows Common Characteristics with Hyperfunctioning Autonomous Adenomas
J Clin Endocrinol Metab 2009 94: 2602-2609 , doi:10.1210/jc.2008-2191 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Autonomous adenomas and familial non-autoimmune hyperthyroidism are variants of one disease: genetic hyperthyroidism.

Kelly A. Landers, Brett D. McKinnon, Huika Li, V. Nathan Subramaniam, Robin H. Mortimer, and Kerry Richard

Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin
J Clin Endocrinol Metab 2009 94: 2610-2616 , doi:10.1210/jc.2009-0048 [Abstract] [Full Text] [PDF]  
Human placental and choriocarcinoma cells secrete transthyretin (TTR) which can bind to T4, resulting in the endocytosis of the TTR-T4 complex.

Assel Biyasheva, Richard S. Legro, Andrea Dunaif, and Margrit Urbanek

Evidence for Association between Polycystic Ovary Syndrome (PCOS) and TCF7L2 and Glucose Intolerance in Women with PCOS and TCF7L2
J Clin Endocrinol Metab 2009 94: 2617-2625 , doi:10.1210/jc.2008-1664 [Abstract] [Full Text] [PDF]  
Two independent TCF7L2 loci are associated with glucose tolerance in women with PCOS and with PCOS, respectively.

Nicté Figueroa-Vega, Manuel Alfonso-Pérez, Carlos Cuesta-Mateos, Francisco Sánchez-Madrid, Ricardo Moreno-Otero, Roberto González-Amaro, and Mónica Marazuela

Tie-2 Is Overexpressed by Monocytes in Autoimmune Thyroid Disorders and Participates in Their Recruitment to the Thyroid Gland
J Clin Endocrinol Metab 2009 94: 2626-2633 , doi:10.1210/jc.2009-0220 [Abstract] [Full Text] [PDF]  
The angiopoitien/Tie2 system may participate through different mechanisms in the pathogenesis of autoimmune thyroid disease.

Mario Durán-Prado, Manuel D. Gahete, Antonio J. Martínez-Fuentes, Raúl M. Luque, Ana Quintero, Susan M. Webb, Pedro Benito-López, Alfonso Leal, Stefan Schulz, F. Gracia-Navarro, María M. Malagón, and Justo P. Castaño

Identification and Characterization of Two Novel Truncated but Functional Isoforms of the Somatostatin Receptor Subtype 5 Differentially Present in Pituitary Tumors
J Clin Endocrinol Metab 2009 94: 2634-2643 , doi:10.1210/jc.2008-2564 [Abstract] [Full Text] [PDF]  
The somatostatin receptor family includes two newly identified, truncated variants of sst5, exhibiting distinct tissue distribution, pituitary tumor expression, and response to somatostatin and cortistatin.

John J. Peluso, Xiufang Liu, Anna Gawkowska, and Erika Johnston-MacAnanny

Progesterone Activates a Progesterone Receptor Membrane Component 1-Dependent Mechanism That Promotes Human Granulosa/Luteal Cell Survival But Not Progesterone Secretion
J Clin Endocrinol Metab 2009 94: 2644-2649 , doi:10.1210/jc.2009-0147 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In human granulosa/luteal cells, PGRMC1 functions as a receptor through which P4 activates a signal cascade that prevents apoptosis but it does not mediate P4’s ability to acutely promote its own secretion.

Yung Ming Lin, Chia Ling Chung, and Yu Sheng Cheng

Posttranscriptional Regulation of CDC25A by BOLL Is a Conserved Fertility Mechanism Essential for Human Spermatogenesis
J Clin Endocrinol Metab 2009 94: 2650-2657 , doi:10.1210/jc.2009-0108 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Human CDC25A is subject to translational control by BOLL, and their aberrant expressions are associated with male infertility.

Klemens Raile, Eva Klopocki, Martin Holder, Theda Wessel, Angela Galler, Dorothee Deiss, Dominik Müller, Thomas Riebel, Denise Horn, Monika Maringa, Jürgen Weber, Reinhard Ullmann, and Annette Grüters

Expanded Clinical Spectrum in Hepatocyte Nuclear Factor 1B-Maturity-Onset Diabetes of the Young
J Clin Endocrinol Metab 2009 94: 2658-2664 , doi:10.1210/jc.2008-2189 [Abstract] [Full Text] [PDF] [Supplemental Data]  
HNF1B-Maturity-onset diabetes of youth (MODY) has a broad clinical spectrum and heterozygous contiguous gene deletions, including HNF1B and 18 other known genes.

Translational Highlights from Endocrinology:

Yu Chen, Sumita Sood, Vidya M. R. Krishnamurthy, Peter Rotwein, and Ralph Rabkin

Abstracts:Endotoxin-Induced Growth Hormone Resistance in Skeletal Muscle
J Clin Endocrinol Metab 2009 94: 2670 [Full Text] [PDF]  

Don Sharkey, Michael E. Symonds, and Helen Budge

Abstracts:Adipose Tissue Inflammation: Developmental Ontogeny and Consequences of Gestational Nutrient Restriction in Offspring
J Clin Endocrinol Metab 2009 94: 2670-a [Full Text] [PDF]  

Danni Shi, Michael K. Dyck, Richard R. E. Uwiera, Jim C. Russell, Spencer D. Proctor, and Donna F. Vine

Abstracts:A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 2671 [Full Text] [PDF]  

Helen E. Scharfman, Gauri H. Malthankar-Phatak, Daniel Friedman, Patrice Pearce, Daniel P. McCloskey, Cynthia L. Harden, and Neil J. MacLusky

Abstracts:A Rat Model of Epilepsy in Women: A Tool to Study Physiological Interactions Between Endocrine Systems and Seizures
J Clin Endocrinol Metab 2009 94: 2671-a [Full Text] [PDF]  

ARTICLES:

Chong Xu, Jinhan He, Hongfeng Jiang, Luxia Zu, Wenjie Zhai, Shenshen Pu, and Guoheng Xu

Direct Effect of Glucocorticoids on Lipolysis in Adipocytes
J Clin Endocrinol Metab 2009 94: 2672 [Full Text] [PDF]  

Géraldine Parnaud, Eva Hammar, Pascale Ribaux, Marc Y. Donath, Thierry Berney, and Philippe A. Halban

Signaling Pathways Implicated in the Stimulation of β-Cell Proliferation by Extracellular Matrix
J Clin Endocrinol Metab 2009 94: 2672-a [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Linda L. Grasfeder, Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-yi Chang, and Donald P. McDonnell

Abstracts:Fasting-Induced Hepatic Production of DHEA Is Regulated by PGC-1, ERR and HNF4
J Clin Endocrinol Metab 2009 94: 2673 [Full Text] [PDF]  

Sakhila K. Banu, JeHoon Lee, V. O. Speights, Jr., Anna Starzinski-Powitz, and Joe A. Arosh

Abstracts:Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms
J Clin Endocrinol Metab 2009 94: 2673-a [Full Text] [PDF]  

Announcements and Resources:

Erratum
J Clin Endocrinol Metab 2009 94: 2674 [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2009 94: 2674-a [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2009 94: 2674-b [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2009 94: 2674-c [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Benjamin Leder, Shonni J. Silverberg, and Andrew F. Stewart

Patient Information Page from The Hormone Foundation:Exceso de calcio en la sangre (Hipercalcemia)
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Benjamin Leder, Shonni J. Silverberg, and Andrew F. Stewart

Patient Information Page from The Hormone Foundation:High Blood Calcium (Hypercalcemia)
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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